Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/ParE-Phd |
Location | 734715..735262 | Replicon | chromosome |
Accession | NZ_CP013312 | ||
Organism | Vibrio cholerae strain E1320 |
Toxin (Protein)
Gene name | relE | Uniprot ID | C3LV30 |
Locus tag | ASZ88_RS17510 | Protein ID | WP_000229318.1 |
Coordinates | 734960..735262 (+) | Length | 101 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | Q9KM93 |
Locus tag | ASZ88_RS17505 | Protein ID | WP_000861987.1 |
Coordinates | 734715..734972 (+) | Length | 86 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
ASZ88_RS17450 | 729858..729971 | + | 114 | WP_001900214.1 | hypothetical protein | - |
ASZ88_RS17455 | 729920..730201 | + | 282 | WP_001894429.1 | DUF1289 domain-containing protein | - |
ASZ88_RS17465 | 730459..730995 | + | 537 | WP_000469482.1 | GNAT family N-acetyltransferase | - |
ASZ88_RS17470 | 731132..731647 | + | 516 | WP_001201509.1 | lipocalin family protein | - |
ASZ88_RS17475 | 731797..732294 | - | 498 | WP_000982260.1 | GNAT family N-acetyltransferase | - |
ASZ88_RS17480 | 732291..732563 | - | 273 | WP_000246253.1 | DUF1778 domain-containing protein | - |
ASZ88_RS20645 | 732956..733081 | + | 126 | WP_001900195.1 | DUF645 family protein | - |
ASZ88_RS20650 | 733097..733135 | + | 39 | WP_106019118.1 | hypothetical protein | - |
ASZ88_RS17490 | 733331..733777 | + | 447 | WP_000006157.1 | hypothetical protein | - |
ASZ88_RS17495 | 733925..734194 | - | 270 | WP_000277238.1 | type II toxin-antitoxin system YafQ family toxin | - |
ASZ88_RS17500 | 734187..734465 | - | 279 | WP_001258569.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
ASZ88_RS17505 | 734715..734972 | + | 258 | WP_000861987.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
ASZ88_RS17510 | 734960..735262 | + | 303 | WP_000229318.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
ASZ88_RS17515 | 735551..735775 | + | 225 | WP_001894423.1 | DUF3709 domain-containing protein | - |
ASZ88_RS17520 | 736219..736338 | + | 120 | WP_071919600.1 | DUF645 family protein | - |
ASZ88_RS20665 | 736342..736395 | + | 54 | Protein_681 | DUF645 family protein | - |
ASZ88_RS17535 | 736997..738001 | + | 1005 | WP_000964931.1 | LD-carboxypeptidase | - |
ASZ88_RS17545 | 738776..738956 | + | 181 | Protein_683 | DUF645 family protein | - |
ASZ88_RS17550 | 739223..739510 | + | 288 | WP_001162670.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
ASZ88_RS17555 | 739521..739838 | + | 318 | WP_001232701.1 | HigA family addiction module antidote protein | - |
ASZ88_RS21145 | 739835..739945 | + | 111 | WP_134814058.1 | DUF3265 domain-containing protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | catB9 | - | 688711..843534 | 154823 | |
- | inside | Integron | catB9 | - | 693791..843158 | 149367 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 101 a.a. Molecular weight: 11751.69 Da Isoelectric Point: 5.1972
>T58332 WP_000229318.1 NZ_CP013312:734960-735262 [Vibrio cholerae]
MVEIIWTEPALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRIPPELEHLNYREVVVNPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ
MVEIIWTEPALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRIPPELEHLNYREVVVNPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ
Download Length: 303 bp
>T58332 NZ_CP013312:734960-735262 [Vibrio cholerae]
ATGGTTGAAATAATTTGGACGGAGCCGGCTCTATCCGACCTGAATGATATTGCTGAATACATCGCGCTTGAAAATGTCGT
GGCTGCTAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCATCCCTC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAATCCGTGTCGTGTTTTCTACAAGTATGATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG
ATGGTTGAAATAATTTGGACGGAGCCGGCTCTATCCGACCTGAATGATATTGCTGAATACATCGCGCTTGAAAATGTCGT
GGCTGCTAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCATCCCTC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAATCCGTGTCGTGTTTTCTACAAGTATGATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG
Antitoxin
Download Length: 86 a.a. Molecular weight: 9647.15 Da Isoelectric Point: 7.3178
>AT58332 WP_000861987.1 NZ_CP013312:734715-734972 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK
Download Length: 258 bp
>AT58332 NZ_CP013312:734715-734972 [Vibrio cholerae]
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCCTGGAAGGTATTGCTCGCGGAGAGCGAGCTTTAGCGGATGGTAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGTTGAAATAA
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCCTGGAAGGTATTGCTCGCGGAGAGCGAGCTTTAGCGGATGGTAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGTTGAAATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | C3LV30 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1T4SLM9 |