Detailed information of TA system TA058211

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-yefM/YoeB-YefM
• Location: 27789..28300
• Replicon: plasmid unnamed 1
• Accession: NZ_CP013298
• Organism: Arthrobacter sp. YC-RL1

Toxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: ATC04_RS17935
• Protein ID: WP_047117799.1
• Coordinates: 27789..28055 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A365Y8H3
• Locus tag: ATC04_RS17940
• Protein ID: WP_022876888.1
• Coordinates: 28052..28300 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ATC04_RS17925	23710..25581	+	1872	WP_082123738.1	AAA family ATPase	-
ATC04_RS17930	25591..27285	+	1695	WP_052772176.1	ATP-dependent helicase	-
ATC04_RS17935	27789..28055	-	267	WP_047117799.1	Txe/YoeB family addiction module toxin	Toxin
ATC04_RS17940	28052..28300	-	249	WP_022876888.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
ATC04_RS19040	28443..29579	+	1137	WP_082123739.1	ferrochelatase	-
ATC04_RS19580	29761..29910	-	150	WP_152666744.1	cold shock domain-containing protein	-
ATC04_RS17950	29931..31490	-	1560	WP_047117835.1	molybdopterin-dependent oxidoreductase	-
ATC04_RS17955	31630..32436	-	807	WP_047117801.1	anti-sigma factor	-
ATC04_RS17960	32436..33014	-	579	WP_047117802.1	sigma-70 family RNA polymerase sigma factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..112763	112763

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-69)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10299.70 Da
• Isoelectric Point: 6.4589

>T58211 WP_047117799.1 NZ_CP013298:c28055-27789 [Arthrobacter sp. YC-RL1]
VSDRLLTWTTGGWEDYVCWQTQDRKTLKRINLLIEDVLRDDPFEGIGKPEPLKHALAGAWSRRIDDVNRLVYIADDRAVT
ILQAKYHY

Nucleotide

• Length: 267 bp

>T58211 NZ_CP013298:c28055-27789 [Arthrobacter sp. YC-RL1]
GTGAGTGACAGACTCCTGACCTGGACTACTGGTGGATGGGAAGACTACGTCTGCTGGCAGACCCAGGATCGTAAGACACT
CAAGCGCATTAACTTGCTGATCGAGGACGTGCTCCGTGACGATCCTTTTGAAGGTATCGGAAAGCCTGAACCGTTGAAGC
ATGCATTAGCTGGTGCGTGGTCGCGCCGCATCGATGACGTCAACCGACTGGTGTATATCGCTGATGACCGCGCAGTGACG
ATTCTTCAAGCCAAATACCACTACTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9132.35 Da
• Isoelectric Point: 5.1100

>AT58211 WP_022876888.1 NZ_CP013298:c28300-28052 [Arthrobacter sp. YC-RL1]
MAITTSEARRDLFGLIERVNLDHTEVEIMSKRGSAVLMSKDEYDSLVETSHLLRSPKNAVRLLAALEAARNDQTAEHGLI
EP

Nucleotide

• Length: 249 bp

>AT58211 NZ_CP013298:c28300-28052 [Arthrobacter sp. YC-RL1]
ATGGCAATCACCACCAGCGAAGCGCGACGCGACCTGTTTGGTCTTATCGAACGAGTGAACCTGGACCACACCGAGGTTGA
AATCATGTCCAAGCGTGGGTCCGCAGTGCTCATGTCGAAAGACGAGTATGATTCCCTCGTTGAGACGAGCCACCTGCTGC
GATCGCCTAAGAACGCAGTACGTCTGCTGGCAGCCTTAGAAGCGGCACGCAATGACCAGACTGCAGAACACGGGCTCATC
GAACCGTGA

Structures

Antitoxin

• AlphaFold DB: A0A365Y8H3