58298

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DhiAT/-
Location 446934..447718 Replicon chromosome
Accession NZ_CP013308
Organism Vibrio cholerae strain E506

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag ASZ84_RS16790 Protein ID WP_001114075.1
Coordinates 446934..447203 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name dhiA Uniprot ID Q9KM84
Locus tag ASZ84_RS16795 Protein ID WP_000921691.1
Coordinates 447197..447718 (+) Length 174 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASZ84_RS16740 442268..442555 + 288 WP_000426470.1 hypothetical protein -
ASZ84_RS16745 442696..443067 + 372 WP_001164080.1 nucleotide pyrophosphohydrolase -
ASZ84_RS16750 443134..443559 + 426 WP_001882332.1 DUF1778 domain-containing protein -
ASZ84_RS16755 443556..444089 + 534 WP_000118351.1 GNAT family N-acetyltransferase -
ASZ84_RS16760 444291..444548 + 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
ASZ84_RS16765 444536..444838 + 303 WP_000229317.1 type II toxin-antitoxin system RelE/ParE family toxin -
ASZ84_RS16775 445109..445993 + 885 WP_000842472.1 DUF3800 domain-containing protein -
ASZ84_RS16780 446143..446742 + 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
ASZ84_RS20165 446799..446903 + 105 WP_099607150.1 acetyltransferase -
ASZ84_RS16790 446934..447203 + 270 WP_001114075.1 DUF4160 domain-containing protein Toxin
ASZ84_RS16795 447197..447718 + 522 WP_000921691.1 DUF2442 domain-containing protein Antitoxin
ASZ84_RS20170 448017..448142 + 126 WP_001905700.1 DUF645 family protein -
ASZ84_RS16805 448393..448788 + 396 WP_001000867.1 hypothetical protein -
ASZ84_RS16810 448927..449205 - 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
ASZ84_RS16815 449202..449486 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
ASZ84_RS16820 449680..450195 + 516 WP_000343779.1 GNAT family N-acetyltransferase -
ASZ84_RS16825 450379..450792 + 414 WP_000049420.1 VOC family protein -
ASZ84_RS16835 451347..452524 + 1178 WP_086010879.1 IS3-like element ISVch4 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 309168..451279 142111
- inside Genomic island - - 304088..451655 147567


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin

Protein of unknown function DUF2442

(4-59)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T58298 WP_001114075.1 NZ_CP013308:446934-447203 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T58298 NZ_CP013308:446934-447203 [Vibrio cholerae]
ATGCCAGAGATTGATGCCCTATTAGGTCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTACCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAGC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA

Antitoxin


Download         Length: 174 a.a.        Molecular weight: 19409.01 Da        Isoelectric Point: 6.7342

>AT58298 WP_000921691.1 NZ_CP013308:447197-447718 [Vibrio cholerae]
MLKVIDVDFVSDHTLELTFNDGYQGYADLSVYFKKAPFSEIKDFKRFSLTRDGSLNWDGNELTAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQFGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI

Download         Length: 522 bp

>AT58298 NZ_CP013308:447197-447718 [Vibrio cholerae]
ATGTTGAAAGTCATAGATGTTGATTTTGTCTCAGACCATACATTAGAACTGACGTTCAATGATGGTTACCAAGGCTATGC
CGACTTGTCGGTATACTTTAAAAAAGCACCGTTTTCAGAAATTAAGGACTTTAAACGCTTTTCCTTGACTCGTGATGGCT
CGTTAAATTGGGATGGTAATGAGTTAACGGCCGCGACACTCCGTGACATAACCAAGGGCTCACAAAAGTCGGTGGAGTTA
AGTTTTAATGTTCAAGAAATGGAAGCCGTCATCAAACAGGCCTCATGGGAATCGATGATGGAGGGGCGTCCCGACATCTT
GCAAGCGGCTATTCGTTCTTACGTAGAGCAGTTTGGTCATGGTCAAGTTATTGCAAAGGCGGGTATAAAAAGTCGTACGA
GTGCTTATCGCTCCTTGAAGCCAGAAACAACGCCAAACTTTGGCACACTAGTTCAGTTAGGGCACGCCGTCATCGAACTA
GCGAAAGATAGAACAGTGGCAAACAAGGAACCACGCATATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A086SLD6

Antitoxin

Source ID Structure
AlphaFold DB Q9KM84

References