Detailed information of TA system TA058184

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PRK09907-MazE
• Location: 1434929..1435500
• Replicon: chromosome
• Accession: NZ_CP013237
• Organism: Streptococcus mutans strain NG8 isolate Dental Plaque

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: APQ13_RS06910
• Protein ID: WP_002289429.1
• Coordinates: 1434929..1435261 (-)
• Length: 111 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: Q8DW96
• Locus tag: APQ13_RS06915
• Protein ID: WP_002262990.1
• Coordinates: 1435255..1435500 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
APQ13_RS06890	1430443..1431045	-	603	WP_002289786.1	NAD(P)H-dependent oxidoreductase	-
APQ13_RS06895	1431187..1432035	-	849	WP_002265112.1	alpha/beta hydrolase	-
APQ13_RS06900	1432013..1433233	-	1221	WP_002270688.1	PTS sugar transporter subunit IIC	-
APQ13_RS10220	1433400..1433768	-	369	Protein_1349	transposase family protein	-
APQ13_RS06905	1433933..1434724	+	792	WP_002289431.1	nucleotidyltransferase domain-containing protein	-
APQ13_RS06910	1434929..1435261	-	333	WP_002289429.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
APQ13_RS06915	1435255..1435500	-	246	WP_002262990.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
APQ13_RS06920	1435822..1436214	-	393	WP_002262992.1	30S ribosomal protein S9	-
APQ13_RS06925	1436239..1436685	-	447	WP_002262993.1	50S ribosomal protein L13	-
APQ13_RS06930	1437084..1437278	-	195	WP_002262994.1	helix-turn-helix transcriptional regulator	-
APQ13_RS06935	1437275..1437721	-	447	WP_002289426.1	hypothetical protein	-
APQ13_RS06940	1437721..1438236	-	516	WP_002264864.1	hypothetical protein	-
APQ13_RS06945	1438368..1439228	-	861	WP_002265709.1	DegV family protein	-
APQ13_RS06950	1439252..1439998	-	747	WP_002264862.1	23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1433640..1433768	128

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (5-107)

Antitoxin

• SpoVT-AbrB domain (7-50)

Sequences

Toxin

Protein

• Length: 111 a.a.
• Molecular weight: 12650.53 Da
• Isoelectric Point: 6.4634

>T58184 WP_002289429.1 NZ_CP013237:c1435261-1434929 [Streptococcus mutans]
MVTIKQGSVIKINLDPKQGHEQKGYRPYICLNHSIVTKYSNIAIFAPISNTKRDYPFYVPLEGTESTGKVLLDQLVTIDF
NARDYRYVEDIQEDLLDELLARVKVLFEKG

Nucleotide

• Length: 333 bp

>T58184 NZ_CP013237:c1435261-1434929 [Streptococcus mutans]
ATGGTAACCATCAAGCAAGGGTCAGTTATCAAAATTAACTTGGATCCCAAACAAGGACATGAACAAAAAGGGTATCGTCC
GTACATTTGTCTAAACCATAGTATCGTAACCAAGTATTCTAATATTGCTATTTTTGCGCCAATTAGCAATACCAAGCGTG
ATTACCCTTTTTATGTTCCCCTAGAAGGAACAGAATCCACAGGGAAAGTATTATTAGACCAACTGGTTACAATCGATTTT
AATGCTAGAGATTATCGTTATGTGGAGGATATTCAGGAAGACTTATTAGATGAGCTTTTAGCTAGGGTCAAGGTGCTATT
TGAAAAAGGATAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9241.52 Da
• Isoelectric Point: 4.3021

>AT58184 WP_002262990.1 NZ_CP013237:c1435500-1435255 [Streptococcus mutans]
MQLVINKWGNSSAIRLPKQLVQELQLQTNDVLDYKVSGNKIILEKVNNIPELTVEDLFKDYQGEPVNVTPALFESVGNEQ
W

Nucleotide

• Length: 246 bp

>AT58184 NZ_CP013237:c1435500-1435255 [Streptococcus mutans]
ATGCAACTAGTCATCAATAAATGGGGAAATAGCTCCGCTATTCGTTTGCCAAAACAATTGGTACAAGAATTACAATTACA
AACAAATGATGTCTTAGACTATAAGGTATCAGGGAATAAAATTATCCTAGAAAAAGTGAATAATATCCCTGAATTAACTG
TAGAAGATCTGTTTAAAGATTATCAAGGTGAACCTGTCAATGTTACCCCAGCTCTATTTGAAAGTGTGGGAAATGAACAA
TGGTAA

Structures

Antitoxin

• AlphaFold DB: Q8DW96