Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 2054256..2054849 Replicon chromosome
Accession NZ_CP013232
Organism Collimonas fungivorans strain Ter6

Toxin (Protein)


Gene name relE Uniprot ID A0A127PAX4
Locus tag CFter6_RS08795 Protein ID WP_061542274.1
Coordinates 2054256..2054546 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A127P9U8
Locus tag CFter6_RS08800 Protein ID WP_061539610.1
Coordinates 2054556..2054849 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFter6_RS08785 2049436..2052531 + 3096 WP_061539609.1 efflux RND transporter permease subunit -
CFter6_RS08790 2052564..2054093 + 1530 WP_082814670.1 efflux transporter outer membrane subunit -
CFter6_RS08795 2054256..2054546 + 291 WP_061542274.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CFter6_RS08800 2054556..2054849 + 294 WP_061539610.1 putative addiction module antidote protein Antitoxin
CFter6_RS08805 2055278..2057184 + 1907 Protein_1789 threonine--tRNA ligase -
CFter6_RS08810 2057245..2057769 + 525 WP_082814671.1 translation initiation factor IF-3 -
CFter6_RS08815 2057962..2058159 + 198 WP_061539612.1 50S ribosomal protein L35 -
CFter6_RS08820 2058180..2058539 + 360 WP_014005489.1 50S ribosomal protein L20 -
CFter6_RS08825 2058756..2059772 + 1017 WP_061539613.1 phenylalanine--tRNA ligase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(49-91)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10734.53 Da        Isoelectric Point: 10.0588

>T58152 WP_061542274.1 NZ_CP013232:2054256-2054546 [Collimonas fungivorans]
VKIIQTTPVFDNWFASLRDRSVKVRIQMRIDRAEFGNFGDCAPVGEGVSEMLVHFGCGYRVYFVQRGDEMVVLLAGGGKP
TQSKDIKTALKLARKL

Download         Length: 291 bp

>T58152 NZ_CP013232:2054256-2054546 [Collimonas fungivorans]
GTGAAAATTATTCAAACAACGCCGGTATTTGATAATTGGTTTGCCTCGTTGCGCGATCGCAGCGTCAAAGTGCGCATCCA
GATGCGCATTGATCGTGCCGAGTTCGGTAATTTTGGCGATTGCGCACCGGTCGGAGAGGGTGTCTCCGAGATGCTGGTTC
ATTTTGGCTGCGGCTACCGAGTATATTTTGTGCAGCGTGGCGATGAAATGGTGGTATTGCTTGCCGGTGGCGGGAAGCCA
ACACAAAGCAAGGACATCAAGACGGCGTTGAAACTGGCGCGGAAACTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10385.89 Da        Isoelectric Point: 7.2771

>AT58152 WP_061539610.1 NZ_CP013232:2054556-2054849 [Collimonas fungivorans]
MGTIKLRQWDSAEHLQTSADIVAYFDACLKEAGDDPAFIAHALGNIARARGMSQIARDTGLARESLYKALSGEGNPEFGT
ILKVMKALGLRLHATAA

Download         Length: 294 bp

>AT58152 NZ_CP013232:2054556-2054849 [Collimonas fungivorans]
ATGGGAACGATCAAATTGCGTCAGTGGGACTCTGCCGAGCATCTGCAAACCAGCGCCGATATCGTTGCCTATTTTGATGC
ATGTCTTAAAGAGGCGGGCGATGATCCTGCCTTCATCGCGCATGCCCTGGGCAATATTGCGCGCGCACGCGGCATGAGCC
AGATAGCGCGGGATACCGGGCTGGCGCGCGAAAGCCTGTATAAGGCACTGTCTGGCGAGGGTAATCCCGAGTTCGGAACC
ATTCTGAAAGTCATGAAAGCGCTTGGATTGAGGCTGCACGCGACTGCGGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A127PAX4

Antitoxin

Source ID Structure
AlphaFold DB A0A127P9U8

References