Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4173901..4174520 Replicon chromosome
Accession NZ_CP013338
Organism Raoultella ornithinolytica strain Yangling I2

Toxin (Protein)


Gene name Hha Uniprot ID A0A514EV16
Locus tag ATN83_RS19410 Protein ID WP_004858783.1
Coordinates 4174302..4174520 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A514EV88
Locus tag ATN83_RS19405 Protein ID WP_004858785.1
Coordinates 4173901..4174275 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ATN83_RS19395 4169012..4170205 + 1194 WP_004858789.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
ATN83_RS19400 4170228..4173374 + 3147 WP_004858787.1 multidrug efflux RND transporter permease subunit -
ATN83_RS19405 4173901..4174275 + 375 WP_004858785.1 Hha toxicity modulator TomB Antitoxin
ATN83_RS19410 4174302..4174520 + 219 WP_004858783.1 hemolysin expression modulator Hha Toxin
ATN83_RS19415 4174672..4175238 + 567 WP_004858781.1 maltose O-acetyltransferase -
ATN83_RS19420 4175338..4175808 + 471 WP_004858780.1 YlaC family protein -
ATN83_RS19425 4175783..4177234 - 1452 WP_064357430.1 PLP-dependent aminotransferase family protein -
ATN83_RS19430 4177338..4178048 + 711 WP_004858778.1 GNAT family N-acetyltransferase -
ATN83_RS19435 4178045..4178185 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
ATN83_RS19440 4178188..4178448 - 261 WP_004858777.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8570.90 Da        Isoelectric Point: 7.9907

>T58473 WP_004858783.1 NZ_CP013338:4174302-4174520 [Raoultella ornithinolytica]
MSGEPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T58473 NZ_CP013338:4174302-4174520 [Raoultella ornithinolytica]
ATGTCTGGTGAACCATTAACCAAAACAGACTATTTGATGCGCTTACGTCGCTGTCAGACAATTGATACGCTGGAACGCGT
AATTGAAAAAAACAAATATGAACTTTCAGATAACGAACTGGCTGTATTTTACTCAGCGGCCGACCACCGTCTTGCTGAAT
TGACCATGAATAAGCTCTACGACAAAATCCCGACATCGGTGTGGAAGTTCATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14411.19 Da        Isoelectric Point: 4.8989

>AT58473 WP_004858785.1 NZ_CP013338:4173901-4174275 [Raoultella ornithinolytica]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYAEDNKLIAQLDEYL
DDTFMLFSSYGINTADLQKWRKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT58473 NZ_CP013338:4173901-4174275 [Raoultella ornithinolytica]
ATGGACGAATACTCGCCAAAAAGACATGATATCGCGCAGCTTCGATTTCTTTGCGAAACCCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGTAACCACGGGTGGGTGAATGATCCAACGTCGGCTATCAATCTTCAACTTAATGAATTGATCGAAC
ACATAGCCACGTTCGCGCTTAATTATAAAATTAAGTATGCTGAGGATAATAAACTGATCGCTCAGCTGGACGAATACCTG
GATGACACTTTTATGTTGTTCAGCAGTTATGGCATTAACACGGCCGATCTACAGAAATGGCGCAAATCGGGAAATCGGTT
ATTCCGATGTTTTGTCAACGCCAGTCGGGAAAATCCGGCAAGTCTTTCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A514EV16

Antitoxin

Source ID Structure
AlphaFold DB A0A514EV88

References