Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 5396317..5396842 Replicon chromosome
Accession NZ_CP013219
Organism Streptomyces hygroscopicus subsp. limoneus strain KCTC 1717

Toxin (Protein)


Gene name relE Uniprot ID A0A0S2P548
Locus tag SHL15_RS23775 Protein ID WP_058081753.1
Coordinates 5396317..5396580 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0S2P5Q8
Locus tag SHL15_RS23780 Protein ID WP_058081754.1
Coordinates 5396573..5396842 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SHL15_RS23755 5392008..5393096 + 1089 WP_014674714.1 redox-regulated ATPase YchF -
SHL15_RS23760 5393207..5393788 - 582 WP_058081750.1 Uma2 family endonuclease -
SHL15_RS23765 5393872..5395497 - 1626 WP_079088078.1 type I restriction-modification system subunit M/S -
SHL15_RS46900 5395881..5396257 + 377 Protein_4777 helix-turn-helix domain-containing protein -
SHL15_RS23775 5396317..5396580 - 264 WP_058081753.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SHL15_RS23780 5396573..5396842 - 270 WP_058081754.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SHL15_RS23785 5397088..5397552 - 465 WP_058081755.1 GNAT family N-acetyltransferase -
SHL15_RS23790 5397699..5398916 - 1218 WP_058083638.1 IS110 family transposase -
SHL15_RS23795 5399303..5400433 - 1131 WP_058081756.1 DNA polymerase III subunit beta -
SHL15_RS23800 5400517..5401020 - 504 WP_014674734.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 5397699..5398976 1277


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-60)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10013.42 Da        Isoelectric Point: 7.2015

>T58132 WP_058081753.1 NZ_CP013219:c5396580-5396317 [Streptomyces hygroscopicus subsp. limoneus]
VSEYRTVFRPEAQAELRKIPRDMALRILAALTELESDPLGFNSTALVSQPERRRLRVGDYRIVYTIDNGELVVWVVHVGH
RSTVYDT

Download         Length: 264 bp

>T58132 NZ_CP013219:c5396580-5396317 [Streptomyces hygroscopicus subsp. limoneus]
GTGAGTGAATACCGAACCGTCTTCCGGCCGGAGGCACAGGCTGAGCTCCGGAAGATCCCTCGCGACATGGCCCTACGCAT
CCTGGCCGCACTGACCGAGCTGGAGAGCGACCCCCTCGGCTTCAACAGCACCGCGCTCGTGTCACAGCCAGAACGCCGTC
GACTGCGGGTCGGCGACTACCGGATCGTCTACACGATCGACAACGGAGAGCTCGTAGTGTGGGTCGTCCACGTCGGGCAT
CGCTCCACCGTTTACGACACCTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10244.70 Da        Isoelectric Point: 4.7473

>AT58132 WP_058081754.1 NZ_CP013219:c5396842-5396573 [Streptomyces hygroscopicus subsp. limoneus]
MTQPLPIESIRDVRAHLAEVVERADRDDVPTVITRRGKQVAAVVSIEVLRKYQEWEEREINRVIDERMANPAPGIPIEDI
MRETLARGE

Download         Length: 270 bp

>AT58132 NZ_CP013219:c5396842-5396573 [Streptomyces hygroscopicus subsp. limoneus]
ATGACGCAGCCGCTCCCCATAGAGTCCATCCGCGACGTACGTGCGCACCTGGCCGAGGTCGTGGAGCGCGCCGATCGGGA
TGACGTGCCCACCGTGATCACCCGGCGGGGCAAGCAAGTCGCCGCCGTCGTCTCCATCGAGGTGCTGCGCAAGTACCAGG
AGTGGGAAGAGCGCGAGATCAACCGGGTCATCGACGAACGCATGGCCAACCCGGCACCCGGCATCCCGATCGAGGACATC
ATGAGGGAGACGCTGGCGCGCGGTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0S2P548

Antitoxin

Source ID Structure
AlphaFold DB A0A0S2P5Q8

References