58336

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 781776..782354 Replicon chromosome
Accession NZ_CP013312
Organism Vibrio cholerae strain E1320

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag ASZ88_RS17995 Protein ID WP_001180243.1
Coordinates 781776..782093 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag ASZ88_RS18000 Protein ID WP_000557292.1
Coordinates 782112..782354 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASZ88_RS21065 777034..777237 + 204 WP_001911745.1 hypothetical protein -
ASZ88_RS17945 777399..777674 + 276 WP_071919587.1 hypothetical protein -
ASZ88_RS20980 777682..777858 + 177 WP_001275592.1 hypothetical protein -
ASZ88_RS17950 778009..778371 + 363 WP_000454151.1 hypothetical protein -
ASZ88_RS20780 778371..778457 + 87 WP_071917830.1 DUF3265 domain-containing protein -
ASZ88_RS17960 778522..778797 + 276 WP_000382676.1 hypothetical protein -
ASZ88_RS17965 778870..779334 - 465 WP_000140243.1 hypothetical protein -
ASZ88_RS17970 779672..780355 + 684 WP_000582687.1 FRG domain-containing protein -
ASZ88_RS21070 780474..781136 + 663 WP_000084911.1 Vat family streptogramin A O-acetyltransferase -
ASZ88_RS21185 781487..781582 + 96 WP_001907607.1 DUF645 family protein -
ASZ88_RS17995 781776..782093 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ASZ88_RS18000 782112..782354 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ASZ88_RS18005 782596..783105 + 510 WP_000405987.1 GNAT family N-acetyltransferase -
ASZ88_RS18010 783402..783581 + 180 WP_001883039.1 DUF645 family protein -
ASZ88_RS18015 783777..784202 + 426 WP_000403014.1 GNAT family N-acetyltransferase -
ASZ88_RS18020 784351..784698 + 348 WP_000933409.1 hypothetical protein -
ASZ88_RS20800 784845..785138 + 294 WP_125460920.1 hypothetical protein -
ASZ88_RS18025 785312..785815 + 504 WP_001158944.1 DinB family protein -
ASZ88_RS20815 786121..786291 + 171 Protein_769 DUF645 family protein -
ASZ88_RS20825 786648..786827 + 180 Protein_770 DUF645 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 688711..843534 154823
- inside Integron catB9 - 693791..843158 149367


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T58336 WP_001180243.1 NZ_CP013312:c782093-781776 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T58336 NZ_CP013312:c782093-781776 [Vibrio cholerae]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT58336 WP_000557292.1 NZ_CP013312:c782354-782112 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT58336 NZ_CP013312:c782354-782112 [Vibrio cholerae]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UJR8

Antitoxin

Source ID Structure
AlphaFold DB Q7DCR7

References