Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 1978630..1979189 Replicon chromosome
Accession NZ_CP013248
Organism Vibrio parahaemolyticus strain FORC_022

Toxin (Protein)


Gene name relE Uniprot ID A0A347UR22
Locus tag FORC22_RS09325 Protein ID WP_005398411.1
Coordinates 1978911..1979189 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A347UR21
Locus tag FORC22_RS09320 Protein ID WP_005398409.1
Coordinates 1978630..1978914 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC22_RS27340 1974950..1975096 - 147 WP_195183119.1 DUF3265 domain-containing protein -
FORC22_RS09275 1975071..1975343 - 273 WP_005462157.1 nicotinamide mononucleotide transporter -
FORC22_RS09280 1975370..1975492 - 123 WP_071652165.1 DUF3265 domain-containing protein -
FORC22_RS09285 1975489..1975839 - 351 WP_038152015.1 hypothetical protein -
FORC22_RS09290 1975867..1975956 - 90 WP_071652514.1 DUF3265 domain-containing protein -
FORC22_RS09295 1976078..1976329 - 252 WP_079866443.1 hypothetical protein -
FORC22_RS09300 1976467..1976595 - 129 WP_079866444.1 DUF3265 domain-containing protein -
FORC22_RS09305 1976585..1977337 - 753 WP_069540325.1 DUF4393 domain-containing protein -
FORC22_RS09310 1977474..1978553 - 1080 WP_154036210.1 DUF3265 domain-containing protein -
FORC22_RS09320 1978630..1978914 + 285 WP_005398409.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
FORC22_RS09325 1978911..1979189 + 279 WP_005398411.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
FORC22_RS09330 1979393..1979617 - 225 WP_071652168.1 hypothetical protein -
FORC22_RS09335 1979660..1979752 - 93 WP_071652169.1 DUF3265 domain-containing protein -
FORC22_RS09340 1979767..1980414 - 648 WP_071652170.1 hypothetical protein -
FORC22_RS09345 1980593..1981720 - 1128 WP_071652171.1 hypothetical protein -
FORC22_RS09350 1981858..1982709 - 852 WP_071652172.1 hypothetical protein -
FORC22_RS09355 1982751..1982840 - 90 WP_071652517.1 DUF3265 domain-containing protein -
FORC22_RS09360 1983087..1983347 - 261 WP_071652173.1 hypothetical protein -
FORC22_RS25675 1983360..1983438 - 79 Protein_1790 DUF3265 domain-containing protein -
FORC22_RS09370 1983467..1983964 - 498 WP_021448757.1 DNA topology modulation protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 1975071..2075156 100085


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10891.57 Da        Isoelectric Point: 4.3430

>T58193 WP_005398411.1 NZ_CP013248:1978911-1979189 [Vibrio parahaemolyticus]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVEGDIIRVM
RVLHQKQKFPTD

Download         Length: 279 bp

>T58193 NZ_CP013248:1978911-1979189 [Vibrio parahaemolyticus]
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAAAGATCTTCGAGTTTCTCTATGACTTCAACCCTGATGCGGC
AGAAAAAACTGACAACCTCATTGAAGCAAAAGTAGAAAACTTGCTTGAACAACCTTTAATGGGTGTACAACGAGATGGCA
TCCGCGGACGATTGCTCATTATTCCTGAGATTTCGATGATTGTCTCTTATTGGGTCGAGGGCGATATCATCAGAGTTATG
CGTGTACTCCACCAGAAACAAAAATTCCCTACGGATTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 11069.40 Da        Isoelectric Point: 9.2167

>AT58193 WP_005398409.1 NZ_CP013248:1978630-1978914 [Vibrio parahaemolyticus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNRGKQ

Download         Length: 285 bp

>AT58193 NZ_CP013248:1978630-1978914 [Vibrio parahaemolyticus]
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGGCTAGCTCAACAAATGGCTGAGAGCCAAGGTCGCAC
TCTGAGTGACGCATGTCGTGAACTTACTGAGCAACTCGCTGAACAACAAAGAAAAACATTATCTCACGATGCATGGCTAA
CTGAACAAGTAAACCTAGCATTTGAGAAGTTTGACTCAGGAAAATCTGTTTTCGTTGAGCACCAAACTGCTAAGTCTCGA
ATGGAAGAGCGCAAAGCCAGAATCCGTAATCGAGGTAAGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A347UR22

Antitoxin

Source ID Structure
AlphaFold DB A0A347UR21

References