Detailed information of TA system TA058459

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-yefM/YoeB-RelB
• Location: 812051..812565
• Replicon: chromosome
• Accession: NZ_CP013336
• Organism: Fusobacterium hwasookii ChDC F206

Toxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: RN92_RS03960
• Protein ID: WP_029494261.1
• Coordinates: 812308..812565 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: U7TQU0
• Locus tag: RN92_RS03955
• Protein ID: WP_005919458.1
• Coordinates: 812051..812308 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RN92_RS03935	807185..809278	+	2094	WP_029490887.1	outer membrane protein assembly factor	-
RN92_RS03940	809318..809791	+	474	WP_029490886.1	OmpH family outer membrane protein	-
RN92_RS03945	809816..810814	+	999	WP_029495244.1	UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase	-
RN92_RS03950	810858..811931	+	1074	WP_029493185.1	glycerophosphodiester phosphodiesterase	-
RN92_RS03955	812051..812308	+	258	WP_005919458.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
RN92_RS03960	812308..812565	+	258	WP_029494261.1	Txe/YoeB family addiction module toxin	Toxin
RN92_RS03965	812682..813758	+	1077	WP_029490883.1	DHH family phosphoesterase	-
RN92_RS03970	813991..814728	+	738	WP_029494262.1	tRNA pseudouridine(38-40) synthase TruA	-
RN92_RS03975	814936..815511	+	576	WP_029490878.1	aminoacyl-tRNA hydrolase	-
RN92_RS03980	815586..816893	+	1308	WP_029495243.1	electron transport complex subunit RsxC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 10060.57 Da
• Isoelectric Point: 9.7287

>T58459 WP_029494261.1 NZ_CP013336:812308-812565 [Fusobacterium hwasookii ChDC F206]
MLLTWTDFASKQYEELQEKDKRLIKKINILIKDIKRNGNEGIGKPEPLQHELSGYWSRRIDDKNRLVYKVSDNQITIVAC
ANHYK

Nucleotide

• Length: 258 bp

>T58459 NZ_CP013336:812308-812565 [Fusobacterium hwasookii ChDC F206]
ATGTTATTAACTTGGACCGATTTTGCATCGAAACAATATGAAGAGCTACAAGAGAAGGATAAAAGGCTTATAAAGAAGAT
AAATATACTTATTAAGGATATAAAAAGAAATGGAAATGAAGGAATAGGTAAACCAGAGCCTTTACAACATGAGTTAAGTG
GCTATTGGAGTAGAAGAATTGATGATAAAAATAGATTAGTCTATAAAGTATCAGATAATCAAATAACAATAGTTGCTTGT
GCAAATCATTATAAGTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10110.43 Da
• Isoelectric Point: 4.7022

>AT58459 WP_005919458.1 NZ_CP013336:812051-812308 [Fusobacterium hwasookii ChDC F206]
MIATNYSEVRNNLKAYCDKATKDYETIIITRKNNENVVLMSEEEYNNLMENLYIRSNLKYYQKLVESIKEVEKGNVKEHD
LIEVD

Nucleotide

• Length: 258 bp

>AT58459 NZ_CP013336:812051-812308 [Fusobacterium hwasookii ChDC F206]
ATGATAGCAACTAATTATTCTGAAGTTAGAAATAATTTAAAAGCTTATTGTGATAAGGCAACTAAGGACTATGAAACTAT
TATTATTACAAGAAAAAATAATGAAAATGTTGTCTTAATGAGTGAAGAAGAATATAATAATCTTATGGAAAACCTTTATA
TAAGATCAAATCTTAAATATTATCAAAAACTTGTAGAAAGTATAAAAGAAGTTGAAAAAGGTAATGTTAAAGAACATGAT
TTAATAGAGGTGGATTAA

Structures

Antitoxin

• AlphaFold DB: A0A0S2ZLE4