Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 3318955..3319607 Replicon chromosome
Accession NZ_CP013290
Organism Janibacter indicus strain YFY001

Toxin (Protein)


Gene name vapC Uniprot ID A0A1L3MKK2
Locus tag ASJ30_RS16160 Protein ID WP_072625981.1
Coordinates 3318955..3319347 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1L3MKI8
Locus tag ASJ30_RS16165 Protein ID WP_072625982.1
Coordinates 3319344..3319607 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASJ30_RS16135 3314815..3315207 - 393 WP_072625978.1 hypothetical protein -
ASJ30_RS16140 3315341..3315955 + 615 WP_072625979.1 hypothetical protein -
ASJ30_RS16145 3316042..3316800 - 759 WP_072626393.1 MerR family transcriptional regulator -
ASJ30_RS16150 3316997..3317428 + 432 WP_072625980.1 hypothetical protein -
ASJ30_RS16155 3317425..3318945 + 1521 WP_072626394.1 multicopper oxidase family protein -
ASJ30_RS16160 3318955..3319347 - 393 WP_072625981.1 type II toxin-antitoxin system VapC family toxin Toxin
ASJ30_RS16165 3319344..3319607 - 264 WP_072625982.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
ASJ30_RS16170 3319874..3320911 + 1038 WP_094078917.1 phytanoyl-CoA dioxygenase family protein -
ASJ30_RS16175 3320921..3321691 + 771 WP_072625984.1 SDR family oxidoreductase -
ASJ30_RS16180 3321693..3322718 + 1026 WP_072625985.1 Gfo/Idh/MocA family oxidoreductase -
ASJ30_RS16185 3322740..3323963 - 1224 WP_083546237.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 3201214..3369203 167989


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(1-86)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14090.95 Da        Isoelectric Point: 4.5860

>T58210 WP_072625981.1 NZ_CP013290:c3319347-3318955 [Janibacter indicus]
VIVDTSVLVCIHDGEPEARRYLEVLLDEPSPRISAGSLLEASIVLDARQPLRTSRRLDRLVADLRLDVVPVDEQQVTAAR
AAYRDYGKGSGHAAGLNFGDCFAYALAATTGEPLLFKGDDFTHTDVLPVV

Download         Length: 393 bp

>T58210 NZ_CP013290:c3319347-3318955 [Janibacter indicus]
GTGATCGTCGATACGTCGGTGCTCGTCTGCATCCACGACGGTGAGCCCGAGGCCCGCCGCTACCTGGAGGTGCTGCTCGA
CGAGCCCTCGCCACGCATCTCCGCCGGGTCGCTCCTCGAGGCCTCGATCGTCCTCGACGCGCGCCAGCCCCTGCGGACCT
CTCGACGCCTCGACCGACTCGTGGCCGACCTGCGCCTCGACGTGGTGCCGGTGGACGAGCAGCAGGTCACCGCTGCGCGA
GCGGCATACCGCGACTACGGCAAGGGGTCCGGGCACGCGGCCGGGCTCAACTTCGGCGACTGCTTCGCCTATGCCCTGGC
CGCCACGACGGGAGAGCCCCTGCTCTTCAAGGGAGACGACTTCACCCACACGGACGTGCTGCCCGTGGTGTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9962.99 Da        Isoelectric Point: 4.7278

>AT58210 WP_072625982.1 NZ_CP013290:c3319607-3319344 [Janibacter indicus]
MGLNIKNQRVHDLAREVAQRTGTTQTSAIEEALQRRLEALRAADDDDARRRRLLRLMDEIESDTTDADRARTAQVQEELY
DDRGLPA

Download         Length: 264 bp

>AT58210 NZ_CP013290:c3319607-3319344 [Janibacter indicus]
ATGGGTCTGAACATCAAGAACCAGCGTGTCCATGACCTCGCGAGGGAGGTCGCGCAGCGCACGGGCACCACGCAGACGAG
CGCGATCGAGGAGGCTCTGCAGCGCAGGCTGGAGGCGCTGCGGGCGGCCGATGACGACGACGCCCGCCGCCGGCGGCTGC
TGCGTCTCATGGACGAGATCGAGTCCGACACGACGGACGCGGACCGTGCCCGGACCGCGCAGGTCCAGGAGGAGCTCTAC
GACGACCGTGGGCTGCCGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1L3MKK2

Antitoxin

Source ID Structure
AlphaFold DB A0A1L3MKI8

References