Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1734276..1734931 Replicon chromosome
Accession NZ_CP013341
Organism Nitrosomonas ureae strain Nm10

Toxin (Protein)


Gene name vapC Uniprot ID A0A1H2GQF6
Locus tag ATY38_RS07820 Protein ID WP_062558812.1
Coordinates 1734512..1734931 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1H2GPX7
Locus tag ATY38_RS07815 Protein ID WP_062558811.1
Coordinates 1734276..1734515 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ATY38_RS16060 1732181..1732327 - 147 WP_158441765.1 transposase -
ATY38_RS16065 1732333..1732617 + 285 WP_062558809.1 hypothetical protein -
ATY38_RS07805 1732795..1733637 + 843 WP_201011882.1 DDE-type integrase/transposase/recombinase -
ATY38_RS07810 1733708..1734061 + 354 WP_062558810.1 DsrE family protein -
ATY38_RS07815 1734276..1734515 + 240 WP_062558811.1 Arc family DNA-binding protein Antitoxin
ATY38_RS07820 1734512..1734931 + 420 WP_062558812.1 type II toxin-antitoxin system VapC family toxin Toxin
ATY38_RS07825 1735726..1736769 + 1044 WP_062558813.1 selenide, water dikinase SelD -
ATY38_RS07830 1736839..1737411 - 573 WP_062558814.1 adenylyltransferase/cytidyltransferase family protein -
ATY38_RS07835 1737384..1738034 - 651 WP_143023503.1 hypothetical protein -
ATY38_RS07840 1738147..1739313 + 1167 WP_062558265.1 IS4 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1662751..1735181 72430
- flank IS/Tn - - 1738180..1739313 1133


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin

Arc-like DNA binding domain

(9-42)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14912.21 Da        Isoelectric Point: 4.8483

>T58478 WP_062558812.1 NZ_CP013341:1734512-1734931 [Nitrosomonas ureae]
MIILDTNVISEPMKPNGNPAVQAWLDRQTAETLYLTATSLSELLVGIEILPEGKRKEGLDAALSKLMERLFGSRIVSFDQ
QAAIAYAPIVGRARTNGRLISVADGQIAAIAVVHGFTVATRDTAPFIAAGVPVINPWEE

Download         Length: 420 bp

>T58478 NZ_CP013341:1734512-1734931 [Nitrosomonas ureae]
ATGATTATTCTGGATACGAATGTCATATCCGAGCCGATGAAACCCAATGGCAATCCCGCCGTTCAGGCTTGGCTTGATCG
GCAGACGGCCGAGACACTTTATCTGACAGCAACAAGCCTTTCCGAATTGCTGGTCGGTATTGAGATCTTACCAGAAGGCA
AGCGTAAAGAAGGACTTGATGCCGCGTTGAGTAAGCTGATGGAGAGGCTTTTTGGGTCGCGCATAGTATCATTCGATCAA
CAGGCTGCAATAGCATATGCGCCCATAGTCGGTCGAGCTAGGACTAACGGTCGCCTCATCTCTGTGGCAGACGGTCAGAT
TGCTGCAATCGCGGTCGTACATGGATTCACCGTAGCGACTCGAGATACTGCGCCTTTTATCGCTGCCGGAGTGCCCGTCA
TCAATCCTTGGGAAGAATGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8842.91 Da        Isoelectric Point: 6.7262

>AT58478 WP_062558811.1 NZ_CP013341:1734276-1734515 [Nitrosomonas ureae]
MSVVTVRNLPEETHRALKLRAAQHGRSTEAEIREILEEAVRPRTRVKIGSELAAFGQSFGGLDFNHTRDQTPTDPAVFE

Download         Length: 240 bp

>AT58478 NZ_CP013341:1734276-1734515 [Nitrosomonas ureae]
ATGTCTGTTGTTACTGTTCGCAATTTGCCTGAAGAAACGCATCGCGCGCTTAAGCTGCGTGCTGCTCAGCATGGACGTAG
CACCGAAGCTGAAATCCGGGAAATTCTGGAAGAGGCAGTGCGTCCTAGGACGCGTGTCAAAATTGGATCAGAACTCGCTG
CTTTTGGGCAATCCTTTGGAGGGCTTGATTTTAATCACACTCGTGATCAGACGCCGACTGATCCGGCAGTGTTTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H2GQF6

Antitoxin

Source ID Structure
AlphaFold DB A0A1H2GPX7

References