Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 5593293..5594948 Replicon chromosome
Accession NZ_CP013232
Organism Collimonas fungivorans strain Ter6

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag CFter6_RS24640 Protein ID WP_061542130.1
Coordinates 5593608..5594948 (+) Length 447 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A127PJJ1
Locus tag CFter6_RS24635 Protein ID WP_061542129.1
Coordinates 5593293..5593604 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFter6_RS24605 5588585..5589103 + 519 WP_061542123.1 hypothetical protein -
CFter6_RS24610 5589100..5590899 + 1800 WP_061542124.1 hypothetical protein -
CFter6_RS24615 5591082..5591399 - 318 WP_061542125.1 hypothetical protein -
CFter6_RS24620 5591691..5592128 + 438 WP_061542126.1 prepilin-type N-terminal cleavage/methylation domain-containing protein -
CFter6_RS24625 5592263..5592469 + 207 WP_061542127.1 hypothetical protein -
CFter6_RS24630 5592698..5593150 - 453 WP_061542128.1 hypothetical protein -
CFter6_RS24635 5593293..5593604 + 312 WP_061542129.1 helix-turn-helix domain-containing protein Antitoxin
CFter6_RS24640 5593608..5594948 + 1341 WP_061542130.1 type II toxin-antitoxin system HipA family toxin Toxin
CFter6_RS24645 5595108..5596505 - 1398 WP_061542131.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
CFter6_RS24650 5596622..5598304 - 1683 WP_061542132.1 membrane protein insertase YidC -
CFter6_RS25320 5598324..5598608 - 285 WP_014008419.1 membrane protein insertion efficiency factor YidD -
CFter6_RS25325 5598718..5599188 - 471 WP_082814977.1 ribonuclease P protein component -
CFter6_RS25330 5599148..5599282 - 135 WP_061535510.1 50S ribosomal protein L34 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(11-110)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-66)


Sequences

Toxin        


Download         Length: 447 a.a.        Molecular weight: 49085.82 Da        Isoelectric Point: 6.2353

>T58161 WP_061542130.1 NZ_CP013232:5593608-5594948 [Collimonas fungivorans]
MGRRSHTQRLVIWLNGIAVGQWTAAPGRPSFNYFDAWLEDEQGRPLSLSLPFTPNNEPYRGELVSNYFDNMLPDSDPIRR
RLAQRFQTGGIEPFQLLAAIGRDCVGAVQLLPAGEEPVGLFSIAGQPLDESGIARLLRRSTSAAPLSRDDEENDLRLSIA
GAQEKTALLRHQGQWLLPAASTPTSHILKLPLGLVGHMQADMRTSVENEWLCSKIVEAFGLPVAFCDIACYEDQKALIVE
RFDRRLSADASWIVRLPQEDFFQATGSSALHKYQADGGPGIADIMDVLLGSEQANIDRRNFFKAQLLFWLLAATDGHAKN
FSIAHHPGGRFRATPLYDILSAHPILGAGNNQLAPQKARLAMAVRGSANYYHLEQIQRRHWDKMARQVGLGAHAAEEIIE
ELIAASGGVAEAVSRQLPADFPGDVAESILTGMLRQCEKLQAMQAL

Download         Length: 1341 bp

>T58161 NZ_CP013232:5593608-5594948 [Collimonas fungivorans]
ATGGGACGACGCTCGCACACCCAACGCCTCGTCATTTGGCTTAACGGTATTGCTGTTGGCCAATGGACTGCTGCACCCGG
CCGCCCCTCGTTCAACTACTTCGACGCATGGCTTGAGGATGAGCAAGGTCGTCCGCTGTCCCTGTCCTTGCCGTTTACGC
CGAACAATGAGCCATACCGAGGCGAACTGGTATCGAATTATTTCGACAATATGCTGCCGGACAGCGATCCTATACGCCGG
CGCCTGGCGCAGCGTTTTCAAACTGGCGGTATTGAGCCATTTCAGTTGCTGGCCGCGATCGGGCGCGACTGCGTTGGCGC
GGTGCAGCTGCTGCCGGCAGGCGAAGAGCCGGTTGGCCTGTTTAGCATAGCCGGCCAGCCGCTCGACGAAAGCGGCATCG
CCCGCCTGCTGCGCAGGAGCACCTCGGCAGCGCCGCTGAGCCGGGATGATGAAGAGAACGATTTGCGCCTCTCCATTGCA
GGCGCACAAGAAAAAACGGCCTTGTTGAGACATCAAGGACAATGGCTGCTTCCCGCCGCCAGTACTCCTACCAGCCATAT
CCTCAAGTTGCCGCTTGGTCTTGTCGGCCACATGCAGGCGGACATGCGTACTTCGGTCGAGAATGAATGGCTGTGCTCGA
AGATCGTCGAAGCCTTCGGCTTGCCCGTCGCGTTTTGCGACATCGCATGCTACGAAGACCAGAAGGCGTTGATTGTAGAA
CGCTTCGACCGCAGGCTTTCGGCAGACGCCAGCTGGATCGTGCGCTTGCCGCAGGAGGACTTTTTCCAGGCGACAGGTTC
CTCGGCGCTGCACAAATACCAGGCTGACGGCGGTCCCGGCATCGCCGACATCATGGATGTGCTGCTAGGATCAGAACAGG
CCAATATTGACCGGCGCAATTTCTTCAAGGCCCAGCTGCTGTTCTGGCTGTTGGCCGCTACCGATGGCCACGCCAAGAAC
TTCAGCATTGCGCACCATCCCGGCGGCCGGTTTCGCGCGACGCCGCTATACGATATCTTGTCGGCCCATCCCATCCTTGG
CGCCGGAAATAACCAGCTGGCGCCGCAAAAAGCCAGGCTGGCGATGGCGGTACGGGGCAGCGCCAACTACTACCACCTGG
AGCAGATTCAACGACGCCATTGGGACAAGATGGCCCGGCAGGTTGGCCTTGGCGCTCATGCCGCCGAAGAAATCATCGAG
GAATTAATTGCCGCGTCAGGGGGAGTCGCCGAAGCCGTGTCACGTCAGTTGCCCGCCGATTTTCCGGGCGACGTAGCAGA
ATCCATCTTGACAGGCATGCTGCGCCAGTGCGAAAAGCTGCAGGCAATGCAAGCTCTCTGA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11459.25 Da        Isoelectric Point: 10.1346

>AT58161 WP_061542129.1 NZ_CP013232:5593293-5593604 [Collimonas fungivorans]
MSYPIKTLGQLRPILQGFRKEAGFTQAAMASQLGITQQSYAQIEANPASTSVERLYKIMRLLNVELVLAHEPPQAGDATQ
AEQPKKAQTLRKIVPPSEKKEPW

Download         Length: 312 bp

>AT58161 NZ_CP013232:5593293-5593604 [Collimonas fungivorans]
ATGAGCTACCCGATCAAAACACTTGGTCAATTACGTCCCATCCTGCAAGGATTCCGCAAGGAAGCCGGATTTACGCAAGC
TGCAATGGCGAGCCAGCTTGGCATTACGCAGCAGAGCTATGCCCAGATCGAGGCCAATCCTGCTTCGACCAGCGTGGAGC
GCTTATACAAGATCATGCGTCTCCTGAATGTCGAACTGGTATTGGCCCATGAGCCGCCGCAGGCAGGCGACGCCACCCAG
GCCGAGCAACCGAAGAAAGCGCAAACGCTTCGTAAAATTGTTCCACCGTCAGAAAAAAAAGAGCCGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A127PJJ1

References