Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3502435..3503075 Replicon chromosome
Accession NZ_CP013245
Organism Pseudomonas aeruginosa strain VA-134

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag ATC05_RS16135 Protein ID WP_003134109.1
Coordinates 3502665..3503075 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag ATC05_RS16130 Protein ID WP_031634724.1
Coordinates 3502435..3502665 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ATC05_RS16120 3499480..3500232 - 753 WP_023103392.1 hypothetical protein -
ATC05_RS16125 3500240..3502159 - 1920 WP_023103391.1 type I DNA topoisomerase -
ATC05_RS16130 3502435..3502665 + 231 WP_031634724.1 antitoxin Antitoxin
ATC05_RS16135 3502665..3503075 + 411 WP_003134109.1 tRNA(fMet)-specific endonuclease VapC Toxin
ATC05_RS16140 3503091..3503285 + 195 WP_023103390.1 hypothetical protein -
ATC05_RS30375 3503587..3503763 - 177 WP_126546597.1 CrpP family protein -
ATC05_RS16150 3503975..3504463 - 489 WP_023103388.1 single-stranded DNA-binding protein -
ATC05_RS16155 3504477..3505010 - 534 WP_023103387.1 DUF3158 family protein -
ATC05_RS16160 3505016..3505744 - 729 WP_023103386.1 TIGR03761 family integrating conjugative element protein -
ATC05_RS30380 3505737..3506156 - 420 WP_140419861.1 hypothetical protein -
ATC05_RS16170 3506185..3506424 - 240 WP_003149503.1 hypothetical protein -
ATC05_RS29830 3506415..3506660 - 246 WP_023103385.1 hypothetical protein -
ATC05_RS16175 3506657..3507982 - 1326 WP_023103384.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 3408411..3521196 112785


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin

SpoVT-AbrB domain

(7-33)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15452.78 Da        Isoelectric Point: 7.3233

>T58190 WP_003134109.1 NZ_CP013245:3502665-3503075 [Pseudomonas aeruginosa]
MLKFMLDTNICIFTIKNRPQEVREAFLRHHDQMCISTVTLMELIYGAEKSSNPSRNLADVEGFAARLEVLKYDQEAAAHT
GQLRAELARLGKQIGPYDQMIAGHARSQGLIVVTNNRREFDRVPGLRVEDWVTPIV

Download         Length: 411 bp

>T58190 NZ_CP013245:3502665-3503075 [Pseudomonas aeruginosa]
ATGCTCAAGTTCATGCTTGACACCAACATCTGCATCTTCACCATCAAAAACCGTCCGCAAGAGGTGCGCGAGGCGTTCCT
GCGCCACCACGACCAGATGTGCATCAGCACCGTGACGCTGATGGAGCTGATCTACGGCGCAGAGAAGTCCTCGAACCCCT
CGCGCAATCTTGCAGACGTGGAAGGCTTCGCTGCTCGTCTGGAGGTGCTCAAGTACGACCAGGAAGCTGCCGCCCACACC
GGCCAGCTCCGCGCTGAACTGGCCCGCCTCGGCAAGCAAATCGGCCCCTATGACCAGATGATCGCCGGGCACGCCCGCTC
TCAGGGCCTGATCGTGGTCACCAATAACCGCCGCGAGTTCGACCGCGTACCCGGCTTGAGAGTTGAGGATTGGGTCACCC
CAATCGTATAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8420.29 Da        Isoelectric Point: 4.2821

>AT58190 WP_031634724.1 NZ_CP013245:3502435-3502665 [Pseudomonas aeruginosa]
VEQGSVFQSNRSQAVRLPKAVALPDDVKRVDVVAVGRARIITPAGESWDSWFDGEGVTADFMAEREQPADQERETF

Download         Length: 231 bp

>AT58190 NZ_CP013245:3502435-3502665 [Pseudomonas aeruginosa]
GTGGAACAAGGTTCTGTTTTTCAGAGCAATCGTAGCCAGGCCGTAAGACTGCCCAAGGCCGTCGCGCTTCCTGATGACGT
TAAGCGTGTGGATGTGGTCGCTGTGGGGCGCGCCAGAATCATCACGCCTGCCGGTGAGTCTTGGGATAGCTGGTTCGATG
GCGAGGGCGTTACTGCCGACTTTATGGCTGAGCGTGAACAGCCTGCCGATCAGGAGCGCGAGACTTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References