Detailed information of TA system TA058456

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higB-toxA/Tad-HTH_37
• Location: 2381395..2382040
• Replicon: chromosome
• Accession: NZ_CP013331
• Organism: Fusobacterium hwasookii ChDC F174

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A0S2ZQ59
• Locus tag: RN87_RS11140
• Protein ID: WP_029492812.1
• Coordinates: 2381672..2382040 (-)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: toxA
• Uniprot ID: -
• Locus tag: RN87_RS11135
• Protein ID: WP_029492811.1
• Coordinates: 2381395..2381682 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RN87_RS11095	2376615..2377268	-	654	WP_029490940.1	Crp/Fnr family transcriptional regulator	-
RN87_RS11100	2377452..2378204	+	753	WP_029492804.1	SDR family oxidoreductase	-
RN87_RS11105	2378324..2379076	+	753	WP_029492805.1	MgtC/SapB family protein	-
RN87_RS11110	2379076..2379648	+	573	WP_029492806.1	crossover junction endodeoxyribonuclease RuvC	-
RN87_RS11115	2379658..2380164	+	507	WP_029492807.1	HAD family hydrolase	-
RN87_RS11120	2380187..2380729	+	543	WP_029492808.1	hypothetical protein	-
RN87_RS11125	2380769..2380987	-	219	WP_029492809.1	CopG family transcriptional regulator	-
RN87_RS11130	2381052..2381372	-	321	WP_029492810.1	nucleotidyltransferase domain-containing protein	-
RN87_RS11135	2381395..2381682	-	288	WP_029492811.1	helix-turn-helix domain-containing protein	Antitoxin
RN87_RS11140	2381672..2382040	-	369	WP_029492812.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
RN87_RS11145	2382155..2382964	-	810	WP_060568858.1	hypothetical protein	-
RN87_RS11150	2383060..2385348	-	2289	WP_029492814.1	SUMF1/EgtB/PvdO family nonheme iron enzyme	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (35-110)

Antitoxin

• Cro/C1-type helix-turn-helix domain (39-89)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 14808.40 Da
• Isoelectric Point: 10.4437

>T58456 WP_029492812.1 NZ_CP013331:c2382040-2381672 [Fusobacterium hwasookii ChDC F174]
MYKVGFYLKNGKSDIIEYLDKLKIKSEKSKEARIIRNKILSYIKSLELYGTRVGEPIVKHIEDNIWELRPLNNRIFFFYF
KDNKFILLHYFIKKTNKTPKKEIEEARNRMNDFIVRSDKNVK

Nucleotide

• Length: 369 bp

>T58456 NZ_CP013331:c2382040-2381672 [Fusobacterium hwasookii ChDC F174]
ATGTACAAAGTTGGGTTTTATTTAAAAAATGGAAAATCTGATATAATAGAATATTTAGACAAATTAAAAATAAAATCTGA
AAAAAGTAAAGAGGCAAGAATAATAAGAAATAAAATATTAAGTTATATCAAGTCATTAGAGCTATATGGAACAAGAGTTG
GAGAACCTATTGTAAAACATATTGAAGATAATATTTGGGAACTAAGACCATTAAACAATAGAATATTTTTCTTTTATTTT
AAAGATAATAAATTTATTTTACTACATTATTTTATAAAAAAGACTAATAAAACACCTAAAAAAGAAATAGAAGAAGCTAG
AAATAGAATGAATGATTTTATAGTAAGGAGTGATAAGAATGTCAAATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10950.79 Da
• Isoelectric Point: 5.1767

>AT58456 WP_029492811.1 NZ_CP013331:c2381682-2381395 [Fusobacterium hwasookii ChDC F174]
MSNNEYLDFDDYFNDETKVSKEDKAIIELETLLIGKMIEIREKKGLTQRQLAELTGMKQPAIARLEKLQTIPHLTTLIKF
LTPLGYKLSIVPIEN

Nucleotide

• Length: 288 bp

>AT58456 NZ_CP013331:c2381682-2381395 [Fusobacterium hwasookii ChDC F174]
ATGTCAAATAATGAATATTTAGATTTTGATGATTATTTTAATGATGAAACAAAAGTAAGTAAAGAGGATAAGGCAATAAT
AGAATTAGAAACCTTATTGATTGGTAAAATGATAGAAATTAGAGAGAAAAAAGGTTTAACCCAAAGGCAACTTGCTGAAT
TAACAGGTATGAAACAACCTGCCATAGCAAGACTTGAAAAGTTACAAACAATTCCTCATCTAACAACTTTAATAAAATTT
TTAACACCATTAGGTTATAAATTATCAATAGTTCCTATTGAAAATTAA

Structures

Toxin

• AlphaFold DB: A0A0S2ZQ59