Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 2070547..2071052 Replicon chromosome
Accession NZ_CP013245
Organism Pseudomonas aeruginosa strain VA-134

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag ATC05_RS09675 Protein ID WP_003083773.1
Coordinates 2070771..2071052 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag ATC05_RS09670 Protein ID WP_003083775.1
Coordinates 2070547..2070774 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ATC05_RS09645 2065565..2067058 + 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -
ATC05_RS09650 2067227..2068654 + 1428 WP_003083784.1 GABA permease -
ATC05_RS09655 2068736..2069077 - 342 WP_003101229.1 alkylphosphonate utilization protein -
ATC05_RS09660 2069150..2069650 - 501 WP_003101228.1 LEA type 2 family protein -
ATC05_RS09665 2069751..2070371 + 621 WP_003101226.1 hypothetical protein -
ATC05_RS09670 2070547..2070774 + 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
ATC05_RS09675 2070771..2071052 + 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
ATC05_RS09680 2071352..2072260 + 909 WP_003083769.1 LysR family transcriptional regulator -
ATC05_RS09685 2072292..2072678 - 387 WP_014602345.1 aegerolysin family protein -
ATC05_RS09690 2072882..2073616 - 735 WP_003115036.1 GntR family transcriptional regulator -
ATC05_RS09695 2073717..2074403 - 687 WP_003083762.1 FadR family transcriptional regulator -
ATC05_RS09700 2074452..2075801 - 1350 WP_003119513.1 C4-dicarboxylate transporter DctA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T58188 WP_003083773.1 NZ_CP013245:2070771-2071052 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T58188 NZ_CP013245:2070771-2071052 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT58188 WP_003083775.1 NZ_CP013245:2070547-2070774 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT58188 NZ_CP013245:2070547-2070774 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References