Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 859177..859653 Replicon chromosome
Accession NZ_CP013218
Organism Staphylococcus aureus strain LA-MRSA ST398 isolate E154

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag AS852_RS04270 Protein ID WP_000052076.1
Coordinates 859177..859365 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag AS852_RS04275 Protein ID WP_001059690.1
Coordinates 859393..859653 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AS852_RS04240 855206..855688 + 483 WP_000824489.1 hypothetical protein -
AS852_RS04245 856029..856715 + 687 WP_001574556.1 thermonuclease family protein -
AS852_RS04250 857072..857272 + 201 WP_001059082.1 cold-shock protein -
AS852_RS04255 857769..857987 - 219 WP_000005881.1 hypothetical protein -
AS852_RS04260 858048..858332 - 285 WP_001004403.1 hypothetical protein -
AS852_RS04265 858420..858989 - 570 WP_001106655.1 hypothetical protein -
AS852_RS04270 859177..859365 - 189 WP_000052076.1 hypothetical protein Toxin
AS852_RS04275 859393..859653 - 261 WP_001059690.1 hypothetical protein Antitoxin
AS852_RS04280 859995..860198 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
AS852_RS04285 860195..860431 - 237 WP_000368687.1 hypothetical protein -
AS852_RS04290 860656..861237 + 582 WP_001140696.1 phosphoglycerate mutase family protein -
AS852_RS04295 861310..861927 - 618 WP_000255562.1 LysE/ArgO family amino acid transporter -
AS852_RS04300 862076..862570 - 495 WP_000569881.1 GNAT family N-acetyltransferase -
AS852_RS04305 862969..863391 - 423 WP_000974452.1 organic hydroperoxide resistance protein -
AS852_RS04310 863539..864255 + 717 WP_000150026.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(10-82)

Antitoxin

Antitoxin MqsA/HigA-2

(1-131)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T58120 WP_000052076.1 NZ_CP013218:c859365-859177 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T58120 NZ_CP013218:c859365-859177 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT58120 WP_001059690.1 NZ_CP013218:c859653-859393 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT58120 NZ_CP013218:c859653-859393 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References