Detailed information of TA system TA058186

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumA-relB/upstrm_HI1419-DUF971
• Location: 3420858..3421480
• Replicon: chromosome
• Accession: NZ_CP013244
• Organism: Candidatus Viadribacter manganicus strain A272

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: -
• Locus tag: ATE48_RS17490
• Protein ID: WP_228126687.1
• Coordinates: 3421142..3421480 (-)
• Length: 113 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1B1ANK0
• Locus tag: ATE48_RS17485
• Protein ID: WP_066775334.1
• Coordinates: 3420858..3421145 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ATE48_RS17480 (ATE48_17455)	3417880..3419883	-	2004	WP_066773818.1	tetratricopeptide repeat protein	-
ATE48_RS17485 (ATE48_17460)	3420858..3421145	-	288	WP_066775334.1	putative addiction module antidote protein	Antitoxin
ATE48_RS17490 (ATE48_17465)	3421142..3421480	-	339	WP_228126687.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ATE48_RS17495 (ATE48_17470)	3421519..3422163	-	645	WP_228126688.1	tyrosine-type recombinase/integrase	-
ATE48_RS17500 (ATE48_17475)	3422319..3422702	+	384	WP_156767845.1	SMI1/KNR4 family protein	-
ATE48_RS17505 (ATE48_17480)	3422840..3424342	-	1503	WP_083197447.1	MmgE/PrpD family protein	-
ATE48_RS17510 (ATE48_17485)	3424537..3425427	+	891	WP_066773821.1	VOC family protein	-
ATE48_RS17515 (ATE48_17490)	3425420..3425983	+	564	WP_083197448.1	flavin reductase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (14-107)

Antitoxin

• Resolvase, HTH domain (33-70)

Sequences

Toxin

Protein

• Length: 113 a.a.
• Molecular weight: 12542.44 Da
• Isoelectric Point: 9.6806

>T58186 WP_228126687.1 NZ_CP013244:c3421480-3421142 [Candidatus Viadribacter manganicus]
MTIVANKLHCCIPTIIKSDAFAEWIDNLRDRAGAAQVLHRLARLERGNPGIVAPVGEGVSELKIDFGPGYRVYFGQRGQE
LVIILAGGDKSSQERDIKAAKRLWDEWKKQNR

Nucleotide

• Length: 339 bp

>T58186 NZ_CP013244:c3421480-3421142 [Candidatus Viadribacter manganicus]
TTGACAATTGTAGCCAATAAGCTACATTGCTGCATACCGACGATTATCAAGTCCGACGCGTTCGCGGAGTGGATCGATAA
CCTTCGCGACCGCGCCGGCGCCGCCCAGGTGTTGCATCGCCTCGCTCGTTTGGAGCGCGGCAATCCCGGCATTGTTGCGC
CCGTTGGCGAGGGCGTGAGCGAGCTGAAGATCGATTTCGGGCCGGGGTATCGCGTTTATTTTGGGCAACGCGGCCAAGAA
TTGGTGATCATTCTCGCCGGCGGCGACAAGTCCAGCCAAGAGCGGGACATCAAAGCGGCCAAGAGACTGTGGGACGAATG
GAAGAAGCAAAACCGATGA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 9973.35 Da
• Isoelectric Point: 5.0481

>AT58186 WP_066775334.1 NZ_CP013244:c3421145-3420858 [Candidatus Viadribacter manganicus]
MRKAKFSAFDVADHIKTPDDAAHYLDAVLADGDANEIAEALGMVARSQGMAAIAEESGLSRETLYRTLSDAGNPRLATLL
GVLRAMGLRLSVAAA

Nucleotide

• Length: 288 bp

>AT58186 NZ_CP013244:c3421145-3420858 [Candidatus Viadribacter manganicus]
ATGAGGAAAGCTAAGTTCTCGGCCTTCGACGTGGCCGACCATATCAAGACCCCAGACGATGCGGCGCACTATCTCGACGC
CGTACTGGCGGATGGCGATGCGAACGAAATCGCCGAAGCGCTTGGCATGGTCGCCCGCTCCCAAGGCATGGCAGCGATTG
CTGAGGAAAGCGGGCTTTCGCGCGAGACGCTTTATCGAACCCTCAGCGACGCTGGAAATCCGAGACTGGCGACGCTGCTC
GGCGTCCTGCGCGCCATGGGCCTTCGTCTTTCGGTCGCGGCAGCTTAG

Structures

Antitoxin

• AlphaFold DB: A0A1B1ANK0