58202

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/Tad-HTH_37
Location 50467..51164 Replicon plasmid pDE3
Accession NZ_CP013267
Organism Sphingobium baderi strain DE-13

Toxin (Protein)


Gene name tad Uniprot ID T0J3S2
Locus tag ATN00_RS22085 Protein ID WP_013041565.1
Coordinates 50790..51164 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID T0G937
Locus tag ATN00_RS22080 Protein ID WP_006964370.1
Coordinates 50467..50793 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ATN00_RS22050 46064..46819 + 756 WP_022675885.1 P-type conjugative transfer protein TrbJ -
ATN00_RS22055 46829..47071 + 243 WP_019053956.1 EexN family lipoprotein -
ATN00_RS22060 47082..48797 + 1716 WP_030092735.1 P-type conjugative transfer protein TrbL -
ATN00_RS22065 48800..49912 + 1113 WP_030092736.1 muramidase -
ATN00_RS22070 49933..50232 - 300 WP_013041567.1 hypothetical protein -
ATN00_RS22075 50225..50467 - 243 WP_013041566.1 hypothetical protein -
ATN00_RS22080 50467..50793 - 327 WP_006964370.1 helix-turn-helix domain-containing protein Antitoxin
ATN00_RS22085 50790..51164 - 375 WP_013041565.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ATN00_RS22090 51586..51840 + 255 WP_013041563.1 hypothetical protein -
ATN00_RS22095 52171..53286 - 1116 WP_030092861.1 IS110 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..73561 73561
- flank IS/Tn - - 53363..56305 2942


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-108)

Antitoxin

HigA2-like, helix-turn-helix domain

(15-94)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13960.67 Da        Isoelectric Point: 9.4885

>T58202 WP_013041565.1 NZ_CP013267:c51164-50790 [Sphingobium baderi]
MDTERPVRWVASSKRDFREFPDDVQDVMGYALHLAQQGGQHASTKPLKGFGGAGVVEIIDDHQGDTFRTVYTVKFAEAVY
VLHAFQKKSKQGKATPQADMDLIRTRLKSAEEHHRQHQTPRGTA

Download         Length: 375 bp

>T58202 NZ_CP013267:c51164-50790 [Sphingobium baderi]
ATGGATACGGAACGGCCGGTTCGATGGGTGGCATCGTCAAAGCGCGATTTTCGGGAGTTCCCGGACGATGTGCAGGACGT
AATGGGCTATGCCCTGCACCTTGCGCAGCAAGGCGGGCAGCACGCCAGCACTAAGCCGTTGAAGGGCTTTGGCGGCGCTG
GCGTGGTCGAGATCATAGACGACCACCAAGGCGATACGTTCCGCACGGTCTATACGGTCAAATTCGCGGAGGCGGTCTAT
GTCCTGCACGCCTTCCAGAAGAAATCCAAGCAGGGCAAGGCCACGCCGCAGGCCGATATGGATTTGATCCGAACGCGGCT
GAAATCCGCCGAGGAGCATCACCGGCAACACCAGACCCCGCGAGGCACAGCATGA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 11792.57 Da        Isoelectric Point: 7.1681

>AT58202 WP_006964370.1 NZ_CP013267:c50793-50467 [Sphingobium baderi]
MSAQDEIIEEGSGNVFADLGFADPDTHLLKAQLVTRVAEAMQERKLTQIAAAKVTGSTQPELSRILRGQFRSVSVERLLA
MLTRLGCKVDIVVRPQGRTTESAVIHFA

Download         Length: 327 bp

>AT58202 NZ_CP013267:c50793-50467 [Sphingobium baderi]
ATGAGCGCACAGGACGAAATCATTGAGGAAGGCAGCGGCAATGTCTTTGCCGATCTAGGCTTTGCCGACCCCGACACCCA
CCTTTTGAAAGCCCAGCTCGTTACCCGTGTGGCCGAGGCCATGCAGGAGCGGAAGTTGACGCAGATCGCCGCCGCCAAGG
TTACGGGATCTACCCAACCGGAATTGTCGCGCATCCTGCGAGGCCAGTTCCGCAGCGTCTCGGTTGAGCGGCTTCTAGCC
ATGCTCACCCGGCTTGGCTGCAAGGTCGATATTGTCGTGCGCCCGCAGGGGCGGACCACTGAATCGGCCGTGATCCACTT
CGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J7XHG4

Antitoxin

Source ID Structure
AlphaFold DB A0A0J8A803

References