Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 219517..220076 Replicon chromosome
Accession NZ_CP013264
Organism Sphingobium baderi strain DE-13

Toxin (Protein)


Gene name parE Uniprot ID A0A0J8A5F8
Locus tag ATN00_RS01110 Protein ID WP_059153568.1
Coordinates 219783..220076 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0S3EUK8
Locus tag ATN00_RS01105 Protein ID WP_062061055.1
Coordinates 219517..219795 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ATN00_RS01085 216384..217004 + 621 WP_008832583.1 recombinase family protein -
ATN00_RS01090 217001..217531 + 531 WP_062061046.1 GNAT family N-acetyltransferase -
ATN00_RS01095 217589..218223 + 635 Protein_214 transposase -
ATN00_RS01100 218566..219126 - 561 WP_062061052.1 recombinase family protein -
ATN00_RS01105 219517..219795 + 279 WP_062061055.1 CopG family ribbon-helix-helix protein Antitoxin
ATN00_RS01110 219783..220076 + 294 WP_059153568.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ATN00_RS23270 220095..220190 + 96 Protein_218 histidine phosphatase family protein -
ATN00_RS22680 220205..220486 - 282 WP_082635049.1 WGR domain-containing protein -
ATN00_RS01125 220923..222296 - 1374 WP_062061067.1 DUF2384 domain-containing protein -
ATN00_RS01135 222777..223775 - 999 WP_156415190.1 tyrosine-type recombinase/integrase -
ATN00_RS01140 223736..224107 - 372 WP_030092871.1 hypothetical protein -
ATN00_RS01145 224141..224506 - 366 WP_030092870.1 hypothetical protein -
ATN00_RS01150 224503..224835 - 333 WP_030092869.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - tufA 112541..293149 180608


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-94)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10942.43 Da        Isoelectric Point: 7.4007

>T58195 WP_059153568.1 NZ_CP013264:219783-220076 [Sphingobium baderi]
VPRLIWTAEALADVDRLHRWLKTKDADAARRAVAAIRGGVRILAATPHIGRPTEDMESEYREKLIDFGNSGYVVLYHFDG
ETVALLAVRHQREAGYQ

Download         Length: 294 bp

>T58195 NZ_CP013264:219783-220076 [Sphingobium baderi]
GTGCCACGTCTGATCTGGACGGCCGAAGCACTGGCCGATGTTGACCGGCTCCATCGCTGGTTGAAGACCAAAGACGCCGA
CGCAGCGAGACGCGCGGTCGCCGCGATCCGGGGAGGGGTTCGGATTCTGGCGGCAACCCCGCACATCGGCCGACCAACTG
AAGATATGGAGTCCGAGTATCGGGAAAAGCTGATCGACTTTGGAAACAGCGGCTATGTTGTCCTGTATCACTTCGATGGT
GAGACGGTGGCGCTGTTGGCCGTGCGCCACCAAAGGGAGGCGGGTTATCAATAG

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10686.02 Da        Isoelectric Point: 6.0877

>AT58195 WP_062061055.1 NZ_CP013264:219517-219795 [Sphingobium baderi]
MATATSIKLDDALKERVQHLANARRRSSHWIMREAIAQYVEREEKREAFKQDAIRAWENYQQTGLHVTLEEADVWLAKLE
AGEDAEPPKCHV

Download         Length: 279 bp

>AT58195 NZ_CP013264:219517-219795 [Sphingobium baderi]
ATGGCAACGGCAACATCTATTAAGCTGGACGATGCCCTGAAAGAGCGTGTGCAGCACCTGGCCAACGCGCGCCGGCGCAG
CTCGCATTGGATTATGCGCGAAGCTATCGCGCAGTATGTCGAGCGCGAGGAAAAGCGCGAGGCATTCAAACAGGACGCCA
TTCGGGCATGGGAAAACTATCAGCAGACGGGCTTGCATGTGACGCTTGAGGAAGCCGATGTCTGGTTGGCGAAGCTCGAA
GCGGGTGAGGATGCGGAGCCGCCTAAGTGCCACGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J8A5F8

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3EUK8

References