Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1343701..1344275 Replicon chromosome
Accession NZ_CP013236
Organism Collimonas pratensis strain Ter291

Toxin (Protein)


Gene name hicA Uniprot ID A0A127QV12
Locus tag CPter291_RS06080 Protein ID WP_062112826.1
Coordinates 1344093..1344275 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A127QUF8
Locus tag CPter291_RS06075 Protein ID WP_062112823.1
Coordinates 1343701..1344084 (-) Length 128 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CPter291_RS06055 1338914..1340278 + 1365 WP_062112810.1 MFS transporter -
CPter291_RS06060 1340304..1341614 + 1311 WP_062112813.1 homogentisate 1,2-dioxygenase -
CPter291_RS06065 1341628..1342896 + 1269 WP_062112817.1 fumarylacetoacetase -
CPter291_RS06070 1343247..1343666 + 420 WP_062112820.1 antitoxin -
CPter291_RS06075 1343701..1344084 - 384 WP_062112823.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
CPter291_RS06080 1344093..1344275 - 183 WP_062112826.1 type II toxin-antitoxin system HicA family toxin Toxin
CPter291_RS06085 1344544..1345227 - 684 WP_062112829.1 DJ-1/PfpI family protein -
CPter291_RS06090 1345325..1346287 + 963 WP_062112833.1 helix-turn-helix domain-containing protein -
CPter291_RS06095 1346353..1347417 - 1065 WP_062112836.1 purine nucleoside permease -
CPter291_RS06100 1347569..1348471 - 903 WP_061938231.1 lipid A hydroxylase LpxO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1333625..1354980 21355


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-121)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6634.72 Da        Isoelectric Point: 11.0240

>T58176 WP_062112826.1 NZ_CP013236:c1344275-1344093 [Collimonas pratensis]
MNSADIVKQLKAAGWRHVSTRGSHHKYRHPVSGKSVIVPHPKKDLPLGTAESILKQAELK

Download         Length: 183 bp

>T58176 NZ_CP013236:c1344275-1344093 [Collimonas pratensis]
ATGAACAGCGCCGACATTGTCAAGCAACTGAAGGCCGCCGGATGGAGGCACGTCTCTACGCGAGGCAGCCACCACAAATA
TCGCCATCCTGTCAGCGGAAAATCAGTGATTGTCCCGCATCCGAAAAAGGATCTGCCGCTTGGCACGGCCGAGAGCATCT
TGAAACAGGCCGAACTGAAGTGA

Antitoxin


Download         Length: 128 a.a.        Molecular weight: 14133.10 Da        Isoelectric Point: 5.7298

>AT58176 WP_062112823.1 NZ_CP013236:c1344084-1343701 [Collimonas pratensis]
MLYPLYVWKDKNSAYGASFPDLPGVFTAADELNALPAKAQEAAATMYEGETHIPEATSIEKWKDAADYADGYWMLVNIDR
SRINTKPVRLNISLPENLLREIDAFAKAHQLTRSGFLAQAALKAMAR

Download         Length: 384 bp

>AT58176 NZ_CP013236:c1344084-1343701 [Collimonas pratensis]
ATGTTATATCCGCTGTATGTATGGAAGGACAAGAATAGCGCCTACGGCGCAAGCTTTCCGGATCTTCCCGGCGTGTTTAC
TGCCGCAGACGAATTGAACGCCCTGCCGGCAAAAGCCCAGGAAGCAGCAGCAACCATGTACGAGGGCGAGACACATATTC
CCGAAGCGACATCGATCGAAAAATGGAAAGACGCAGCAGACTATGCCGATGGTTACTGGATGCTGGTGAATATTGACCGT
TCCAGAATCAATACAAAACCTGTGCGGCTCAACATTTCATTACCTGAAAATCTGCTGCGCGAAATTGACGCCTTCGCCAA
AGCCCATCAGCTGACGCGTTCCGGCTTCCTGGCTCAGGCTGCGTTGAAGGCGATGGCTCGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A127QV12

Antitoxin

Source ID Structure
AlphaFold DB A0A127QUF8

References