Detailed information of TA system TA058183

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 291446..292032
• Replicon: chromosome
• Accession: NZ_CP013237
• Organism: Streptococcus mutans strain NG8 isolate Dental Plaque

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: APQ13_RS01455
• Protein ID: WP_002289644.1
• Coordinates: 291446..291637 (+)
• Length: 64 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A0A8KA30
• Locus tag: APQ13_RS01460
• Protein ID: WP_002265422.1
• Coordinates: 291655..292032 (+)
• Length: 126 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
APQ13_RS01440	289490..290356	+	867	WP_002277049.1	type II CRISPR-associated endonuclease Cas1	-
APQ13_RS01445	290353..290697	+	345	WP_002263547.1	CRISPR-associated endonuclease Cas2	-
APQ13_RS01450	290687..291349	+	663	WP_002289642.1	type II-A CRISPR-associated protein Csn2	-
APQ13_RS01455	291446..291637	+	192	WP_002289644.1	type II toxin-antitoxin system HicA family toxin	Toxin
APQ13_RS01460	291655..292032	+	378	WP_002265422.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
APQ13_RS01465	292635..293528	-	894	WP_002270555.1	XRE family transcriptional regulator	-
APQ13_RS01470	293852..294136	+	285	WP_002262720.1	helix-turn-helix transcriptional regulator	-
APQ13_RS01475	294299..296050	+	1752	WP_002289758.1	LPXTG cell wall anchor domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-61)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (5-107)

Sequences

Toxin

Protein

• Length: 64 a.a.
• Molecular weight: 7161.56 Da
• Isoelectric Point: 10.6223

>T58183 WP_002289644.1 NZ_CP013237:291446-291637 [Streptococcus mutans]
MPLIGKELAKLAINNGWEEVRVRGSHHHFKKDGVPYIVTIPIHGNKVLKIGLEKKLLRDLNLL

Nucleotide

• Length: 192 bp

>T58183 NZ_CP013237:291446-291637 [Streptococcus mutans]
TTGCCATTAATAGGGAAAGAATTAGCTAAATTAGCGATAAACAATGGATGGGAAGAAGTTCGGGTGAGAGGAAGTCATCA
TCATTTCAAGAAAGATGGAGTACCTTATATTGTGACGATTCCCATTCATGGAAATAAAGTGCTTAAAATTGGTCTTGAAA
AGAAACTCTTAAGGGATTTAAATTTATTATGA

Antitoxin

Protein

• Length: 126 a.a.
• Molecular weight: 14335.32 Da
• Isoelectric Point: 4.5628

>AT58183 WP_002265422.1 NZ_CP013237:291655-292032 [Streptococcus mutans]
MLKTYPAIFHKEEEGYWVEFPEFGGGTQGEDLEEAMKNARQMLESVLASYLDEGMKLPNPSEIRKLSVEDGFATMIQADP
NPYLKNNKAIRKNVTVPEWLVQLADRDQVNYSEVLTKALERKLQL

Nucleotide

• Length: 378 bp

>AT58183 NZ_CP013237:291655-292032 [Streptococcus mutans]
ATGTTAAAAACATATCCTGCAATTTTTCATAAGGAAGAGGAAGGATATTGGGTTGAATTTCCTGAATTTGGCGGTGGTAC
GCAAGGGGAAGATTTGGAAGAAGCCATGAAGAACGCTCGTCAGATGTTAGAAAGCGTATTGGCCTCCTATCTAGATGAGG
GAATGAAACTGCCTAATCCAAGTGAGATAAGGAAACTATCTGTTGAAGATGGCTTTGCAACTATGATTCAAGCAGATCCT
AATCCTTATCTCAAAAATAACAAAGCTATTCGAAAGAATGTTACCGTACCTGAGTGGCTAGTACAATTAGCAGATCGTGA
TCAAGTGAATTATTCTGAAGTATTAACAAAAGCTTTGGAAAGGAAACTACAATTATAA

Structures

Antitoxin

• AlphaFold DB: A0A0A8KA30