58327

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DhiAT/-
Location 709857..710641 Replicon chromosome
Accession NZ_CP013312
Organism Vibrio cholerae strain E1320

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag ASZ88_RS17285 Protein ID WP_001114075.1
Coordinates 709857..710126 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name dhiA Uniprot ID C3LUY7
Locus tag ASZ88_RS17290 Protein ID WP_000921692.1
Coordinates 710120..710641 (+) Length 174 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASZ88_RS17225 705267..705566 - 300 WP_000802136.1 type II toxin-antitoxin system RelE/ParE family toxin -
ASZ88_RS17230 705563..705805 - 243 WP_001107719.1 type II toxin-antitoxin system ParD family antitoxin -
ASZ88_RS17240 706224..706301 + 78 WP_071908337.1 DUF645 family protein -
ASZ88_RS21055 706305..706331 + 27 Protein_629 hypothetical protein -
ASZ88_RS21140 706917..707060 + 144 WP_001900215.1 hypothetical protein -
ASZ88_RS20580 707154..707333 + 180 Protein_631 DUF645 family protein -
ASZ88_RS17265 707551..707979 + 429 WP_000620002.1 N-acetyltransferase -
ASZ88_RS17275 708567..709049 + 483 WP_000422940.1 GNAT family N-acetyltransferase -
ASZ88_RS17285 709857..710126 + 270 WP_001114075.1 DUF4160 domain-containing protein Toxin
ASZ88_RS17290 710120..710641 + 522 WP_000921692.1 DUF2442 domain-containing protein Antitoxin
ASZ88_RS20220 710698..710811 + 114 WP_001894981.1 hypothetical protein -
ASZ88_RS17295 710780..711616 + 837 WP_000242986.1 hypothetical protein -
ASZ88_RS17300 711781..712419 + 639 WP_000230118.1 HD domain-containing protein -
ASZ88_RS20595 712509..712669 + 161 Protein_639 DUF3709 domain-containing protein -
ASZ88_RS17305 712690..712911 + 222 WP_012705854.1 DUF3709 domain-containing protein -
ASZ88_RS17315 713231..713551 + 321 WP_001909340.1 DUF1778 domain-containing protein -
ASZ88_RS17320 713548..714081 + 534 WP_000118351.1 GNAT family N-acetyltransferase -
ASZ88_RS17325 714319..714597 + 279 WP_000280324.1 DUF3709 domain-containing protein -
ASZ88_RS17330 714998..715222 + 225 WP_001894423.1 DUF3709 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 688711..843534 154823
- inside Integron catB9 - 693791..843158 149367


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin

Protein of unknown function DUF2442

(4-59)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T58327 WP_001114075.1 NZ_CP013312:709857-710126 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T58327 NZ_CP013312:709857-710126 [Vibrio cholerae]
ATGCCAGAGATTGATGCCCTATTAGGCCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTGCCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAAC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA

Antitoxin


Download         Length: 174 a.a.        Molecular weight: 19439.04 Da        Isoelectric Point: 6.7342

>AT58327 WP_000921692.1 NZ_CP013312:710120-710641 [Vibrio cholerae]
MLKVIDVDFVSDHTLELTFNDGYQGYADLSVYFKKTPFSEIKDFKRFSLTRDGSLNWDGNELTAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQFGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI

Download         Length: 522 bp

>AT58327 NZ_CP013312:710120-710641 [Vibrio cholerae]
ATGTTGAAAGTCATAGATGTTGATTTTGTCTCAGACCATACATTAGAACTGACGTTCAATGATGGTTACCAAGGCTATGC
CGACTTGTCGGTATACTTTAAAAAAACACCGTTTTCAGAAATTAAGGACTTTAAACGCTTTTCCTTGACTCGTGATGGCT
CGTTAAATTGGGATGGTAATGAGTTAACGGCCGCGACACTCCGTGACATAACCAAGGGCTCACAAAAGTCGGTGGAGTTA
AGTTTTAATGTTCAAGAAATGGAAGCCGTCATCAAACAGGCCTCATGGGAATCGATGATGGAGGGGCGTCCCGACATCTT
GCAAGCGGCTATTCGTTCTTACGTAGAGCAGTTTGGTCATGGTCAAGTTATTGCAAAGGCGGGTATAAAAAGTCGTACGA
GTGCTTATCGCTCCTTGAAGCCAGAAACAACGCCAAACTTTGGCACACTAGTTCAGTTAGGGCACGCCGTCATCGAACTA
GCGAAAGATAGAACAGTGGCAAACAAGGAACCACGCATATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A086SLD6

Antitoxin

Source ID Structure
AlphaFold DB C3LUY7

References