Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RelE-RelB |
| Location | 382398..382957 | Replicon | chromosome |
| Accession | NZ_CP013320 | ||
| Organism | Vibrio cholerae strain NCTC9420 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | Q9K2M8 |
| Locus tag | ASZ86_RS16295 | Protein ID | WP_000578476.1 |
| Coordinates | 382398..382676 (-) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | Q9L991 |
| Locus tag | ASZ86_RS16300 | Protein ID | WP_000381183.1 |
| Coordinates | 382673..382957 (-) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ASZ86_RS16250 | 377476..377982 | + | 507 | WP_000393074.1 | hypothetical protein | - |
| ASZ86_RS16255 | 378139..378525 | + | 387 | WP_000703163.1 | VOC family protein | - |
| ASZ86_RS16260 | 378782..378985 | + | 204 | WP_001911580.1 | hypothetical protein | - |
| ASZ86_RS16265 | 379180..379431 | + | 252 | Protein_381 | TIGR03643 family protein | - |
| ASZ86_RS16270 | 379404..379553 | + | 150 | WP_071908333.1 | DUF3265 domain-containing protein | - |
| ASZ86_RS16275 | 379700..380125 | + | 426 | WP_000415750.1 | hypothetical protein | - |
| ASZ86_RS16280 | 380331..380954 | + | 624 | WP_000247070.1 | DUF1349 domain-containing protein | - |
| ASZ86_RS16285 | 381167..381646 | + | 480 | WP_000009888.1 | lecithin retinol acyltransferase family protein | - |
| ASZ86_RS16290 | 381834..382247 | + | 414 | WP_000049420.1 | VOC family protein | - |
| ASZ86_RS16295 | 382398..382676 | - | 279 | WP_000578476.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | Toxin |
| ASZ86_RS16300 | 382673..382957 | - | 285 | WP_000381183.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| ASZ86_RS16310 | 383152..383667 | + | 516 | WP_001201520.1 | lipocalin family protein | - |
| ASZ86_RS16315 | 383732..384328 | + | 597 | WP_000255434.1 | hypothetical protein | - |
| ASZ86_RS16330 | 384720..384902 | + | 183 | WP_000923182.1 | DUF645 family protein | - |
| ASZ86_RS16335 | 385102..385575 | + | 474 | WP_001161076.1 | GrpB family protein | - |
| ASZ86_RS16340 | 385590..385682 | + | 93 | WP_014378730.1 | DUF3265 domain-containing protein | - |
| ASZ86_RS16345 | 385724..386350 | + | 627 | WP_000365424.1 | LysE family translocator | - |
| ASZ86_RS16350 | 386473..387171 | + | 699 | WP_001890502.1 | hypothetical protein | - |
| ASZ86_RS16355 | 387181..387291 | + | 111 | WP_079857360.1 | DUF3265 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 304702..436238 | 131536 | |
| - | inside | Integron | - | - | 309782..435862 | 126080 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10819.59 Da Isoelectric Point: 5.1651
>T58421 WP_000578476.1 NZ_CP013320:c382676-382398 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND
Download Length: 279 bp
>T58421 NZ_CP013320:c382676-382398 [Vibrio cholerae]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA
Antitoxin
Download Length: 95 a.a. Molecular weight: 10901.25 Da Isoelectric Point: 8.0775
>AT58421 WP_000381183.1 NZ_CP013320:c382957-382673 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA
Download Length: 285 bp
>AT58421 NZ_CP013320:c382957-382673 [Vibrio cholerae]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | Q9K2M8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A067BL33 |