Detailed information of TA system TA058413

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): DhiAT/-
• Location: 327370..328154
• Replicon: chromosome
• Accession: NZ_CP013320
• Organism: Vibrio cholerae strain NCTC9420

Toxin (Protein)

• Gene name: dhiT
• Uniprot ID: A0A086SLD6
• Locus tag: ASZ86_RS15745
• Protein ID: WP_001114075.1
• Coordinates: 327370..327639 (+)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: dhiA
• Uniprot ID: -
• Locus tag: ASZ86_RS15750
• Protein ID: WP_071919816.1
• Coordinates: 327633..328154 (+)
• Length: 174 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ASZ86_RS15700	322669..323364	+	696	WP_001900183.1	hypothetical protein	-
ASZ86_RS15705	323484..323921	+	438	WP_173664326.1	hypothetical protein	-
ASZ86_RS15710	323899..324048	+	150	WP_001900216.1	DUF3265 domain-containing protein	-
ASZ86_RS20330	324667..324846	+	180	Protein_282	DUF645 family protein	-
ASZ86_RS15725	325064..325492	+	429	WP_000620002.1	N-acetyltransferase	-
ASZ86_RS15735	326080..326562	+	483	WP_000422940.1	GNAT family N-acetyltransferase	-
ASZ86_RS15745	327370..327639	+	270	WP_001114075.1	DUF4160 domain-containing protein	Toxin
ASZ86_RS15750	327633..328154	+	522	WP_071919816.1	DUF2442 domain-containing protein	Antitoxin
ASZ86_RS20065	328211..328324	+	114	WP_001894981.1	hypothetical protein	-
ASZ86_RS15760	328293..329129	+	837	WP_000242986.1	hypothetical protein	-
ASZ86_RS15765	329294..329932	+	639	WP_000230118.1	HD domain-containing protein	-
ASZ86_RS20345	330022..330182	+	161	Protein_290	DUF3709 domain-containing protein	-
ASZ86_RS15770	330203..330424	+	222	WP_012705854.1	DUF3709 domain-containing protein	-
ASZ86_RS15780	330744..331064	+	321	WP_001909340.1	DUF1778 domain-containing protein	-
ASZ86_RS15785	331061..331594	+	534	WP_000118351.1	GNAT family N-acetyltransferase	-
ASZ86_RS15790	331832..332110	+	279	WP_000280324.1	DUF3709 domain-containing protein	-
ASZ86_RS15795	332511..332735	+	225	WP_001894423.1	DUF3709 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	304702..436238	131536
	-	inside	Integron	-	-	309782..435862	126080

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF4160 (9-74)

Antitoxin

• Protein of unknown function DUF2442 (4-59)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10310.94 Da
• Isoelectric Point: 6.6303

>T58413 WP_001114075.1 NZ_CP013320:327370-327639 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Nucleotide

• Length: 270 bp

>T58413 NZ_CP013320:327370-327639 [Vibrio cholerae]
ATGCCAGAGATTGATGCCCTATTAGGCCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTGCCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAAC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA

Antitoxin

Protein

• Length: 174 a.a.
• Molecular weight: 19449.07 Da
• Isoelectric Point: 6.7342

>AT58413 WP_071919816.1 NZ_CP013320:327633-328154 [Vibrio cholerae]
MLKVIDVDFVSDHTLELTFNDGYQGYADLPVYFKKTPFSEIKDFKRFSLTRDGSLNWDGNELTAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQFGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI

Nucleotide

• Length: 522 bp

>AT58413 NZ_CP013320:327633-328154 [Vibrio cholerae]
ATGTTGAAAGTCATAGATGTTGATTTTGTCTCAGACCATACATTAGAACTGACGTTCAATGATGGTTACCAAGGCTATGC
CGACTTGCCGGTATACTTTAAAAAAACACCGTTTTCAGAAATTAAGGACTTTAAACGCTTTTCCTTGACTCGTGATGGCT
CGTTAAATTGGGATGGTAATGAGTTAACGGCCGCGACACTCCGTGACATAACCAAGGGCTCACAAAAGTCGGTGGAGTTA
AGTTTTAATGTTCAAGAAATGGAAGCCGTCATCAAACAGGCCTCATGGGAATCGATGATGGAGGGGCGTCCCGACATCTT
GCAAGCGGCTATTCGTTCTTACGTAGAGCAGTTTGGTCATGGTCAAGTTATTGCAAAGGCGGGTATAAAAAGTCGTACGA
GTGCTTATCGCTCCTTGAAGCCAGAAACAACGCCAAACTTTGGCACACTAGTTCAGTTAGGGCACGCCGTCATCGAACTA
GCGAAAGATAGAACAGTGGCAAACAAGGAACCACGCATATAA

Structures

Toxin

• AlphaFold DB: A0A086SLD6