Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-RelB
Location 799079..799593 Replicon chromosome
Accession NZ_CP013331
Organism Fusobacterium hwasookii ChDC F174

Toxin (Protein)


Gene name relB Uniprot ID X7SD51
Locus tag RN87_RS03715 Protein ID WP_005919455.1
Coordinates 799336..799593 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID U7TQU0
Locus tag RN87_RS03710 Protein ID WP_005919458.1
Coordinates 799079..799336 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RN87_RS03690 794213..796306 + 2094 WP_029493187.1 outer membrane protein assembly factor -
RN87_RS03695 796346..796819 + 474 WP_029490886.1 OmpH family outer membrane protein -
RN87_RS03700 796844..797842 + 999 WP_029493186.1 UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase -
RN87_RS03705 797886..798959 + 1074 WP_029493185.1 glycerophosphodiester phosphodiesterase -
RN87_RS03710 799079..799336 + 258 WP_005919458.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
RN87_RS03715 799336..799593 + 258 WP_005919455.1 Txe/YoeB family addiction module toxin Toxin
RN87_RS03720 799710..800786 + 1077 WP_029493184.1 DHH family phosphoesterase -
RN87_RS03725 801016..801753 + 738 WP_029493183.1 tRNA pseudouridine(38-40) synthase TruA -
RN87_RS03730 801875..802732 + 858 WP_029493182.1 toxin-antitoxin system YwqK family antitoxin -
RN87_RS03735 802999..803631 + 633 WP_029493181.1 DUF1871 family protein -
RN87_RS03740 803857..804093 + 237 WP_029493180.1 hypothetical protein -
RN87_RS03745 804139..804408 + 270 WP_029493179.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10159.71 Da        Isoelectric Point: 9.7287

>T58455 WP_005919455.1 NZ_CP013331:799336-799593 [Fusobacterium hwasookii ChDC F174]
MLLTWTDFAWKQYEELQEKDKRLIKKINILIKDIKRNGNEGIGKPEPLQHELSGYWSRRIDDKNRLVYKVSDNQITIVAC
ANHYK

Download         Length: 258 bp

>T58455 NZ_CP013331:799336-799593 [Fusobacterium hwasookii ChDC F174]
ATGTTATTAACTTGGACCGATTTTGCATGGAAACAATATGAAGAGCTACAAGAGAAGGATAAAAGGCTTATAAAGAAGAT
AAATATACTTATTAAGGATATAAAAAGAAATGGAAATGAAGGAATAGGTAAACCAGAGCCTTTACAACATGAGTTAAGTG
GCTATTGGAGTAGAAGAATTGATGATAAAAATAGATTAGTCTATAAAGTATCAGATAATCAAATAACAATAGTTGCTTGT
GCAAATCATTATAAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10110.43 Da        Isoelectric Point: 4.7022

>AT58455 WP_005919458.1 NZ_CP013331:799079-799336 [Fusobacterium hwasookii ChDC F174]
MIATNYSEVRNNLKAYCDKATKDYETIIITRKNNENVVLMSEEEYNNLMENLYIRSNLKYYQKLVESIKEVEKGNVKEHD
LIEVD

Download         Length: 258 bp

>AT58455 NZ_CP013331:799079-799336 [Fusobacterium hwasookii ChDC F174]
ATGATAGCAACTAATTATTCTGAAGTTAGAAATAATTTAAAAGCTTATTGTGATAAGGCAACTAAGGACTATGAAACTAT
TATTATTACAAGAAAAAATAATGAAAATGTTGTCTTAATGAGTGAAGAAGAATATAATAATCTTATGGAAAACCTTTATA
TAAGATCAAATCTTAAATATTATCAAAAACTTGTAGAAAGTATAAAAGAAGTTGAAAAAGGTAATGTTAAAGAACATGAT
TTAATAGAGGTGGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0S2ZLL4

Antitoxin

Source ID Structure
AlphaFold DB A0A0S2ZLE4

References