58296

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 444291..444838 Replicon chromosome
Accession NZ_CP013308
Organism Vibrio cholerae strain E506

Toxin (Protein)


Gene name relE Uniprot ID Q9KM92
Locus tag ASZ84_RS16765 Protein ID WP_000229317.1
Coordinates 444536..444838 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag ASZ84_RS16760 Protein ID WP_000861987.1
Coordinates 444291..444548 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASZ84_RS16705 439320..439775 + 456 WP_001245327.1 GNAT family N-acetyltransferase -
ASZ84_RS16715 440097..440249 + 153 WP_001884520.1 DUF645 family protein -
ASZ84_RS16720 440451..440948 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
ASZ84_RS16725 440945..441217 - 273 WP_000246253.1 DUF1778 domain-containing protein -
ASZ84_RS16735 441448..442116 + 669 WP_000043871.1 hypothetical protein -
ASZ84_RS16740 442268..442555 + 288 WP_000426470.1 hypothetical protein -
ASZ84_RS16745 442696..443067 + 372 WP_001164080.1 nucleotide pyrophosphohydrolase -
ASZ84_RS16750 443134..443559 + 426 WP_001882332.1 DUF1778 domain-containing protein -
ASZ84_RS16755 443556..444089 + 534 WP_000118351.1 GNAT family N-acetyltransferase -
ASZ84_RS16760 444291..444548 + 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ASZ84_RS16765 444536..444838 + 303 WP_000229317.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ASZ84_RS16775 445109..445993 + 885 WP_000842472.1 DUF3800 domain-containing protein -
ASZ84_RS16780 446143..446742 + 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
ASZ84_RS20165 446799..446903 + 105 WP_099607150.1 acetyltransferase -
ASZ84_RS16790 446934..447203 + 270 WP_001114075.1 DUF4160 domain-containing protein -
ASZ84_RS16795 447197..447718 + 522 WP_000921691.1 DUF2442 domain-containing protein -
ASZ84_RS20170 448017..448142 + 126 WP_001905700.1 DUF645 family protein -
ASZ84_RS16805 448393..448788 + 396 WP_001000867.1 hypothetical protein -
ASZ84_RS16810 448927..449205 - 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
ASZ84_RS16815 449202..449486 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 304088..451655 147567
- inside Integron - - 309168..451279 142111


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11726.68 Da        Isoelectric Point: 5.1972

>T58296 WP_000229317.1 NZ_CP013308:444536-444838 [Vibrio cholerae]
MVEIIWTELALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T58296 NZ_CP013308:444536-444838 [Vibrio cholerae]
ATGGTTGAAATAATTTGGACGGAGCTGGCTCTATCCGACTTGAATGATATTGCTGAATACATCGCGCTTGAAAATGTCGT
GGCTGCTAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCGTCCCTC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAGTCCGTGTCGTGTTTTCTACAAGTATGATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT58296 WP_000861987.1 NZ_CP013308:444291-444548 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT58296 NZ_CP013308:444291-444548 [Vibrio cholerae]
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCCTGGAAGGTATTGCTCGCGGAGAGCGAGCTTTAGCGGATGGTAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGTTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9KM92

Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SLM9

References