Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 733925..734465 Replicon chromosome
Accession NZ_CP013312
Organism Vibrio cholerae strain E1320

Toxin (Protein)


Gene name relE Uniprot ID A0A151JGK8
Locus tag ASZ88_RS17495 Protein ID WP_000277238.1
Coordinates 733925..734194 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KML3
Locus tag ASZ88_RS17500 Protein ID WP_001258569.1
Coordinates 734187..734465 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASZ88_RS17440 728929..729171 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
ASZ88_RS17445 729415..729801 + 387 WP_001015867.1 NUDIX hydrolase -
ASZ88_RS17450 729858..729971 + 114 WP_001900214.1 hypothetical protein -
ASZ88_RS17455 729920..730201 + 282 WP_001894429.1 DUF1289 domain-containing protein -
ASZ88_RS17465 730459..730995 + 537 WP_000469482.1 GNAT family N-acetyltransferase -
ASZ88_RS17470 731132..731647 + 516 WP_001201509.1 lipocalin family protein -
ASZ88_RS17475 731797..732294 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
ASZ88_RS17480 732291..732563 - 273 WP_000246253.1 DUF1778 domain-containing protein -
ASZ88_RS20645 732956..733081 + 126 WP_001900195.1 DUF645 family protein -
ASZ88_RS20650 733097..733135 + 39 WP_106019118.1 hypothetical protein -
ASZ88_RS17490 733331..733777 + 447 WP_000006157.1 hypothetical protein -
ASZ88_RS17495 733925..734194 - 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin Toxin
ASZ88_RS17500 734187..734465 - 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
ASZ88_RS17505 734715..734972 + 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
ASZ88_RS17510 734960..735262 + 303 WP_000229318.1 type II toxin-antitoxin system RelE/ParE family toxin -
ASZ88_RS17515 735551..735775 + 225 WP_001894423.1 DUF3709 domain-containing protein -
ASZ88_RS17520 736219..736338 + 120 WP_071919600.1 DUF645 family protein -
ASZ88_RS20665 736342..736395 + 54 Protein_681 DUF645 family protein -
ASZ88_RS17535 736997..738001 + 1005 WP_000964931.1 LD-carboxypeptidase -
ASZ88_RS17545 738776..738956 + 181 Protein_683 DUF645 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 688711..843534 154823
- inside Integron catB9 - 693791..843158 149367


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10406.11 Da        Isoelectric Point: 9.5084

>T58331 WP_000277238.1 NZ_CP013312:c734194-733925 [Vibrio cholerae]
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF

Download         Length: 270 bp

>T58331 NZ_CP013312:c734194-733925 [Vibrio cholerae]
ATGTATAAACTCGAATACTCCACACAGTTTAAGAAAGATTTCAAAAAGATAACTAAGATGCCGATTTCAGACATCATTGA
AGTCGGCAATGTTATTTCTAAGCTGCAACGCGGCGAAAAGCTTGAACCCAAGAATGTTGACCATCCGTTAACTGGAAATT
GGGTTGGATTTCGAGACTGCCACATTAAACCCGACCTAGTGTTAATCTATCGAGTTTTTAACGATCAACTACAACTAGCG
CGCATTGGTTCACATAGTGATTTATTCTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10088.58 Da        Isoelectric Point: 6.0728

>AT58331 WP_001258569.1 NZ_CP013312:c734465-734187 [Vibrio cholerae]
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV

Download         Length: 279 bp

>AT58331 NZ_CP013312:c734465-734187 [Vibrio cholerae]
ATGAGAACAGAAATGCTGAGCACGCGCATTGACCACGACACGAAAATTGCGTTCACAAACGTCTGCGATGAGATGGGTCT
AAGTACATCACAGGCCATAAAGTTATTTGCAAAAGCGGTTATTAATCATGGTGGAATCCCTTTTGAGCTGCGAGTTCCAC
AGCCTAATGAGGTTACTGCATCTGCAATTCAAGAGCTCGTTGAAGGAAAAGGACATAAAGCTGAATCCGTTGAAGCTATG
CTGAATGAGCTTACTGAAGGCAAAGTTAAGCATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A151JGK8

Antitoxin

Source ID Structure
AlphaFold DB A0A151KTP9

References