58416

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 349310..350076 Replicon chromosome
Accession NZ_CP013320
Organism Vibrio cholerae strain NCTC9420

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag ASZ86_RS15940 Protein ID WP_000982260.1
Coordinates 349310..349807 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag ASZ86_RS15945 Protein ID WP_000246253.1
Coordinates 349804..350076 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASZ86_RS15890 344752..345456 + 705 WP_000087610.1 HNH endonuclease -
ASZ86_RS15895 345614..345952 + 339 WP_000713853.1 hypothetical protein -
ASZ86_RS15900 346106..346423 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin -
ASZ86_RS15905 346442..346684 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
ASZ86_RS15910 346928..347314 + 387 WP_071919817.1 NUDIX hydrolase -
ASZ86_RS15915 347371..347484 + 114 WP_001900214.1 hypothetical protein -
ASZ86_RS15920 347433..347714 + 282 WP_001894429.1 DUF1289 domain-containing protein -
ASZ86_RS15930 347972..348508 + 537 WP_000469482.1 GNAT family N-acetyltransferase -
ASZ86_RS15935 348645..349160 + 516 WP_001201509.1 lipocalin family protein -
ASZ86_RS15940 349310..349807 - 498 WP_000982260.1 GNAT family N-acetyltransferase Toxin
ASZ86_RS15945 349804..350076 - 273 WP_000246253.1 DUF1778 domain-containing protein Antitoxin
ASZ86_RS15950 350469..350594 + 126 WP_001900195.1 DUF645 family protein -
ASZ86_RS20390 350610..350648 + 39 WP_106019118.1 hypothetical protein -
ASZ86_RS15955 350844..351290 + 447 WP_000006157.1 hypothetical protein -
ASZ86_RS15960 351438..351707 - 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin -
ASZ86_RS15965 351700..351978 - 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
ASZ86_RS15970 352228..352485 + 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
ASZ86_RS15975 352473..352775 + 303 WP_000229318.1 type II toxin-antitoxin system RelE/ParE family toxin -
ASZ86_RS15980 353064..353288 + 225 WP_001894423.1 DUF3709 domain-containing protein -
ASZ86_RS15985 353732..353851 + 120 WP_071919600.1 DUF645 family protein -
ASZ86_RS20405 353855..353908 + 54 Protein_332 DUF645 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 304702..436238 131536
- inside Integron - - 309782..435862 126080


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T58416 WP_000982260.1 NZ_CP013320:c349807-349310 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T58416 NZ_CP013320:c349807-349310 [Vibrio cholerae]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT58416 WP_000246253.1 NZ_CP013320:c350076-349804 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT58416 NZ_CP013320:c350076-349804 [Vibrio cholerae]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0KGB1

Antitoxin

Source ID Structure
AlphaFold DB A0A0F2IC79

References