Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /DUF1778(antitoxin) |
| Location | 363318..364168 | Replicon | chromosome |
| Accession | NZ_CP013308 | ||
| Organism | Vibrio cholerae strain E506 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | Q9KM94 |
| Locus tag | ASZ84_RS15910 | Protein ID | WP_000118351.1 |
| Coordinates | 363635..364168 (+) | Length | 178 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | ASZ84_RS15905 | Protein ID | WP_001909340.1 |
| Coordinates | 363318..363638 (+) | Length | 107 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ASZ84_RS15855 | 358654..359136 | + | 483 | WP_000422940.1 | GNAT family N-acetyltransferase | - |
| ASZ84_RS15870 | 359944..360213 | + | 270 | WP_001114075.1 | DUF4160 domain-containing protein | - |
| ASZ84_RS15875 | 360207..360728 | + | 522 | WP_000921692.1 | DUF2442 domain-containing protein | - |
| ASZ84_RS15880 | 360785..360898 | + | 114 | WP_001894981.1 | hypothetical protein | - |
| ASZ84_RS15885 | 360867..361703 | + | 837 | WP_000242986.1 | hypothetical protein | - |
| ASZ84_RS15890 | 361868..362506 | + | 639 | WP_000230118.1 | HD domain-containing protein | - |
| ASZ84_RS19970 | 362596..362756 | + | 161 | Protein_340 | DUF3709 domain-containing protein | - |
| ASZ84_RS15895 | 362777..362998 | + | 222 | WP_012705854.1 | DUF3709 domain-containing protein | - |
| ASZ84_RS15905 | 363318..363638 | + | 321 | WP_001909340.1 | DUF1778 domain-containing protein | Antitoxin |
| ASZ84_RS15910 | 363635..364168 | + | 534 | WP_000118351.1 | GNAT family N-acetyltransferase | Toxin |
| ASZ84_RS15915 | 364406..364684 | + | 279 | WP_000280324.1 | DUF3709 domain-containing protein | - |
| ASZ84_RS20420 | 365059..365202 | + | 144 | Protein_345 | DUF645 family protein | - |
| ASZ84_RS20425 | 365256..365294 | + | 39 | WP_082798268.1 | hypothetical protein | - |
| ASZ84_RS15935 | 365506..365973 | + | 468 | WP_001289288.1 | OsmC family protein | - |
| ASZ84_RS15940 | 366101..366763 | + | 663 | WP_000960654.1 | hypothetical protein | - |
| ASZ84_RS15945 | 366948..367214 | + | 267 | WP_000589156.1 | BrnT family toxin | - |
| ASZ84_RS15950 | 367201..367446 | + | 246 | WP_000643598.1 | hypothetical protein | - |
| ASZ84_RS15955 | 367542..368336 | + | 795 | WP_001911581.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 304088..451655 | 147567 | |
| - | inside | Integron | - | - | 309168..451279 | 142111 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 178 a.a. Molecular weight: 20171.46 Da Isoelectric Point: 9.1432
>T58286 WP_000118351.1 NZ_CP013308:363635-364168 [Vibrio cholerae]
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAHPLLNQKFAICAFYSVAPSSISRETLPA
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNE
RIRMFLPMKTVEQLFNQ
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAHPLLNQKFAICAFYSVAPSSISRETLPA
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNE
RIRMFLPMKTVEQLFNQ
Download Length: 534 bp
>T58286 NZ_CP013308:363635-364168 [Vibrio cholerae]
GTGAGTTGGGGCAAAGAGTTTGTAGAACTTAGTAAATCAAAGCATGACCGCGACTCATTTGACTGTGGTGAGCAAGAGCT
AAACACATTTATCAAAACTCAAGCTGCAAAGCACATGCAAGCAGGTATTAGTCGAACAATGGTTTTACCTAGTGCTCACC
CACTGTTAAATCAAAAATTCGCTATTTGTGCCTTTTATAGTGTTGCACCGAGCTCAATCAGCCGAGAAACATTACCGGCA
CAATTAGCAAAGAAACTACCGAGGTATCCAATCCCTGTTTTTCTGTTGGCTCAGTTAGCTGTGCACAAAGAATTTCACGG
TTCTGGACTTGGAAAGGTCAGTCTAATCCGTGCGCTGAAGTACTTGTGGGAAGTGAATCATCACATGAGAGCATATGCAA
TAGTTGTGGATTGTCTGACAGATTCCGCTCAAGCGTTCTATACGAAGTTCGGCTTTGAAGTATTGTGCGAACATAATGAG
CGTATTCGTATGTTCTTACCGATGAAAACGGTAGAACAACTTTTTAATCAATAG
GTGAGTTGGGGCAAAGAGTTTGTAGAACTTAGTAAATCAAAGCATGACCGCGACTCATTTGACTGTGGTGAGCAAGAGCT
AAACACATTTATCAAAACTCAAGCTGCAAAGCACATGCAAGCAGGTATTAGTCGAACAATGGTTTTACCTAGTGCTCACC
CACTGTTAAATCAAAAATTCGCTATTTGTGCCTTTTATAGTGTTGCACCGAGCTCAATCAGCCGAGAAACATTACCGGCA
CAATTAGCAAAGAAACTACCGAGGTATCCAATCCCTGTTTTTCTGTTGGCTCAGTTAGCTGTGCACAAAGAATTTCACGG
TTCTGGACTTGGAAAGGTCAGTCTAATCCGTGCGCTGAAGTACTTGTGGGAAGTGAATCATCACATGAGAGCATATGCAA
TAGTTGTGGATTGTCTGACAGATTCCGCTCAAGCGTTCTATACGAAGTTCGGCTTTGAAGTATTGTGCGAACATAATGAG
CGTATTCGTATGTTCTTACCGATGAAAACGGTAGAACAACTTTTTAATCAATAG
Antitoxin
Download Length: 107 a.a. Molecular weight: 11759.53 Da Isoelectric Point: 4.9309
>AT58286 WP_001909340.1 NZ_CP013308:363318-363638 [Vibrio cholerae]
MAYNRSTDGMYPYAGGVMATARLDIRLDEEIKAKAEKASALLGLKSLTEYVVRLMDEDATHVIEEHESIMVKDSVFDEFM
AACNKVKAPNQALLEAVKFTEKSGIK
MAYNRSTDGMYPYAGGVMATARLDIRLDEEIKAKAEKASALLGLKSLTEYVVRLMDEDATHVIEEHESIMVKDSVFDEFM
AACNKVKAPNQALLEAVKFTEKSGIK
Download Length: 321 bp
>AT58286 NZ_CP013308:363318-363638 [Vibrio cholerae]
TTGGCCTATAATCGCTCAACTGACGGAATGTATCCGTACGCAGGAGGGGTTATGGCAACGGCACGTTTAGATATCCGCCT
TGATGAAGAGATCAAGGCAAAAGCCGAAAAGGCATCGGCTTTACTTGGTTTAAAAAGTCTCACTGAATATGTGGTGAGAC
TTATGGACGAAGATGCGACTCATGTTATTGAGGAGCATGAAAGTATTATGGTTAAAGACAGTGTTTTTGACGAGTTTATG
GCTGCGTGTAATAAAGTAAAAGCACCGAATCAAGCTTTGCTTGAAGCTGTTAAATTTACAGAGAAGAGCGGTATCAAGTG
A
TTGGCCTATAATCGCTCAACTGACGGAATGTATCCGTACGCAGGAGGGGTTATGGCAACGGCACGTTTAGATATCCGCCT
TGATGAAGAGATCAAGGCAAAAGCCGAAAAGGCATCGGCTTTACTTGGTTTAAAAAGTCTCACTGAATATGTGGTGAGAC
TTATGGACGAAGATGCGACTCATGTTATTGAGGAGCATGAAAGTATTATGGTTAAAGACAGTGTTTTTGACGAGTTTATG
GCTGCGTGTAATAAAGTAAAAGCACCGAATCAAGCTTTGCTTGAAGCTGTTAAATTTACAGAGAAGAGCGGTATCAAGTG
A
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|