58185

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) SmuAT/-
Location 1437275..1438236 Replicon chromosome
Accession NZ_CP013237
Organism Streptococcus mutans strain NG8 isolate Dental Plaque

Toxin (Protein)


Gene name smuT Uniprot ID -
Locus tag APQ13_RS06940 Protein ID WP_002264864.1
Coordinates 1437721..1438236 (-) Length 172 a.a.

Antitoxin (Protein)


Gene name smuA Uniprot ID -
Locus tag APQ13_RS06935 Protein ID WP_002289426.1
Coordinates 1437275..1437721 (-) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
APQ13_RS10220 1433400..1433768 - 369 Protein_1349 transposase family protein -
APQ13_RS06905 1433933..1434724 + 792 WP_002289431.1 nucleotidyltransferase domain-containing protein -
APQ13_RS06910 1434929..1435261 - 333 WP_002289429.1 type II toxin-antitoxin system PemK/MazF family toxin -
APQ13_RS06915 1435255..1435500 - 246 WP_002262990.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
APQ13_RS06920 1435822..1436214 - 393 WP_002262992.1 30S ribosomal protein S9 -
APQ13_RS06925 1436239..1436685 - 447 WP_002262993.1 50S ribosomal protein L13 -
APQ13_RS06930 1437084..1437278 - 195 WP_002262994.1 helix-turn-helix transcriptional regulator -
APQ13_RS06935 1437275..1437721 - 447 WP_002289426.1 hypothetical protein Antitoxin
APQ13_RS06940 1437721..1438236 - 516 WP_002264864.1 hypothetical protein Toxin
APQ13_RS06945 1438368..1439228 - 861 WP_002265709.1 DegV family protein -
APQ13_RS06950 1439252..1439998 - 747 WP_002264862.1 23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB -
APQ13_RS06955 1440311..1440865 + 555 WP_002289424.1 PadR family transcriptional regulator -
APQ13_RS06960 1441054..1442046 + 993 WP_002284724.1 BtrH N-terminal domain-containing protein -
APQ13_RS06965 1442082..1442819 - 738 WP_002263001.1 MerR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1433640..1433768 128


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-143)

Antitoxin

Vibrio phage ICP1, Orf50

(10-86)


Sequences

Toxin        


Download         Length: 172 a.a.        Molecular weight: 19540.17 Da        Isoelectric Point: 9.8779

>T58185 WP_002264864.1 NZ_CP013237:c1438236-1437721 [Streptococcus mutans]
MFDLVVNLILLVIVIGGFVFLRFYADKKGKREYDERQLLMQKKAYTNAAWVVMGFNLVLVIWGEVLAKYISLSFAGTANL
FLIVGVFVCSSILNDAYFTARKNKRFLYVYAVIIAIQIFTVYQNWSQGSFGHDGHIYLTGEKAMSLLFILTFAVIFLVTA
YKTIQDKREGK

Download         Length: 516 bp

>T58185 NZ_CP013237:c1438236-1437721 [Streptococcus mutans]
ATGTTTGACCTTGTTGTTAATTTGATTTTATTGGTTATTGTGATAGGTGGATTTGTCTTCTTAAGATTCTATGCGGATAA
GAAAGGCAAGCGAGAATACGATGAACGCCAGTTACTTATGCAAAAGAAAGCTTATACCAATGCGGCTTGGGTTGTTATGG
GTTTCAATCTTGTTCTTGTGATATGGGGTGAAGTGTTAGCAAAATATATCTCGCTATCCTTTGCAGGTACTGCCAATCTC
TTTCTTATCGTAGGGGTCTTTGTCTGCAGCAGTATCTTAAACGATGCTTATTTCACAGCAAGAAAAAACAAAAGATTCCT
CTATGTGTATGCCGTTATTATTGCTATTCAAATTTTCACTGTTTATCAAAATTGGAGTCAAGGCAGCTTTGGTCATGACG
GACATATTTATCTAACAGGAGAAAAAGCAATGAGTTTATTGTTTATCTTGACTTTTGCTGTCATTTTTCTAGTAACTGCT
TATAAGACGATTCAGGATAAGAGAGAGGGAAAGTGA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 17024.34 Da        Isoelectric Point: 9.7659

>AT58185 WP_002289426.1 NZ_CP013237:c1437721-1437275 [Streptococcus mutans]
MKMEKSNKQVIYDERQQQIRLKSYSLSFWFVMFILYFATFGKTDLLLNIAFWGGLVLNFCYSTLRGVGPFVDPRFGKIAK
IGRLAAVPLIFLGMLVFLVAIIMSILEHDSLRESIIKCSYLGLSGFWLICMGASVVYRHYLDKKEADK

Download         Length: 447 bp

>AT58185 NZ_CP013237:c1437721-1437275 [Streptococcus mutans]
ATGAAAATGGAAAAGTCAAATAAACAAGTCATTTACGATGAACGTCAGCAGCAAATTCGACTTAAAAGTTATAGTCTTTC
ATTTTGGTTTGTTATGTTTATACTCTATTTTGCAACCTTTGGAAAGACTGATTTGTTGCTTAATATCGCTTTTTGGGGAG
GACTTGTTCTTAATTTTTGCTACAGTACTCTAAGAGGTGTCGGTCCTTTTGTTGATCCACGTTTTGGAAAAATTGCAAAA
ATCGGTCGTTTGGCCGCTGTTCCCCTTATTTTTTTGGGAATGCTAGTCTTTCTTGTTGCTATCATAATGTCTATTCTAGA
ACATGATAGTTTAAGAGAATCTATCATAAAATGCTCCTACTTAGGCTTATCTGGTTTTTGGCTAATTTGTATGGGAGCAA
GTGTCGTCTACCGTCATTATCTTGATAAGAAAGAAGCAGACAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References