Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1305015..1305589 Replicon chromosome
Accession NZ_CP013234
Organism Collimonas pratensis strain Ter91

Toxin (Protein)


Gene name hicA Uniprot ID A0A127Q0Q7
Locus tag CPter91_RS05935 Protein ID WP_061945889.1
Coordinates 1305407..1305589 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A127Q0U1
Locus tag CPter91_RS05930 Protein ID WP_061938220.1
Coordinates 1305015..1305398 (-) Length 128 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CPter91_RS05910 1300209..1301573 + 1365 WP_061938210.1 MFS transporter -
CPter91_RS05915 1301599..1302909 + 1311 WP_061938213.1 homogentisate 1,2-dioxygenase -
CPter91_RS05920 1302923..1304191 + 1269 WP_061938216.1 fumarylacetoacetase -
CPter91_RS05925 1304562..1304980 + 419 Protein_1181 type II toxin-antitoxin system HicB family antitoxin -
CPter91_RS05930 1305015..1305398 - 384 WP_061938220.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
CPter91_RS05935 1305407..1305589 - 183 WP_061945889.1 type II toxin-antitoxin system HicA family toxin Toxin
CPter91_RS05940 1305868..1306551 - 684 WP_061938224.1 DJ-1/PfpI family protein -
CPter91_RS05945 1306649..1307611 + 963 WP_061938227.1 helix-turn-helix domain-containing protein -
CPter91_RS05950 1307677..1308741 - 1065 WP_061938229.1 purine nucleoside permease -
CPter91_RS05955 1308916..1309818 - 903 WP_061938231.1 lipid A hydroxylase LpxO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-121)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6680.76 Da        Isoelectric Point: 10.8513

>T58165 WP_061945889.1 NZ_CP013234:c1305589-1305407 [Collimonas pratensis]
MNSADTVKQLKAAGWRHVSTRGSHHKYRHPVSGKSMIVPYPKKDLPLGTAESILKQAELK

Download         Length: 183 bp

>T58165 NZ_CP013234:c1305589-1305407 [Collimonas pratensis]
ATGAACAGCGCCGACACTGTCAAGCAACTGAAGGCCGCCGGATGGAGGCACGTCTCTACGCGAGGCAGCCACCACAAATA
TCGCCATCCTGTCAGCGGAAAATCAATGATTGTCCCGTATCCGAAAAAGGATCTGCCGCTTGGCACGGCCGAGAGCATCT
TGAAACAGGCCGAACTGAAGTGA

Antitoxin


Download         Length: 128 a.a.        Molecular weight: 14133.10 Da        Isoelectric Point: 5.7298

>AT58165 WP_061938220.1 NZ_CP013234:c1305398-1305015 [Collimonas pratensis]
MLYPLYVWKDKDSAYGASFPDLPGVFTAADELNALPAKAQEAAATMYEGETHIPEATSIEKWKDAADYANGYWMLVNIDR
SRINTKPVRLNISLPENLLREIDAFAKAHQLTRSGFLAQAALKAMAR

Download         Length: 384 bp

>AT58165 NZ_CP013234:c1305398-1305015 [Collimonas pratensis]
ATGCTATATCCGCTTTATGTATGGAAAGACAAAGACAGCGCCTACGGCGCCAGCTTTCCGGATCTTCCCGGCGTGTTTAC
CGCCGCAGACGAATTGAACGCCCTGCCGGCAAAAGCCCAGGAAGCAGCTGCAACCATGTACGAGGGCGAGACACATATTC
CCGAAGCGACATCGATCGAAAAATGGAAAGACGCAGCAGACTATGCCAATGGTTACTGGATGCTGGTGAATATTGACCGT
TCCAGAATCAATACAAAACCTGTGCGGCTCAACATTTCATTACCTGAAAATCTGCTGCGCGAAATTGACGCCTTCGCCAA
AGCCCATCAGCTGACGCGTTCCGGCTTCCTGGCTCAGGCTGCATTGAAAGCGATGGCTCGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A127Q0Q7

Antitoxin

Source ID Structure
AlphaFold DB A0A127Q0U1

References