Detailed information of TA system TA058208

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 1627850..1628454
• Replicon: chromosome
• Accession: NZ_CP013290
• Organism: Janibacter indicus strain YFY001

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A7G7HX65
• Locus tag: ASJ30_RS07750
• Protein ID: WP_072624583.1
• Coordinates: 1628056..1628454 (+)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: ASJ30_RS07745
• Protein ID: WP_094078827.1
• Coordinates: 1627850..1628059 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ASJ30_RS07725	1623747..1624568	-	822	WP_072626202.1	SDR family oxidoreductase	-
ASJ30_RS07730	1624717..1625742	-	1026	WP_072624581.1	TerC/Alx family metal homeostasis membrane protein	-
ASJ30_RS07735	1625919..1627328	-	1410	WP_083546083.1	FAD-dependent oxidoreductase	-
ASJ30_RS07740	1627500..1627829	+	330	WP_072624582.1	single-stranded DNA-binding protein	-
ASJ30_RS07745	1627850..1628059	+	210	WP_094078827.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
ASJ30_RS07750	1628056..1628454	+	399	WP_072624583.1	PIN domain nuclease	Toxin
ASJ30_RS07760	1628943..1629863	+	921	WP_072624585.1	dihydrodipicolinate synthase family protein	-
ASJ30_RS07765	1629860..1630384	+	525	WP_072624586.1	hypothetical protein	-
ASJ30_RS07770	1630459..1630704	+	246	WP_072624587.1	hypothetical protein	-
ASJ30_RS07775	1630714..1631154	+	441	WP_072624588.1	hypothetical protein	-
ASJ30_RS07780	1631249..1631803	-	555	WP_072624589.1	hypothetical protein	-
ASJ30_RS07785	1631951..1633024	-	1074	WP_072624590.1	FUSC family protein	-
ASJ30_RS07790	1633052..1633438	-	387	WP_072624591.1	VOC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-121)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (3-38)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 14518.57 Da
• Isoelectric Point: 6.9687

>T58208 WP_072624583.1 NZ_CP013290:1628056-1628454 [Janibacter indicus]
VTLVDTSVWVEYLRGTDSPSTRYVRERLGSDLFTTEPVLMELLAGARHGASTARLERLLLSQSWARLKPALDHRGAVDVF
HACRSDGRPIRSINDCLIAAIALRVDIAVAHRDSDFEHIAAVTGLTVVDLRG

Nucleotide

• Length: 399 bp

>T58208 NZ_CP013290:1628056-1628454 [Janibacter indicus]
GTGACGCTCGTCGACACCTCCGTGTGGGTCGAGTACCTGCGCGGCACCGACTCGCCCTCCACCCGATATGTGCGGGAGCG
TCTCGGCAGCGACCTGTTCACCACCGAGCCCGTGCTCATGGAGCTGCTGGCCGGGGCTCGTCATGGGGCGTCGACGGCTC
GCCTCGAGCGGCTGCTCCTCAGCCAGAGCTGGGCGCGCCTGAAGCCCGCGCTCGACCATCGCGGTGCGGTTGACGTCTTC
CACGCCTGCCGTTCCGACGGGCGCCCGATCCGGTCGATCAACGATTGCCTCATCGCTGCCATCGCCTTGCGCGTCGACAT
CGCCGTCGCCCATCGTGACTCCGACTTCGAGCACATCGCAGCGGTCACCGGCCTCACCGTCGTCGACCTGCGCGGCTGA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 7765.81 Da
• Isoelectric Point: 4.1964

>AT58208 WP_094078827.1 NZ_CP013290:1627850-1628059 [Janibacter indicus]
MGRTNIEIDDDLIAEAMRRYGLATKREAVDFALRRLVGPVMTREEMLAMEGSGWDGDLDQVRSDPVEPV

Nucleotide

• Length: 210 bp

>AT58208 NZ_CP013290:1627850-1628059 [Janibacter indicus]
ATGGGGCGCACCAACATCGAGATCGACGACGACCTCATCGCCGAGGCCATGCGTCGCTATGGGCTCGCGACCAAGCGTGA
GGCGGTCGACTTCGCCCTGCGTCGTCTCGTGGGCCCGGTCATGACGCGCGAGGAGATGCTCGCGATGGAGGGCAGTGGCT
GGGACGGCGACCTCGACCAGGTGAGGTCCGACCCGGTGGAGCCGGTGTGA

Structures

Toxin

• AlphaFold DB: A0A7G7HX65