Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 704532..705091 Replicon chromosome
Accession NZ_CP013312
Organism Vibrio cholerae strain E1320

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag ASZ88_RS17210 Protein ID WP_000578476.1
Coordinates 704532..704810 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag ASZ88_RS17215 Protein ID WP_000381183.1
Coordinates 704807..705091 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASZ88_RS17155 699985..700419 + 435 WP_000453680.1 GNAT family N-acetyltransferase -
ASZ88_RS17160 700713..700895 + 183 WP_000923153.1 DUF645 family protein -
ASZ88_RS17165 701148..701399 + 252 WP_001890111.1 TIGR03643 family protein -
ASZ88_RS17170 701372..701521 + 150 WP_071908333.1 DUF3265 domain-containing protein -
ASZ88_RS17175 701531..702046 + 516 WP_000090011.1 hypothetical protein -
ASZ88_RS17180 702181..702717 + 537 WP_000644491.1 nucleotidyltransferase family protein -
ASZ88_RS21135 702836..702997 + 162 WP_000481782.1 hypothetical protein -
ASZ88_RS17185 703186..703296 + 111 WP_071908335.1 DUF3265 domain-containing protein -
ASZ88_RS17195 703509..703661 + 153 WP_001884520.1 DUF645 family protein -
ASZ88_RS17200 703945..704388 + 444 WP_000803902.1 hypothetical protein -
ASZ88_RS17205 704392..704502 + 111 WP_071908336.1 DUF3265 domain-containing protein -
ASZ88_RS17210 704532..704810 - 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
ASZ88_RS17215 704807..705091 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
ASZ88_RS17225 705267..705566 - 300 WP_000802136.1 type II toxin-antitoxin system RelE/ParE family toxin -
ASZ88_RS17230 705563..705805 - 243 WP_001107719.1 type II toxin-antitoxin system ParD family antitoxin -
ASZ88_RS17240 706224..706301 + 78 WP_071908337.1 DUF645 family protein -
ASZ88_RS21055 706305..706331 + 27 Protein_629 hypothetical protein -
ASZ88_RS21140 706917..707060 + 144 WP_001900215.1 hypothetical protein -
ASZ88_RS20580 707154..707333 + 180 Protein_631 DUF645 family protein -
ASZ88_RS17265 707551..707979 + 429 WP_000620002.1 N-acetyltransferase -
ASZ88_RS17275 708567..709049 + 483 WP_000422940.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 688711..843534 154823
- inside Integron catB9 - 693791..843158 149367


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T58325 WP_000578476.1 NZ_CP013312:c704810-704532 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T58325 NZ_CP013312:c704810-704532 [Vibrio cholerae]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT58325 WP_000381183.1 NZ_CP013312:c705091-704807 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT58325 NZ_CP013312:c705091-704807 [Vibrio cholerae]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9K2M8

Antitoxin

Source ID Structure
AlphaFold DB A0A067BL33

References