58285

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DhiAT/-
Location 359944..360728 Replicon chromosome
Accession NZ_CP013308
Organism Vibrio cholerae strain E506

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag ASZ84_RS15870 Protein ID WP_001114075.1
Coordinates 359944..360213 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name dhiA Uniprot ID C3LUY7
Locus tag ASZ84_RS15875 Protein ID WP_000921692.1
Coordinates 360207..360728 (+) Length 174 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASZ84_RS15815 355393..355494 + 102 WP_079993098.1 DUF3265 domain-containing protein -
ASZ84_RS15825 355662..355844 + 183 WP_000923182.1 DUF645 family protein -
ASZ84_RS15830 356060..357064 + 1005 WP_000964920.1 LD-carboxypeptidase -
ASZ84_RS15840 357638..358066 + 429 WP_000620002.1 N-acetyltransferase -
ASZ84_RS15855 358654..359136 + 483 WP_000422940.1 GNAT family N-acetyltransferase -
ASZ84_RS15870 359944..360213 + 270 WP_001114075.1 DUF4160 domain-containing protein Toxin
ASZ84_RS15875 360207..360728 + 522 WP_000921692.1 DUF2442 domain-containing protein Antitoxin
ASZ84_RS15880 360785..360898 + 114 WP_001894981.1 hypothetical protein -
ASZ84_RS15885 360867..361703 + 837 WP_000242986.1 hypothetical protein -
ASZ84_RS15890 361868..362506 + 639 WP_000230118.1 HD domain-containing protein -
ASZ84_RS19970 362596..362756 + 161 Protein_340 DUF3709 domain-containing protein -
ASZ84_RS15895 362777..362998 + 222 WP_012705854.1 DUF3709 domain-containing protein -
ASZ84_RS15905 363318..363638 + 321 WP_001909340.1 DUF1778 domain-containing protein -
ASZ84_RS15910 363635..364168 + 534 WP_000118351.1 GNAT family N-acetyltransferase -
ASZ84_RS15915 364406..364684 + 279 WP_000280324.1 DUF3709 domain-containing protein -
ASZ84_RS20420 365059..365202 + 144 Protein_345 DUF645 family protein -
ASZ84_RS20425 365256..365294 + 39 WP_082798268.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 304088..451655 147567
- inside Integron - - 309168..451279 142111


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin

Protein of unknown function DUF2442

(4-59)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T58285 WP_001114075.1 NZ_CP013308:359944-360213 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T58285 NZ_CP013308:359944-360213 [Vibrio cholerae]
ATGCCAGAGATTGATGCCCTATTAGGCCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTGCCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAAC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA

Antitoxin


Download         Length: 174 a.a.        Molecular weight: 19439.04 Da        Isoelectric Point: 6.7342

>AT58285 WP_000921692.1 NZ_CP013308:360207-360728 [Vibrio cholerae]
MLKVIDVDFVSDHTLELTFNDGYQGYADLSVYFKKTPFSEIKDFKRFSLTRDGSLNWDGNELTAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQFGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI

Download         Length: 522 bp

>AT58285 NZ_CP013308:360207-360728 [Vibrio cholerae]
ATGTTGAAAGTCATAGATGTTGATTTTGTCTCAGACCATACATTAGAACTGACGTTCAATGATGGTTACCAAGGCTATGC
CGACTTGTCGGTATACTTTAAAAAAACACCGTTTTCAGAAATTAAGGACTTTAAACGCTTTTCCTTGACTCGTGATGGCT
CGTTAAATTGGGATGGTAATGAGTTAACGGCCGCGACACTCCGTGACATAACCAAGGGCTCACAAAAGTCGGTGGAGTTA
AGTTTTAATGTTCAAGAAATGGAAGCCGTCATCAAACAGGCCTCATGGGAATCGATGATGGAGGGGCGTCCCGACATCTT
GCAAGCGGCTATTCGTTCTTACGTAGAGCAGTTTGGTCATGGTCAAGTTATTGCAAAGGCGGGTATAAAAAGTCGTACGA
GTGCTTATCGCTCCTTGAAGCCAGAAACAACGCCAAACTTTGGCACACTAGTTCAGTTAGGGCACGCCGTCATCGAACTA
GCGAAAGATAGAACAGTGGCAAACAAGGAACCACGCATATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A086SLD6

Antitoxin

Source ID Structure
AlphaFold DB C3LUY7

References