Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-Phd |
| Location | 346106..346684 | Replicon | chromosome |
| Accession | NZ_CP013320 | ||
| Organism | Vibrio cholerae strain NCTC9420 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | O68848 |
| Locus tag | ASZ86_RS15900 | Protein ID | WP_001180243.1 |
| Coordinates | 346106..346423 (-) | Length | 106 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | Q7DCR7 |
| Locus tag | ASZ86_RS15905 | Protein ID | WP_000557292.1 |
| Coordinates | 346442..346684 (-) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ASZ86_RS15870 | 341630..341812 | + | 183 | WP_000923340.1 | DUF645 family protein | - |
| ASZ86_RS15875 | 342166..342348 | + | 183 | WP_000923153.1 | DUF645 family protein | - |
| ASZ86_RS15880 | 342543..343220 | + | 678 | WP_000254617.1 | HNH endonuclease | - |
| ASZ86_RS15885 | 343382..344590 | + | 1209 | WP_001900186.1 | deoxyguanosinetriphosphate triphosphohydrolase family protein | - |
| ASZ86_RS15890 | 344752..345456 | + | 705 | WP_000087610.1 | HNH endonuclease | - |
| ASZ86_RS15895 | 345614..345952 | + | 339 | WP_000713853.1 | hypothetical protein | - |
| ASZ86_RS15900 | 346106..346423 | - | 318 | WP_001180243.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| ASZ86_RS15905 | 346442..346684 | - | 243 | WP_000557292.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| ASZ86_RS15910 | 346928..347314 | + | 387 | WP_071919817.1 | NUDIX hydrolase | - |
| ASZ86_RS15915 | 347371..347484 | + | 114 | WP_001900214.1 | hypothetical protein | - |
| ASZ86_RS15920 | 347433..347714 | + | 282 | WP_001894429.1 | DUF1289 domain-containing protein | - |
| ASZ86_RS15930 | 347972..348508 | + | 537 | WP_000469482.1 | GNAT family N-acetyltransferase | - |
| ASZ86_RS15935 | 348645..349160 | + | 516 | WP_001201509.1 | lipocalin family protein | - |
| ASZ86_RS15940 | 349310..349807 | - | 498 | WP_000982260.1 | GNAT family N-acetyltransferase | - |
| ASZ86_RS15945 | 349804..350076 | - | 273 | WP_000246253.1 | DUF1778 domain-containing protein | - |
| ASZ86_RS15950 | 350469..350594 | + | 126 | WP_001900195.1 | DUF645 family protein | - |
| ASZ86_RS20390 | 350610..350648 | + | 39 | WP_106019118.1 | hypothetical protein | - |
| ASZ86_RS15955 | 350844..351290 | + | 447 | WP_000006157.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 304702..436238 | 131536 | |
| - | inside | Integron | - | - | 309782..435862 | 126080 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 106 a.a. Molecular weight: 12158.97 Da Isoelectric Point: 9.7495
>T58415 WP_001180243.1 NZ_CP013320:c346423-346106 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS
Download Length: 318 bp
>T58415 NZ_CP013320:c346423-346106 [Vibrio cholerae]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG
Antitoxin
Download Length: 81 a.a. Molecular weight: 8961.25 Da Isoelectric Point: 5.6630
>AT58415 WP_000557292.1 NZ_CP013320:c346684-346442 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL
Download Length: 243 bp
>AT58415 NZ_CP013320:c346684-346442 [Vibrio cholerae]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0K9UJR8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | Q7DCR7 |