Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 705267..705805 | Replicon | chromosome |
| Accession | NZ_CP013312 | ||
| Organism | Vibrio cholerae strain E1320 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | Q9KMJ0 |
| Locus tag | ASZ88_RS17225 | Protein ID | WP_000802136.1 |
| Coordinates | 705267..705566 (-) | Length | 100 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | P58093 |
| Locus tag | ASZ88_RS17230 | Protein ID | WP_001107719.1 |
| Coordinates | 705563..705805 (-) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ASZ88_RS17160 | 700713..700895 | + | 183 | WP_000923153.1 | DUF645 family protein | - |
| ASZ88_RS17165 | 701148..701399 | + | 252 | WP_001890111.1 | TIGR03643 family protein | - |
| ASZ88_RS17170 | 701372..701521 | + | 150 | WP_071908333.1 | DUF3265 domain-containing protein | - |
| ASZ88_RS17175 | 701531..702046 | + | 516 | WP_000090011.1 | hypothetical protein | - |
| ASZ88_RS17180 | 702181..702717 | + | 537 | WP_000644491.1 | nucleotidyltransferase family protein | - |
| ASZ88_RS21135 | 702836..702997 | + | 162 | WP_000481782.1 | hypothetical protein | - |
| ASZ88_RS17185 | 703186..703296 | + | 111 | WP_071908335.1 | DUF3265 domain-containing protein | - |
| ASZ88_RS17195 | 703509..703661 | + | 153 | WP_001884520.1 | DUF645 family protein | - |
| ASZ88_RS17200 | 703945..704388 | + | 444 | WP_000803902.1 | hypothetical protein | - |
| ASZ88_RS17205 | 704392..704502 | + | 111 | WP_071908336.1 | DUF3265 domain-containing protein | - |
| ASZ88_RS17210 | 704532..704810 | - | 279 | WP_000578476.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | - |
| ASZ88_RS17215 | 704807..705091 | - | 285 | WP_000381183.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
| ASZ88_RS17225 | 705267..705566 | - | 300 | WP_000802136.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| ASZ88_RS17230 | 705563..705805 | - | 243 | WP_001107719.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| ASZ88_RS17240 | 706224..706301 | + | 78 | WP_071908337.1 | DUF645 family protein | - |
| ASZ88_RS21055 | 706305..706331 | + | 27 | Protein_629 | hypothetical protein | - |
| ASZ88_RS21140 | 706917..707060 | + | 144 | WP_001900215.1 | hypothetical protein | - |
| ASZ88_RS20580 | 707154..707333 | + | 180 | Protein_631 | DUF645 family protein | - |
| ASZ88_RS17265 | 707551..707979 | + | 429 | WP_000620002.1 | N-acetyltransferase | - |
| ASZ88_RS17275 | 708567..709049 | + | 483 | WP_000422940.1 | GNAT family N-acetyltransferase | - |
| ASZ88_RS17285 | 709857..710126 | + | 270 | WP_001114075.1 | DUF4160 domain-containing protein | - |
| ASZ88_RS17290 | 710120..710641 | + | 522 | WP_000921692.1 | DUF2442 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | catB9 | - | 688711..843534 | 154823 | |
| - | inside | Integron | catB9 | - | 693791..843158 | 149367 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 100 a.a. Molecular weight: 11589.29 Da Isoelectric Point: 9.9232
>T58326 WP_000802136.1 NZ_CP013312:c705566-705267 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA
Download Length: 300 bp
>T58326 NZ_CP013312:c705566-705267 [Vibrio cholerae]
ATGAAACCATTTAATCTTACCGTCGCCGCCAAAGCCGATTTACGTGATATTGCTTTATTCACTCAACGACGCTGGGGAAA
AGAGCAGCGAAATGTTTATTTAAAGCAATTCGATGATTCCTTTTGGCTTTTAGCGGAAAATCCCGACATTGGTAAATCAT
GCGATGAAATCCGAGAGGGATACAGAAAATTTCCCCAAGGGAGTCACGTCATCTTTTATCAGCAAACCGGCAGCCAACAA
ATCCGGGTGATCCGAATTCTTCATAAGAGCATGGATGTGAACCCAATATTCGGCGCATAA
ATGAAACCATTTAATCTTACCGTCGCCGCCAAAGCCGATTTACGTGATATTGCTTTATTCACTCAACGACGCTGGGGAAA
AGAGCAGCGAAATGTTTATTTAAAGCAATTCGATGATTCCTTTTGGCTTTTAGCGGAAAATCCCGACATTGGTAAATCAT
GCGATGAAATCCGAGAGGGATACAGAAAATTTCCCCAAGGGAGTCACGTCATCTTTTATCAGCAAACCGGCAGCCAACAA
ATCCGGGTGATCCGAATTCTTCATAAGAGCATGGATGTGAACCCAATATTCGGCGCATAA
Antitoxin
Download Length: 81 a.a. Molecular weight: 8964.84 Da Isoelectric Point: 4.1677
>AT58326 WP_001107719.1 NZ_CP013312:c705805-705563 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR
Download Length: 243 bp
>AT58326 NZ_CP013312:c705805-705563 [Vibrio cholerae]
ATGGCTAAAAATACAAGTATCACTCTTGGTGAACACTTCGATGGCTTTATTACAAGCCAAATACAAAGTGGGCGTTACGG
CTCAGCAAGTGAAGTCATTCGCTCTGCGCTACGTCTACTCGAAAACCAAGAAACCAAACTACAGTCACTCCGTCAACTAC
TTATTGAAGGAGAGCAAAGTGGTGACGCTGATTATGACCTTGATAGCTTCATCAATGAACTCGATAGTGAAAACATTCGA
TGA
ATGGCTAAAAATACAAGTATCACTCTTGGTGAACACTTCGATGGCTTTATTACAAGCCAAATACAAAGTGGGCGTTACGG
CTCAGCAAGTGAAGTCATTCGCTCTGCGCTACGTCTACTCGAAAACCAAGAAACCAAACTACAGTCACTCCGTCAACTAC
TTATTGAAGGAGAGCAAAGTGGTGACGCTGATTATGACCTTGATAGCTTCATCAATGAACTCGATAGTGAAAACATTCGA
TGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|