Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 1998436..1999029 Replicon chromosome
Accession NZ_CP013234
Organism Collimonas pratensis strain Ter91

Toxin (Protein)


Gene name PumA Uniprot ID A0A127Q2T1
Locus tag CPter91_RS09210 Protein ID WP_061939529.1
Coordinates 1998436..1998726 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A127Q3F4
Locus tag CPter91_RS09215 Protein ID WP_061939531.1
Coordinates 1998736..1999029 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CPter91_RS09200 1993521..1996616 + 3096 WP_061939525.1 efflux RND transporter permease subunit -
CPter91_RS09205 1996647..1998134 + 1488 WP_061939527.1 efflux transporter outer membrane subunit -
CPter91_RS09210 1998436..1998726 + 291 WP_061939529.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CPter91_RS09215 1998736..1999029 + 294 WP_061939531.1 putative addiction module antidote protein Antitoxin
CPter91_RS09220 1999030..1999242 + 213 WP_061939534.1 hypothetical protein -
CPter91_RS09225 1999466..2001373 + 1908 WP_061939536.1 threonine--tRNA ligase -
CPter91_RS09230 2001433..2001957 + 525 WP_081992442.1 translation initiation factor IF-3 -
CPter91_RS09235 2002225..2002422 + 198 WP_061539612.1 50S ribosomal protein L35 -
CPter91_RS09240 2002443..2002802 + 360 WP_061939538.1 50S ribosomal protein L20 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(48-92)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10804.34 Da        Isoelectric Point: 7.8594

>T58166 WP_061939529.1 NZ_CP013234:1998436-1998726 [Collimonas pratensis]
VKTIQTTSVFEHWFASLRDRSVKARIQVRIDRAELGNFGDCKAVGEGVSEMRIHFGCGYRVYFMQRGDEIVILLAGGDKS
AQDKDINTALELARQL

Download         Length: 291 bp

>T58166 NZ_CP013234:1998436-1998726 [Collimonas pratensis]
GTGAAAACTATTCAAACAACGTCTGTATTTGAGCATTGGTTTGCCTCGTTGCGCGACCGCAGCGTCAAAGCGCGGATCCA
AGTGCGCATTGACCGTGCTGAGCTGGGTAATTTTGGCGATTGCAAAGCTGTCGGTGAAGGTGTTTCCGAGATGCGGATTC
ACTTCGGCTGTGGCTACCGGGTCTACTTTATGCAACGTGGCGATGAGATAGTGATATTGCTTGCGGGTGGTGACAAGTCG
GCGCAGGACAAGGACATCAATACCGCGTTGGAATTGGCGCGTCAACTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10261.66 Da        Isoelectric Point: 6.0625

>AT58166 WP_061939531.1 NZ_CP013234:1998736-1999029 [Collimonas pratensis]
MGTIKLRQWDSAEHLQTAADIAAYVDACLEEAGDDPAFIAHALGNVARAHGMSQVARDTGLARESLYKALSGEGNPEFGT
ILKVMKALGLRLHASVA

Download         Length: 294 bp

>AT58166 NZ_CP013234:1998736-1999029 [Collimonas pratensis]
ATGGGAACGATCAAACTGCGTCAGTGGGATTCCGCAGAGCATCTGCAAACCGCGGCCGATATTGCTGCCTATGTCGATGC
CTGCCTTGAAGAAGCGGGTGACGATCCCGCTTTCATCGCACATGCTTTGGGCAACGTTGCGCGCGCGCATGGCATGAGCC
AGGTGGCGCGCGATACCGGGCTGGCGCGCGAAAGCCTGTATAAGGCGCTATCGGGCGAGGGTAATCCCGAGTTCGGAACC
ATTTTGAAAGTCATGAAAGCACTTGGCTTGAGACTGCACGCGAGCGTGGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A127Q2T1

Antitoxin

Source ID Structure
AlphaFold DB A0A127Q3F4

References