Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemK-mazE/MazF(toxin)
Location 1115060..1115668 Replicon chromosome
Accession NZ_CP013203
Organism Paenibacillus sp. IHB B 3084

Toxin (Protein)


Gene name pemK Uniprot ID H6CFY1
Locus tag ASL14_RS05245 Protein ID WP_007429335.1
Coordinates 1115060..1115410 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag ASL14_RS05250 Protein ID WP_170970806.1
Coordinates 1115417..1115668 (-) Length 84 a.a.

Genomic Context

ASL14_RS05215ASL14_RS05235ASL14_RS05230ASL14_RS05240ASL14_RS05245ASL14_RS05250ASL14_RS05255ASL14_RS05260ASL14_RS05265
Location: 1110568..1111440 (873 bp)
Type: Others
Protein ID: WP_134910711.1
Location: 1112419..1112553 (135 bp)
Type: Others
Protein ID: WP_007429337.1
Location: 1111746..1112258 (513 bp)
Type: Others
Protein ID: WP_134910712.1
Location: 1112657..1114879 (2223 bp)
Type: Others
Protein ID: WP_189338230.1
Location: 1115060..1115410 (351 bp)
Type: Toxin
Protein ID: WP_007429335.1
Location: 1115417..1115668 (252 bp)
Type: Antitoxin
Protein ID: WP_170970806.1
Location: 1115993..1117189 (1197 bp)
Type: Others
Protein ID: WP_134910714.1
Location: 1117452..1118774 (1323 bp)
Type: Others
Protein ID: WP_134910715.1
Location: 1119175..1120047 (873 bp)
Type: Others
Protein ID: WP_134914403.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASL14_RS052151110568..1111440+873WP_134910711.1Cof-type HAD-IIB family hydrolase-
ASL14_RS052301111746..1112258-513WP_134910712.1SprT family protein-
ASL14_RS052351112419..1112553+135WP_007429337.1cortex morphogenetic protein CmpA-
ASL14_RS052401112657..1114879-2223WP_189338230.1RNA-binding transcriptional accessory protein-
ASL14_RS052451115060..1115410-351WP_007429335.1type II toxin-antitoxin system PemK/MazF family toxinToxin
ASL14_RS052501115417..1115668-252WP_170970806.1ribbon-helix-helix protein, CopG familyAntitoxin
ASL14_RS052551115993..1117189-1197WP_134910714.1alanine racemase-
ASL14_RS052601117452..1118774-1323WP_134910715.1outer membrane lipoprotein carrier protein LolA-
ASL14_RS052651119175..1120047-873WP_134914403.1class II fructose-1,6-bisphosphate aldolase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-36)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12822.77 Da        Isoelectric Point: 5.6195

>T58117 WP_007429335.1 NZ_CP013203:c1115410-1115060 [Paenibacillus sp. IHB B 3084]
MIVKRGDVFFADLSPVVGSEQGGVRPVLIIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAATHGFDRDSVVLLEQI
RTIDKQRLTDKITHLDEETMRKVSDSLQISLGLIDF

Download         Length: 351 bp

>T58117 NZ_CP013203:c1115410-1115060 [Paenibacillus sp. IHB B 3084]
TTGATCGTAAAGCGCGGCGACGTTTTTTTTGCAGACCTTTCACCCGTAGTCGGTTCCGAGCAAGGTGGCGTCAGACCTGT
GCTGATCATTCAAAATGATATCGGCAACCGGTTCAGTCCCACCGTGATCGTGGCAGCCATCACCGCCCAGATTCAGAAGG
CGAAGCTGCCCACACACGTGGAAATCGACGCGGCGACGCATGGCTTTGATCGCGATTCTGTCGTTCTTCTGGAGCAAATT
CGGACGATCGACAAGCAAAGGCTTACCGACAAAATCACCCATTTGGATGAAGAAACCATGCGCAAAGTGAGCGATTCGCT
ACAAATCAGTCTCGGTTTGATTGATTTTTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9465.86 Da        Isoelectric Point: 6.4671

>AT58117 WP_170970806.1 NZ_CP013203:c1115668-1115417 [Paenibacillus sp. IHB B 3084]
MISLPDHLLQEVDGIVAMENSNRSEFIRQAMKLYVGERKKRYIREAMQRGYMEMAKINLTMASEAFHAEEDANSTLGRTV
SGV

Download         Length: 252 bp

>AT58117 NZ_CP013203:c1115668-1115417 [Paenibacillus sp. IHB B 3084]
ATGATCAGTTTGCCGGATCATCTCTTGCAGGAAGTGGACGGGATCGTAGCTATGGAAAATTCCAACCGCAGTGAATTTAT
CAGGCAGGCCATGAAGCTGTATGTAGGCGAACGAAAAAAACGTTACATTCGTGAAGCTATGCAGCGTGGTTATATGGAGA
TGGCTAAAATTAACTTGACCATGGCCTCCGAAGCCTTTCATGCGGAGGAAGATGCAAACAGCACCTTGGGCCGTACAGTT
AGCGGGGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBH6CFY1

Antitoxin

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Source
ID
Structure
No matching records found

References