Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 4210235..4210931 Replicon chromosome
Accession NZ_CP013232
Organism Collimonas fungivorans strain Ter6

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag CFter6_RS18300 Protein ID WP_061542458.1
Coordinates 4210755..4210931 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag CFter6_RS18295 Protein ID WP_061542457.1
Coordinates 4210235..4210651 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFter6_RS18270 4205824..4206144 + 321 WP_061541128.1 ribbon-helix-helix domain-containing protein -
CFter6_RS18275 4206148..4206468 - 321 WP_061541129.1 quaternary ammonium compound efflux SMR transporter SugE -
CFter6_RS18280 4206572..4207576 - 1005 WP_061541130.1 sodium:calcium antiporter -
CFter6_RS18285 4208040..4208942 + 903 WP_014007191.1 lipid A hydroxylase LpxO -
CFter6_RS18290 4209088..4210152 + 1065 WP_061541131.1 purine nucleoside permease -
CFter6_RS18295 4210235..4210651 - 417 WP_061542457.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
CFter6_RS18300 4210755..4210931 - 177 WP_061542458.1 type II toxin-antitoxin system HicA family toxin Toxin
CFter6_RS18305 4211318..4211500 + 183 WP_061541132.1 type II toxin-antitoxin system HicA family toxin -
CFter6_RS18310 4211508..4211891 + 384 WP_061541133.1 type II toxin-antitoxin system HicB family antitoxin -
CFter6_RS18315 4212125..4212616 + 492 WP_061541134.1 type VI secretion system tube protein Hcp -
CFter6_RS18320 4212681..4213949 - 1269 WP_061541135.1 fumarylacetoacetase -
CFter6_RS18325 4213964..4215268 - 1305 WP_061541136.1 homogentisate 1,2-dioxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4208040..4221012 12972


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-57)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6694.79 Da        Isoelectric Point: 10.8973

>T58154 WP_061542458.1 NZ_CP013232:c4210931-4210755 [Collimonas fungivorans]
VKQSEFVKWLTQQGATFKDGSKHIKVYLHGKQSHLPRHQNKELKTGLVEGVKKQLNLK

Download         Length: 177 bp

>T58154 NZ_CP013232:c4210931-4210755 [Collimonas fungivorans]
GTGAAGCAAAGTGAATTTGTAAAGTGGCTGACGCAACAGGGAGCGACTTTCAAGGACGGATCGAAACACATAAAAGTCTA
TTTGCATGGCAAACAATCCCACCTGCCAAGACACCAGAACAAGGAGCTCAAGACAGGGCTTGTTGAAGGCGTGAAAAAGC
AGCTCAATTTAAAATGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15373.81 Da        Isoelectric Point: 5.2191

>AT58154 WP_061542457.1 NZ_CP013232:c4210651-4210235 [Collimonas fungivorans]
MKYPATLTPDPDGGFVVTFRDIPEAISQGDDKFEALDMAADVLLSAMDFYFEDKRKVPLPSKAKRGEILVDIPLSVTAKV
LLLNEMLAQHIRPTDLALRMDTTKQEVNRLIDLHHTTKIDRISDAMSALGKHIELSVA

Download         Length: 417 bp

>AT58154 NZ_CP013232:c4210651-4210235 [Collimonas fungivorans]
ATGAAATACCCAGCAACACTCACGCCGGATCCTGATGGTGGTTTTGTCGTTACTTTCCGCGACATACCTGAGGCCATTAG
TCAAGGCGATGATAAATTCGAAGCGCTCGACATGGCTGCCGATGTATTACTGAGCGCCATGGATTTTTATTTCGAGGACA
AGCGCAAGGTGCCATTGCCATCCAAGGCAAAAAGAGGGGAGATTTTGGTAGATATTCCGCTGAGTGTTACAGCCAAGGTT
CTGCTGCTCAATGAAATGCTGGCGCAACATATCCGGCCGACTGATCTGGCTCTTCGCATGGATACAACGAAACAGGAAGT
AAACCGTCTGATTGATCTGCATCACACAACCAAGATCGACAGAATTTCCGACGCAATGAGTGCGCTTGGCAAGCACATTG
AATTGAGCGTGGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References