Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4211318..4211891 Replicon chromosome
Accession NZ_CP013232
Organism Collimonas fungivorans strain Ter6

Toxin (Protein)


Gene name hicA Uniprot ID A0A127PFU5
Locus tag CFter6_RS18305 Protein ID WP_061541132.1
Coordinates 4211318..4211500 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A127PG40
Locus tag CFter6_RS18310 Protein ID WP_061541133.1
Coordinates 4211508..4211891 (+) Length 128 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFter6_RS18280 4206572..4207576 - 1005 WP_061541130.1 sodium:calcium antiporter -
CFter6_RS18285 4208040..4208942 + 903 WP_014007191.1 lipid A hydroxylase LpxO -
CFter6_RS18290 4209088..4210152 + 1065 WP_061541131.1 purine nucleoside permease -
CFter6_RS18295 4210235..4210651 - 417 WP_061542457.1 type II toxin-antitoxin system HicB family antitoxin -
CFter6_RS18300 4210755..4210931 - 177 WP_061542458.1 type II toxin-antitoxin system HicA family toxin -
CFter6_RS18305 4211318..4211500 + 183 WP_061541132.1 type II toxin-antitoxin system HicA family toxin Toxin
CFter6_RS18310 4211508..4211891 + 384 WP_061541133.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
CFter6_RS18315 4212125..4212616 + 492 WP_061541134.1 type VI secretion system tube protein Hcp -
CFter6_RS18320 4212681..4213949 - 1269 WP_061541135.1 fumarylacetoacetase -
CFter6_RS18325 4213964..4215268 - 1305 WP_061541136.1 homogentisate 1,2-dioxygenase -
CFter6_RS18330 4215294..4216649 - 1356 WP_061541137.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4208040..4221012 12972


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-121)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6548.67 Da        Isoelectric Point: 11.1039

>T58155 WP_061541132.1 NZ_CP013232:4211318-4211500 [Collimonas fungivorans]
MSSADIIKQLKAAGWKHVSTRGSHHKYRHPVTGKSVIVPHPKKDLALGTTESILKHAGLK

Download         Length: 183 bp

>T58155 NZ_CP013232:4211318-4211500 [Collimonas fungivorans]
ATGAGCAGCGCAGACATTATCAAACAACTGAAAGCAGCCGGCTGGAAGCATGTTTCCACTCGTGGCAGCCATCACAAATA
CCGCCATCCCGTTACCGGCAAATCGGTAATTGTTCCGCATCCGAAGAAAGACCTGGCGCTGGGAACAACCGAGAGCATCC
TGAAACACGCTGGACTGAAATGA

Antitoxin


Download         Length: 128 a.a.        Molecular weight: 14136.16 Da        Isoelectric Point: 5.1663

>AT58155 WP_061541133.1 NZ_CP013232:4211508-4211891 [Collimonas fungivorans]
MLYPLYVWKDKSSAYGARFPDLPGVFTAADELNDLPAMAQEAAKTMYEGEVHIPEASSIEKWKDAADYAGGFWMLVDIDR
SKINTKPVRLNISLPENLLRDIDAFAKSHQLTRSGFLAQAALKAMAQ

Download         Length: 384 bp

>AT58155 NZ_CP013232:4211508-4211891 [Collimonas fungivorans]
ATGTTATATCCGCTCTATGTATGGAAGGACAAAAGCAGCGCGTATGGCGCCCGCTTCCCGGATCTGCCCGGCGTATTTAC
TGCCGCCGACGAATTGAATGATCTTCCGGCCATGGCACAGGAAGCTGCGAAAACCATGTACGAGGGGGAAGTGCATATTC
CCGAGGCGTCATCCATCGAGAAATGGAAAGATGCAGCGGACTACGCCGGCGGTTTCTGGATGCTGGTCGATATCGATCGT
TCGAAAATCAATACCAAACCCGTCCGGCTAAACATCTCGTTGCCGGAAAACCTGTTGCGCGACATCGACGCTTTCGCCAA
GTCGCATCAGCTGACCCGATCCGGATTCCTGGCCCAGGCTGCGCTGAAAGCGATGGCGCAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A127PFU5

Antitoxin

Source ID Structure
AlphaFold DB A0A127PG40

References