58199

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 21126..21603 Replicon plasmid pDE1
Accession NZ_CP013265
Organism Sphingobium baderi strain DE-13

Toxin (Protein)


Gene name pasB Uniprot ID A0A0S3F5L2
Locus tag ATN00_RS20190 Protein ID WP_062069089.1
Coordinates 21337..21603 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID A0A0S3F5D9
Locus tag ATN00_RS20185 Protein ID WP_062069087.1
Coordinates 21126..21353 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ATN00_RS20140 16481..16705 + 225 WP_062069072.1 hypothetical protein -
ATN00_RS20145 16693..16914 + 222 WP_062069074.1 hypothetical protein -
ATN00_RS20150 16990..17562 + 573 WP_062069373.1 hypothetical protein -
ATN00_RS20155 17559..18578 + 1020 WP_062069077.1 hypothetical protein -
ATN00_RS20160 18630..18944 + 315 WP_062069079.1 hypothetical protein -
ATN00_RS20165 19036..19476 + 441 WP_062069081.1 hypothetical protein -
ATN00_RS20170 19564..20235 + 672 WP_062069083.1 hypothetical protein -
ATN00_RS20175 20247..20546 + 300 WP_062069085.1 hypothetical protein -
ATN00_RS23775 20561..21070 + 510 WP_197413759.1 hypothetical protein -
ATN00_RS20185 21126..21353 + 228 WP_062069087.1 ribbon-helix-helix protein, CopG family Antitoxin
ATN00_RS20190 21337..21603 + 267 WP_062069089.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ATN00_RS20195 21681..22187 + 507 WP_062069091.1 hypothetical protein -
ATN00_RS20200 22206..22988 + 783 WP_062069094.1 hypothetical protein -
ATN00_RS20205 22993..24123 + 1131 WP_197413760.1 phosphoadenosine phosphosulfate reductase family protein -
ATN00_RS20210 24146..24433 + 288 WP_062069097.1 hypothetical protein -
ATN00_RS20215 24559..25908 + 1350 WP_021235312.1 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..229716 229716


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10004.54 Da        Isoelectric Point: 10.6086

>T58199 WP_062069089.1 NZ_CP013265:21337-21603 [Sphingobium baderi]
MAWQIELSSNAEKSLSKLDRQTAKRIMTFLRERVASSDDPRASGKPLTGPLAGRWRYRVGDYRIVCEIEDGRLVVLVLTV
GHRSGIYR

Download         Length: 267 bp

>T58199 NZ_CP013265:21337-21603 [Sphingobium baderi]
TTGGCCTGGCAGATTGAACTGTCATCCAACGCCGAAAAATCTCTCTCCAAACTCGATCGCCAGACCGCAAAGCGGATCAT
GACCTTCCTGCGCGAGCGTGTTGCATCCAGTGACGATCCCCGCGCATCTGGAAAGCCATTGACCGGGCCCTTGGCAGGGC
GCTGGCGCTACCGCGTTGGCGACTACCGGATTGTCTGCGAGATCGAGGATGGCAGGCTTGTCGTGCTTGTGCTGACCGTC
GGCCACCGAAGCGGCATTTACCGCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8540.58 Da        Isoelectric Point: 4.4066

>AT58199 WP_062069087.1 NZ_CP013265:21126-21353 [Sphingobium baderi]
MATSVRLAPEVEQRLDHLATTTGRTKAYYLREIIERGLEDMEDIYLSDKVLEDIRAGRETTSSLDDVEKRLGLAD

Download         Length: 228 bp

>AT58199 NZ_CP013265:21126-21353 [Sphingobium baderi]
ATGGCGACGTCAGTACGCCTCGCCCCAGAAGTAGAGCAGCGCCTCGACCATCTCGCGACCACCACCGGGCGCACCAAGGC
CTATTACCTGCGCGAAATCATCGAGCGCGGCCTTGAGGACATGGAAGACATCTACCTCTCCGACAAGGTGCTCGAGGATA
TTCGCGCTGGCCGCGAAACCACAAGCTCCCTTGACGACGTGGAGAAGCGCCTTGGCCTGGCAGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0S3F5L2

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3F5D9

References