58330

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 731797..732563 Replicon chromosome
Accession NZ_CP013312
Organism Vibrio cholerae strain E1320

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag ASZ88_RS17475 Protein ID WP_000982260.1
Coordinates 731797..732294 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag ASZ88_RS17480 Protein ID WP_000246253.1
Coordinates 732291..732563 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASZ88_RS17425 727239..727943 + 705 WP_000087610.1 HNH endonuclease -
ASZ88_RS17430 728101..728439 + 339 WP_000713853.1 hypothetical protein -
ASZ88_RS17435 728593..728910 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin -
ASZ88_RS17440 728929..729171 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
ASZ88_RS17445 729415..729801 + 387 WP_001015867.1 NUDIX hydrolase -
ASZ88_RS17450 729858..729971 + 114 WP_001900214.1 hypothetical protein -
ASZ88_RS17455 729920..730201 + 282 WP_001894429.1 DUF1289 domain-containing protein -
ASZ88_RS17465 730459..730995 + 537 WP_000469482.1 GNAT family N-acetyltransferase -
ASZ88_RS17470 731132..731647 + 516 WP_001201509.1 lipocalin family protein -
ASZ88_RS17475 731797..732294 - 498 WP_000982260.1 GNAT family N-acetyltransferase Toxin
ASZ88_RS17480 732291..732563 - 273 WP_000246253.1 DUF1778 domain-containing protein Antitoxin
ASZ88_RS20645 732956..733081 + 126 WP_001900195.1 DUF645 family protein -
ASZ88_RS20650 733097..733135 + 39 WP_106019118.1 hypothetical protein -
ASZ88_RS17490 733331..733777 + 447 WP_000006157.1 hypothetical protein -
ASZ88_RS17495 733925..734194 - 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin -
ASZ88_RS17500 734187..734465 - 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
ASZ88_RS17505 734715..734972 + 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
ASZ88_RS17510 734960..735262 + 303 WP_000229318.1 type II toxin-antitoxin system RelE/ParE family toxin -
ASZ88_RS17515 735551..735775 + 225 WP_001894423.1 DUF3709 domain-containing protein -
ASZ88_RS17520 736219..736338 + 120 WP_071919600.1 DUF645 family protein -
ASZ88_RS20665 736342..736395 + 54 Protein_681 DUF645 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 688711..843534 154823
- inside Integron catB9 - 693791..843158 149367


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T58330 WP_000982260.1 NZ_CP013312:c732294-731797 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T58330 NZ_CP013312:c732294-731797 [Vibrio cholerae]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT58330 WP_000246253.1 NZ_CP013312:c732563-732291 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT58330 NZ_CP013312:c732563-732291 [Vibrio cholerae]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0KGB1

Antitoxin

Source ID Structure
AlphaFold DB A0A0F2IC79

References