Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/YafQ-RelB |
| Location | 326253..326793 | Replicon | chromosome |
| Accession | NZ_CP013308 | ||
| Organism | Vibrio cholerae strain E506 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | A0A151JGK8 |
| Locus tag | ASZ84_RS15525 | Protein ID | WP_000277238.1 |
| Coordinates | 326253..326522 (-) | Length | 90 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | Q9KML3 |
| Locus tag | ASZ84_RS15530 | Protein ID | WP_001258569.1 |
| Coordinates | 326515..326793 (-) | Length | 93 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ASZ84_RS15475 | 321281..321424 | + | 144 | WP_021448843.1 | DUF3265 domain-containing protein | - |
| ASZ84_RS15480 | 321459..322229 | + | 771 | WP_000399050.1 | hypothetical protein | - |
| ASZ84_RS15485 | 322368..322751 | + | 384 | WP_000473945.1 | hypothetical protein | - |
| ASZ84_RS15490 | 322780..322857 | + | 78 | WP_080314602.1 | DUF3265 domain-containing protein | - |
| ASZ84_RS15495 | 322884..323357 | + | 474 | WP_001894959.1 | GrpB family protein | - |
| ASZ84_RS15500 | 323498..323935 | + | 438 | WP_001894912.1 | hypothetical protein | - |
| ASZ84_RS15505 | 324085..324336 | + | 252 | WP_001128284.1 | hypothetical protein | - |
| ASZ84_RS15510 | 324521..325036 | + | 516 | WP_001894921.1 | lipocalin family protein | - |
| ASZ84_RS20410 | 325411..325521 | + | 111 | WP_080314579.1 | DUF645 family protein | - |
| ASZ84_RS15520 | 325875..326056 | + | 182 | Protein_281 | DUF645 family protein | - |
| ASZ84_RS15525 | 326253..326522 | - | 270 | WP_000277238.1 | type II toxin-antitoxin system YafQ family toxin | Toxin |
| ASZ84_RS15530 | 326515..326793 | - | 279 | WP_001258569.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| ASZ84_RS15535 | 327148..327327 | + | 180 | Protein_284 | DUF645 family protein | - |
| ASZ84_RS15540 | 327577..328290 | + | 714 | WP_000123659.1 | Fic family protein | - |
| ASZ84_RS15555 | 328594..328764 | + | 171 | WP_000483442.1 | DUF645 family protein | - |
| ASZ84_RS15560 | 328976..329599 | + | 624 | WP_000247072.1 | DUF1349 domain-containing protein | - |
| ASZ84_RS15565 | 329756..330190 | + | 435 | WP_000453680.1 | GNAT family N-acetyltransferase | - |
| ASZ84_RS15570 | 330383..331294 | + | 912 | WP_000174843.1 | hypothetical protein | - |
| ASZ84_RS15575 | 331615..331767 | + | 153 | WP_001884520.1 | DUF645 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 304088..451655 | 147567 | |
| - | inside | Integron | - | - | 309168..451279 | 142111 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 90 a.a. Molecular weight: 10406.11 Da Isoelectric Point: 9.5084
>T58283 WP_000277238.1 NZ_CP013308:c326522-326253 [Vibrio cholerae]
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF
Download Length: 270 bp
>T58283 NZ_CP013308:c326522-326253 [Vibrio cholerae]
ATGTATAAACTCGAATACTCCACACAGTTTAAGAAAGATTTCAAAAAGATAACTAAGATGCCGATTTCAGACATCATTGA
AGTCGGCAATGTTATTTCTAAGCTGCAACGCGGCGAAAAGCTTGAACCCAAGAATGTTGACCATCCGTTAACTGGAAATT
GGGTTGGATTTCGAGACTGCCACATTAAACCCGACCTAGTGTTAATCTATCGAGTTTTTAACGATCAACTACAACTAGCG
CGCATTGGTTCACATAGCGATTTATTCTAA
ATGTATAAACTCGAATACTCCACACAGTTTAAGAAAGATTTCAAAAAGATAACTAAGATGCCGATTTCAGACATCATTGA
AGTCGGCAATGTTATTTCTAAGCTGCAACGCGGCGAAAAGCTTGAACCCAAGAATGTTGACCATCCGTTAACTGGAAATT
GGGTTGGATTTCGAGACTGCCACATTAAACCCGACCTAGTGTTAATCTATCGAGTTTTTAACGATCAACTACAACTAGCG
CGCATTGGTTCACATAGCGATTTATTCTAA
Antitoxin
Download Length: 93 a.a. Molecular weight: 10088.58 Da Isoelectric Point: 6.0728
>AT58283 WP_001258569.1 NZ_CP013308:c326793-326515 [Vibrio cholerae]
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV
Download Length: 279 bp
>AT58283 NZ_CP013308:c326793-326515 [Vibrio cholerae]
ATGAGAACAGAAATGCTGAGCACGCGCATTGACCACGACACGAAAATTGCGTTCACAAACGTCTGCGATGAGATGGGTCT
AAGTACATCACAGGCCATTAAGTTATTTGCAAAAGCGGTTATTAATCATGGTGGAATCCCTTTTGAGCTGCGAGTTCCAC
AGCCTAATGAGGTTACTGCATCTGCAATTCAAGAGCTCGTTGAAGGAAAAGGACATAAAGCTGAATCCGTTGAAGCTATG
CTGAATGAGCTTACTGAAGGCAAAGTTAAGCATGTATAA
ATGAGAACAGAAATGCTGAGCACGCGCATTGACCACGACACGAAAATTGCGTTCACAAACGTCTGCGATGAGATGGGTCT
AAGTACATCACAGGCCATTAAGTTATTTGCAAAAGCGGTTATTAATCATGGTGGAATCCCTTTTGAGCTGCGAGTTCCAC
AGCCTAATGAGGTTACTGCATCTGCAATTCAAGAGCTCGTTGAAGGAAAAGGACATAAAGCTGAATCCGTTGAAGCTATG
CTGAATGAGCTTACTGAAGGCAAAGTTAAGCATGTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A151JGK8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A151KTP9 |