Detailed information of TA system TA058124

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /HTH_XRE(antitoxin)
• Location: 1584313..1585116
• Replicon: chromosome
• Accession: NZ_CP013218
• Organism: Staphylococcus aureus strain LA-MRSA ST398 isolate E154

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A2I7Y5B3
• Locus tag: AS852_RS07950
• Protein ID: WP_000525004.1
• Coordinates: 1584655..1585116 (+)
• Length: 154 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: AS852_RS07945
• Protein ID: WP_071938164.1
• Coordinates: 1584313..1584642 (+)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AS852_RS07880	1580294..1580656	-	363	WP_071938163.1	hypothetical protein	-
AS852_RS07885	1580671..1580994	-	324	WP_000174994.1	hypothetical protein	-
AS852_RS07890	1581073..1581234	-	162	WP_001285955.1	DUF1270 family protein	-
AS852_RS07895	1581247..1581510	-	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
AS852_RS07900	1581535..1581750	-	216	WP_001097552.1	hypothetical protein	-
AS852_RS07905	1581805..1582170	+	366	WP_001128433.1	hypothetical protein	-
AS852_RS07910	1582139..1582384	-	246	WP_001025401.1	DUF2829 domain-containing protein	-
AS852_RS07915	1582451..1582831	+	381	WP_000773059.1	DUF2513 domain-containing protein	-
AS852_RS07920	1582818..1583015	-	198	WP_001148860.1	hypothetical protein	-
AS852_RS07925	1583085..1583297	+	213	WP_000362644.1	hypothetical protein	-
AS852_RS15285	1583338..1583487	-	150	WP_000771849.1	hypothetical protein	-
AS852_RS07930	1583543..1583752	+	210	WP_000642492.1	hypothetical protein	-
AS852_RS07935	1583742..1583885	-	144	WP_000939498.1	hypothetical protein	-
AS852_RS07940	1583901..1584149	-	249	WP_000272860.1	helix-turn-helix domain-containing protein	-
AS852_RS07945	1584313..1584642	+	330	WP_071938164.1	helix-turn-helix domain-containing protein	Antitoxin
AS852_RS07950	1584655..1585116	+	462	WP_000525004.1	hypothetical protein	Toxin
AS852_RS07955	1585134..1585718	+	585	WP_000825948.1	hypothetical protein	-
AS852_RS07960	1585948..1586094	+	147	WP_078099401.1	hypothetical protein	-
AS852_RS07965	1586091..1586705	-	615	WP_000191458.1	hypothetical protein	-
AS852_RS07970	1586831..1588036	+	1206	WP_000264747.1	site-specific integrase	-
AS852_RS07975	1588079..1590105	-	2027	Protein_1480	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1540903..1600791	59888

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (8-65)

Sequences

Toxin

Protein

• Length: 154 a.a.
• Molecular weight: 18074.46 Da
• Isoelectric Point: 4.6915

>T58124 WP_000525004.1 NZ_CP013218:1584655-1585116 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Nucleotide

• Length: 462 bp

>T58124 NZ_CP013218:1584655-1585116 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTGCTTCCAGATAATTTGGA
TGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGCTTATCAGATAGAGAAAAGGCAGGAATTCTCTTTGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGG
CGACACGGCTTTATCTCAGCAGTCCCGTTACGCGAAATTGTGGAAGCTTACAATTATGGTGTACGTAACTTGTATGAGTT
GTCTGAGTATCTGCAATTGAGTGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGGACTC
ACTACGGCGAATACTCAATTACATTTGAGCCATTGAGAGTTTTTAAATATAAAGAAATATAA

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 12657.28 Da
• Isoelectric Point: 7.2034

>AT58124 WP_071938164.1 NZ_CP013218:1584313-1584642 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQPENDDEVQH
RAAHLEGELTDDEWQRVLDYADYIRSKRK

Nucleotide

• Length: 330 bp

>AT58124 NZ_CP013218:1584313-1584642 [Staphylococcus aureus]
ATGAGAACTTCAGCGGAAATAGGTAAATTAATCAAACAACTACGAAAAGAAAATAATGTGAATTTAACTGATTTTGCAAC
TAAGATAGGTGTCAATAAATCTACCTTATCCCGATACGAAAACGGTAGCAGAAAAATACCTATGGAGGATATAGCTGAAA
TTGCCAATGCATTGAAAGTTACCCCAGAATATTTACTATTAAAAAATAGACAACCAGAAAACGATGATGAAGTACAACAT
CGTGCAGCTCACCTTGAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGCAA
ACGTAAGTAA

Structures

Toxin

• AlphaFold DB: A0A2I7Y5B3