58417

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 351438..351978 Replicon chromosome
Accession NZ_CP013320
Organism Vibrio cholerae strain NCTC9420

Toxin (Protein)


Gene name relE Uniprot ID A0A151JGK8
Locus tag ASZ86_RS15960 Protein ID WP_000277238.1
Coordinates 351438..351707 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KML3
Locus tag ASZ86_RS15965 Protein ID WP_001258569.1
Coordinates 351700..351978 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASZ86_RS15905 346442..346684 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
ASZ86_RS15910 346928..347314 + 387 WP_071919817.1 NUDIX hydrolase -
ASZ86_RS15915 347371..347484 + 114 WP_001900214.1 hypothetical protein -
ASZ86_RS15920 347433..347714 + 282 WP_001894429.1 DUF1289 domain-containing protein -
ASZ86_RS15930 347972..348508 + 537 WP_000469482.1 GNAT family N-acetyltransferase -
ASZ86_RS15935 348645..349160 + 516 WP_001201509.1 lipocalin family protein -
ASZ86_RS15940 349310..349807 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
ASZ86_RS15945 349804..350076 - 273 WP_000246253.1 DUF1778 domain-containing protein -
ASZ86_RS15950 350469..350594 + 126 WP_001900195.1 DUF645 family protein -
ASZ86_RS20390 350610..350648 + 39 WP_106019118.1 hypothetical protein -
ASZ86_RS15955 350844..351290 + 447 WP_000006157.1 hypothetical protein -
ASZ86_RS15960 351438..351707 - 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin Toxin
ASZ86_RS15965 351700..351978 - 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
ASZ86_RS15970 352228..352485 + 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
ASZ86_RS15975 352473..352775 + 303 WP_000229318.1 type II toxin-antitoxin system RelE/ParE family toxin -
ASZ86_RS15980 353064..353288 + 225 WP_001894423.1 DUF3709 domain-containing protein -
ASZ86_RS15985 353732..353851 + 120 WP_071919600.1 DUF645 family protein -
ASZ86_RS20405 353855..353908 + 54 Protein_332 DUF645 family protein -
ASZ86_RS16000 354510..355514 + 1005 WP_000964931.1 LD-carboxypeptidase -
ASZ86_RS16010 356289..356469 + 181 Protein_334 DUF645 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 304702..436238 131536
- inside Integron - - 309782..435862 126080


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10406.11 Da        Isoelectric Point: 9.5084

>T58417 WP_000277238.1 NZ_CP013320:c351707-351438 [Vibrio cholerae]
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF

Download         Length: 270 bp

>T58417 NZ_CP013320:c351707-351438 [Vibrio cholerae]
ATGTATAAACTCGAATACTCCACACAGTTTAAGAAAGATTTCAAAAAGATAACTAAGATGCCGATTTCAGACATCATTGA
AGTCGGCAATGTTATTTCTAAGCTGCAACGCGGCGAAAAGCTTGAACCCAAGAATGTTGACCATCCGTTAACTGGAAATT
GGGTTGGATTTCGAGACTGCCACATTAAACCCGACCTAGTGTTAATCTATCGAGTTTTTAACGATCAACTACAACTAGCG
CGCATTGGTTCACATAGTGATTTATTCTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10088.58 Da        Isoelectric Point: 6.0728

>AT58417 WP_001258569.1 NZ_CP013320:c351978-351700 [Vibrio cholerae]
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV

Download         Length: 279 bp

>AT58417 NZ_CP013320:c351978-351700 [Vibrio cholerae]
ATGAGAACAGAAATGCTGAGCACGCGCATTGACCACGACACGAAAATTGCGTTCACAAACGTCTGCGATGAGATGGGTCT
AAGTACATCACAGGCCATAAAGTTATTTGCAAAAGCGGTTATTAATCATGGTGGAATCCCTTTTGAGCTGCGAGTTCCAC
AGCCTAATGAGGTTACTGCATCTGCAATTCAAGAGCTCGTTGAAGGAAAAGGACATAAAGCTGAATCCGTTGAAGCTATG
CTGAATGAGCTTACTGAAGGCAAAGTTAAGCATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A151JGK8

Antitoxin

Source ID Structure
AlphaFold DB A0A151KTP9

References