Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3180412..3181016 Replicon chromosome
Accession NZ_CP013290
Organism Janibacter indicus strain YFY001

Toxin (Protein)


Gene name vapC Uniprot ID A0A7G7HSU6
Locus tag ASJ30_RS15450 Protein ID WP_072625875.1
Coordinates 3180412..3180792 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1L3MKA4
Locus tag ASJ30_RS15455 Protein ID WP_072625876.1
Coordinates 3180789..3181016 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASJ30_RS15420 3176229..3177170 + 942 WP_072625869.1 LysR family transcriptional regulator -
ASJ30_RS15425 3177167..3177916 - 750 WP_083546222.1 DUF998 domain-containing protein -
ASJ30_RS15435 3178077..3179006 - 930 WP_072625872.1 alpha/beta hydrolase -
ASJ30_RS15440 3179099..3179734 + 636 WP_072625873.1 DUF3105 domain-containing protein -
ASJ30_RS15445 3179731..3180360 + 630 WP_072625874.1 DUF305 domain-containing protein -
ASJ30_RS15450 3180412..3180792 - 381 WP_072625875.1 type II toxin-antitoxin system VapC family toxin Toxin
ASJ30_RS15455 3180789..3181016 - 228 WP_072625876.1 antitoxin Antitoxin
ASJ30_RS15460 3181070..3182041 + 972 WP_083546223.1 threonine/serine dehydratase -
ASJ30_RS15465 3182070..3182774 - 705 WP_072625878.1 transporter substrate-binding domain-containing protein -
ASJ30_RS15470 3182827..3183378 - 552 WP_072625879.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(3-125)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13446.48 Da        Isoelectric Point: 4.8616

>T58209 WP_072625875.1 NZ_CP013290:c3180792-3180412 [Janibacter indicus]
VIVVDASAMVEALVGRAPDPRLLDALAGVVEAPQHLDVEVLSVLRGLTLGAKLPAARAEEALGAYLDLDITRRDVAPFAR
RVWSLRHQYTSYDAAYLALAEGLDAPLYTCDRKLAAGGHTAEVVVI

Download         Length: 381 bp

>T58209 NZ_CP013290:c3180792-3180412 [Janibacter indicus]
GTGATCGTCGTCGATGCCTCGGCGATGGTCGAGGCGCTCGTGGGGCGTGCGCCGGACCCGCGACTCCTCGACGCCCTTGC
CGGCGTGGTCGAGGCGCCGCAGCACCTGGACGTCGAGGTGCTGTCCGTCCTGCGGGGCCTGACGCTCGGGGCCAAGCTCC
CGGCGGCACGCGCCGAGGAGGCACTCGGGGCCTATCTCGACCTCGACATCACAAGACGGGACGTGGCTCCCTTCGCCCGG
AGGGTCTGGTCGCTGCGGCACCAGTACACGAGCTACGACGCGGCCTACCTGGCCCTGGCCGAGGGGCTCGACGCGCCGCT
CTACACGTGCGACCGCAAGCTGGCCGCCGGCGGTCACACGGCCGAGGTGGTCGTGATCTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8262.26 Da        Isoelectric Point: 5.0492

>AT58209 WP_072625876.1 NZ_CP013290:c3181016-3180789 [Janibacter indicus]
MPTLYIRDVPDDVAETLKQRAAADGQSLSAYVAGALLRLAERPTNAEVVERLRQVDRTSAPATDEIVSTLHESRR

Download         Length: 228 bp

>AT58209 NZ_CP013290:c3181016-3180789 [Janibacter indicus]
ATGCCCACCCTGTACATCCGTGACGTCCCCGACGACGTGGCCGAGACGCTCAAGCAGCGTGCGGCGGCCGACGGGCAGTC
CCTGTCCGCTTACGTCGCCGGTGCGCTGCTTCGGCTTGCGGAACGCCCCACCAATGCCGAGGTCGTCGAGCGACTGCGGC
AGGTGGACCGGACATCGGCCCCGGCCACCGATGAGATCGTCTCGACGCTGCACGAGAGCCGCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7G7HSU6

Antitoxin

Source ID Structure
AlphaFold DB A0A1L3MKA4

References