Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1675086..1675602 Replicon chromosome
Accession NZ_CP013322
Organism Klebsiella pneumoniae strain CAV1193

Toxin (Protein)


Gene name relE Uniprot ID A0A085DK79
Locus tag AGG09_RS08310 Protein ID WP_009309309.1
Coordinates 1675086..1675370 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag AGG09_RS08315 Protein ID WP_002886901.1
Coordinates 1675360..1675602 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AGG09_RS08280 1670570..1670878 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
AGG09_RS33110 1670963..1671136 + 174 WP_047718306.1 hypothetical protein -
AGG09_RS08290 1671139..1671882 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
AGG09_RS08300 1672239..1674377 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
AGG09_RS08305 1674618..1675082 + 465 WP_047718307.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
AGG09_RS08310 1675086..1675370 - 285 WP_009309309.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AGG09_RS08315 1675360..1675602 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
AGG09_RS08320 1675680..1677590 - 1911 WP_004152270.1 BglG family transcription antiterminator -
AGG09_RS08325 1677613..1678767 - 1155 WP_047718309.1 lactonase family protein -
AGG09_RS08330 1678834..1679574 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11141.99 Da        Isoelectric Point: 10.3787

>T58435 WP_009309309.1 NZ_CP013322:c1675370-1675086 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T58435 NZ_CP013322:c1675370-1675086 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCTGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT58435 WP_002886901.1 NZ_CP013322:c1675602-1675360 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT58435 NZ_CP013322:c1675602-1675360 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGTCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A085DK79

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References