58196

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 225496..226526 Replicon chromosome
Accession NZ_CP013264
Organism Sphingobium baderi strain DE-13

Toxin (Protein)


Gene name PP_4152 Uniprot ID A0A0S3EUM1
Locus tag ATN00_RS01165 Protein ID WP_062061072.1
Coordinates 225496..226065 (-) Length 190 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID A0A0J7XHM6
Locus tag ATN00_RS01170 Protein ID WP_030092865.1
Coordinates 226062..226526 (-) Length 155 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ATN00_RS01125 220923..222296 - 1374 WP_062061067.1 DUF2384 domain-containing protein -
ATN00_RS01135 222777..223775 - 999 WP_156415190.1 tyrosine-type recombinase/integrase -
ATN00_RS01140 223736..224107 - 372 WP_030092871.1 hypothetical protein -
ATN00_RS01145 224141..224506 - 366 WP_030092870.1 hypothetical protein -
ATN00_RS01150 224503..224835 - 333 WP_030092869.1 hypothetical protein -
ATN00_RS01155 224866..225096 - 231 WP_030092868.1 BrnA antitoxin family protein -
ATN00_RS22695 225083..225356 - 274 Protein_226 BrnT family toxin -
ATN00_RS01165 225496..226065 - 570 WP_062061072.1 PIN domain-containing protein Toxin
ATN00_RS01170 226062..226526 - 465 WP_030092865.1 helix-turn-helix domain-containing protein Antitoxin
ATN00_RS01175 226721..227029 + 309 WP_062061074.1 BrnT family toxin -
ATN00_RS01180 227010..227342 + 333 WP_062061077.1 BrnA antitoxin family protein -
ATN00_RS01185 227346..227603 + 258 Protein_231 DUF2442 domain-containing protein -
ATN00_RS01190 227632..228351 - 720 WP_062061080.1 hypothetical protein -
ATN00_RS01195 228348..228782 - 435 WP_062061082.1 putative toxin-antitoxin system toxin component, PIN family -
ATN00_RS01200 228786..229031 - 246 WP_197413644.1 ribbon-helix-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - tufA 112541..293149 180608


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-113)

Antitoxin

SinI-like, DNA-binding domain

(81-127)


Sequences

Toxin        


Download         Length: 190 a.a.        Molecular weight: 21125.31 Da        Isoelectric Point: 6.6936

>T58196 WP_062061072.1 NZ_CP013264:c226065-225496 [Sphingobium baderi]
MSHYTALLDANVLYPAPMRDLLMQIAVTDLFKAKWSADIHREWIEALLRNEPHRDRAALERTRDRMDRAMRDALVTGYDT
LIPSLDLPDRGDRHVLAAAIVGRCDVIVTQNLKHFPASSLASYGIEAQHPDEFLTSHLHLAPGVFCSAVAKVRARLTAPP
YTVEEYLAILTRQSLVGTVAELAPFSNLL

Download         Length: 570 bp

>T58196 NZ_CP013264:c226065-225496 [Sphingobium baderi]
ATGAGCCATTATACGGCGCTGCTGGACGCTAACGTCCTCTATCCCGCCCCCATGCGCGATCTGCTGATGCAGATTGCCGT
TACCGATCTGTTCAAGGCCAAATGGAGCGCGGACATTCATCGCGAGTGGATCGAGGCGCTGTTACGCAACGAACCGCACC
GCGACCGAGCCGCGCTGGAACGCACGCGCGACCGCATGGACAGGGCGATGCGCGACGCCCTTGTGACGGGCTATGACACG
CTGATTCCATCTCTTGATTTGCCCGATCGCGGCGACCGGCATGTGCTGGCCGCCGCGATCGTCGGGCGCTGCGACGTGAT
CGTGACGCAGAACCTCAAGCATTTTCCCGCTTCGTCCCTCGCGTCCTATGGCATCGAGGCGCAGCATCCCGACGAATTTC
TGACCAGCCATTTACACCTCGCACCCGGCGTCTTTTGCAGCGCCGTTGCAAAGGTGCGCGCCCGTCTTACCGCGCCGCCC
TATACGGTCGAGGAATATCTCGCGATCCTGACCCGGCAAAGCCTGGTCGGCACCGTCGCCGAGTTGGCGCCATTTTCAAA
CCTTCTCTGA

Antitoxin


Download         Length: 155 a.a.        Molecular weight: 17253.85 Da        Isoelectric Point: 6.4930

>AT58196 WP_030092865.1 NZ_CP013264:c226526-226062 [Sphingobium baderi]
MNMLAHRQMPPTPQDAAIARLSGQVLAGYARQKRPLTLRVRDAEQEKPIELPAGAVSLLMDILDAMAAGRGVTIIPEDAE
LTTVQAADMLNVSRTFLINLLDTGVIPHRKVGTHRRIRMEDLMAYKARDDRDRETVLDELAREAQEQDMGYRHA

Download         Length: 465 bp

>AT58196 NZ_CP013264:c226526-226062 [Sphingobium baderi]
ATGAACATGCTCGCCCATCGCCAGATGCCGCCGACACCGCAGGATGCCGCCATAGCGCGCCTGTCGGGCCAGGTGCTTGC
CGGCTATGCCCGCCAGAAACGCCCGCTGACCTTGCGCGTGCGCGACGCCGAACAGGAGAAGCCCATAGAGCTGCCCGCCG
GCGCGGTGTCGCTGCTCATGGATATTCTCGACGCGATGGCCGCCGGTCGCGGTGTGACGATCATTCCCGAGGATGCGGAG
CTGACCACCGTGCAGGCGGCCGACATGCTCAATGTCTCGCGCACTTTCCTCATCAACCTGCTCGATACCGGCGTGATCCC
GCATCGCAAGGTCGGCACGCACCGCCGTATCCGCATGGAAGATTTGATGGCCTATAAGGCCCGTGACGACCGCGACCGGG
AAACCGTGCTGGATGAACTGGCCCGAGAGGCCCAGGAACAGGACATGGGCTATCGTCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0S3EUM1

Antitoxin

Source ID Structure
AlphaFold DB A0A0J7XHM6

References