Detailed information of TA system TA058173

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 1314816..1315483
• Replicon: chromosome
• Accession: NZ_CP013236
• Organism: Collimonas pratensis strain Ter291

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A127Q0Q6
• Locus tag: CPter291_RS05900
• Protein ID: WP_061938144.1
• Coordinates: 1315067..1315483 (+)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: CPter291_RS05895
• Protein ID: WP_061938141.1
• Coordinates: 1314816..1315070 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CPter291_RS05870	1310135..1310959	+	825	WP_062112749.1	carbon-nitrogen hydrolase family protein	-
CPter291_RS05875	1311118..1312578	+	1461	WP_062112752.1	metalloprotease TldD	-
CPter291_RS05880	1312598..1313065	+	468	WP_062112754.1	GNAT family N-acetyltransferase	-
CPter291_RS05885	1313122..1313493	-	372	WP_062120435.1	glyoxalase	-
CPter291_RS05890	1313695..1314717	+	1023	WP_062112757.1	cupin-like domain-containing protein	-
CPter291_RS05895	1314816..1315070	+	255	WP_061938141.1	hypothetical protein	Antitoxin
CPter291_RS05900	1315067..1315483	+	417	WP_061938144.1	type II toxin-antitoxin system VapC family toxin	Toxin
CPter291_RS05905	1315549..1315920	+	372	WP_061938147.1	cupin domain-containing protein	-
CPter291_RS05910	1315937..1316224	-	288	WP_062120438.1	metal-binding protein	-
CPter291_RS05915	1316233..1317312	-	1080	WP_062112760.1	bifunctional DNA-binding transcriptional regulator/O6-methylguanine-DNA methyltransferase Ada	-
CPter291_RS05920	1317392..1318060	-	669	WP_061938153.1	DNA-3-methyladenine glycosylase	-
CPter291_RS05925	1318060..1318713	-	654	WP_062112762.1	DNA oxidative demethylase AlkB	-
CPter291_RS05930	1318723..1319463	-	741	WP_062112765.1	2OG-Fe(II) oxygenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-123)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 14768.92 Da
• Isoelectric Point: 5.1224

>T58173 WP_061938144.1 NZ_CP013236:1315067-1315483 [Collimonas pratensis]
MIVLDTNVVSEAMKPEPHSAVRAWLNDQAAETLYLSSVTLAELLFGIGALPAGKRKDMLAQALDELGRLFRDRVLPFDSD
AAQHYADLAVKARAAGRGFPMPDGYIAAIAVSRGFIVASRDTAPFDAAGVSVINPWQA

Nucleotide

• Length: 417 bp

>T58173 NZ_CP013236:1315067-1315483 [Collimonas pratensis]
ATGATTGTTCTCGATACCAATGTTGTTTCCGAGGCGATGAAACCGGAGCCGCATTCCGCCGTGCGGGCATGGCTGAACGA
TCAAGCCGCTGAAACGCTGTATCTGTCCAGCGTGACGCTGGCAGAGCTGCTGTTTGGCATCGGCGCGCTCCCTGCGGGCA
AGCGCAAAGACATGTTGGCACAGGCCCTTGACGAACTGGGGCGACTATTCAGGGATCGCGTGCTGCCATTCGACAGCGAT
GCAGCACAGCACTATGCTGACCTGGCCGTGAAGGCCAGGGCCGCCGGGCGAGGATTCCCGATGCCTGACGGTTACATAGC
TGCGATTGCAGTTTCGCGGGGATTCATCGTGGCATCACGCGACACGGCGCCTTTTGACGCCGCTGGCGTCAGCGTCATCA
ATCCTTGGCAGGCGTAG

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9309.76 Da
• Isoelectric Point: 5.7152

>AT58173 WP_061938141.1 NZ_CP013236:1314816-1315070 [Collimonas pratensis]
MAMLTVRNLPDEVHRALRVRAAQHGRSTEAEVREILAIAVKPETRVLIGEALAALGQKIGLTNEDVEVLEQLTEKTPAQP
LRFE

Nucleotide

• Length: 255 bp

>AT58173 NZ_CP013236:1314816-1315070 [Collimonas pratensis]
ATGGCAATGTTGACAGTACGCAATTTGCCCGACGAGGTGCATCGCGCACTGCGGGTACGGGCCGCTCAACATGGGCGCAG
CACCGAGGCCGAAGTCCGCGAGATTCTGGCGATCGCAGTCAAACCAGAGACCCGAGTTCTGATTGGTGAAGCCCTGGCGG
CATTGGGCCAGAAGATCGGTCTCACGAATGAGGATGTCGAGGTTCTCGAACAATTGACAGAGAAGACTCCGGCCCAGCCG
TTGAGGTTTGAATGA

Structures

Toxin

• AlphaFold DB: A0A127Q0Q6